| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4771–4772. doi: 10.1073/iti.1207104.PMCID: PMC1829210 Commentaries Unlocking and opening a DNA gate James C. Wang Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4773–4774. Published online 2007 March 15. doi: 10.1073/pnas.0701070104.PMCID: PMC1829211 DNA barcoding and the renaissance of taxonomy Scott E. Miller Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4775–4776. Published online 2007 March 15. doi: 10.1073/pnas.0700466104.PMCID: PMC1829212 New tools to build synthetic hormonal pathways Bruce R. Conklin Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4777–4778. Published online 2007 March 12. doi: 10.1073/pnas.0700913104.PMCID: PMC1829213 Profile Profile of Monica G. Turner Nick Zagorski Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4779–4781. Published online 2007 March 12. doi: 10.1073/pnas.0701264104.PMCID: PMC1829214 Physical Sciences Applied Mathematics The role of cells refractory to productive infection in acute hepatitis B viral dynamics Stanca M. Ciupe, Ruy M. Ribeiro, Patrick W. Nelson, Geoffrey Dusheiko, and Alan S. Perelson Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5050–5055. Published online 2007 March 14. doi: 10.1073/pnas.0603626104.PMCID: PMC1829262 Applied Physical Sciences Pattern regulation in the stripe of zebrafish suggests an underlying dynamic and autonomous mechanism Motoomi Yamaguchi, Eiichi Yoshimoto, and Shigeru Kondo Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4790–4793. Published online 2007 March 12. doi: 10.1073/pnas.0607790104.PMCID: PMC1820822 Chemistry Electronic energy delocalization and dissipation in single- and double-stranded DNA Ivan Buchvarov, Qiang Wang, Milen Raytchev, Anton Trifonov, and Torsten Fiebig Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4794–4797. Published online 2007 March 12. doi: 10.1073/pnas.0606757104.PMCID: PMC1829217 Functional, fractal nonlinear response with application to rate processes with memory, allometry, and population genetics Marcel O. Vlad, Federico Morán, Vlad T. Popa, Stefan E. Szedlacsek, and John Ross Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4798–4803. Published online 2007 March 14. doi: 10.1073/pnas.0700397104.PMCID: PMC1829218 Bound anionic states of adenine Maciej Harańczyk, Maciej Gutowski, Xiang Li, and Kit H. Bowen Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4804–4807. Published online 2007 March 12. doi: 10.1073/pnas.0609982104.PMCID: PMC1829219 Synthesis and evaluation of transthyretin amyloidosis inhibitors containing carborane pharmacophores Richard L. Julius, Omar K. Farha, Janet Chiang, L. Jeanne Perry, and M. Frederick Hawthorne Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4808–4813. Published online 2007 March 13. doi: 10.1073/pnas.0700316104.PMCID: PMC1829220 Convergent chemical synthesis and high-resolution x-ray structure of human lysozyme Thomas Durek, Vladimir Yu. Torbeev, and Stephen B. H. Kent Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4846–4851. Published online 2007 March 8. doi: 10.1073/pnas.0610630104.PMCID: PMC1829227 Environmental Sciences The importance of the Montreal Protocol in protecting climate Guus J. M. Velders, Stephen O. Andersen, John S. Daniel, David W. Fahey, and Mack McFarland Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4814–4819. Published online 2007 March 8. doi: 10.1073/pnas.0610328104.PMCID: PMC1817831 Large seasonal swings in leaf area of Amazon rainforests Ranga B. Myneni, Wenze Yang, Ramakrishna R. Nemani, Alfredo R. Huete, Robert E. Dickinson, Yuri Knyazikhin, Kamel Didan, Rong Fu, Robinson I. Negrón Juárez, Sasan S. Saatchi, Hirofumi Hashimoto, Kazuhito Ichii, Nikolay V. Shabanov, Bin Tan, Piyachat Ratana, Jeffrey L. Privette, Jeffrey T. Morisette, Eric F. Vermote, David P. Roy, Robert E. Wolfe, Mark A. Friedl, Steven W. Running, Petr Votava, Nazmi El-Saleous, Sadashiva Devadiga, Yin Su, and Vincent V. Salomonson Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4820–4823. Published online 2007 March 13. doi: 10.1073/pnas.0611338104.PMCID: PMC1820882 Physics Strong effects of molecular topology on diffusion of entangled DNA molecules Rae M. Robertson and Douglas E. Smith Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4824–4827. Published online 2007 March 13. doi: 10.1073/pnas.0700137104.PMCID: PMC1820884 Sustainability Science Sustainable fuel for the transportation sector Rakesh Agrawal, Navneet R. Singh, Fabio H. Ribeiro, and W. Nicholas Delgass Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4828–4833. Published online 2007 March 14. doi: 10.1073/pnas.0609921104.PMCID: PMC1821126 Biological Sciences Anthropology Phylogeny and ancient DNA of Sus provides insights into neolithic expansion in Island Southeast Asia and Oceania Greger Larson, Thomas Cucchi, Masakatsu Fujita, Elizabeth Matisoo-Smith, Judith Robins, Atholl Anderson, Barry Rolett, Matthew Spriggs, Gaynor Dolman, Tae-Hun Kim, Nguyen Thi Dieu Thuy, Ettore Randi, Moira Doherty, Rokus Awe Due, Robert Bollt, Tony Djubiantono, Bion Griffin, Michiko Intoh, Emile Keane, Patrick Kirch, Kuang-Ti Li, Michael Morwood, Lolita M. Pedriña, Philip J. Piper, Ryan J. Rabett, Peter Shooter, Gert Van den Bergh, Eric West, Stephen Wickler, Jing Yuan, Alan Cooper, and Keith Dobney Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4834–4839. Published online 2007 March 14. doi: 10.1073/pnas.0607753104.PMCID: PMC1829225 Biochemistry Single-molecule measurements of the opening and closing of the DNA gate by eukaryotic topoisomerase II R. Derike Smiley, Tammy R. L. Collins, Gordon G. Hammes, and Tao-Shih Hsieh Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4840–4845. Published online 2007 March 14. doi: 10.1073/pnas.0700342104.PMCID: PMC1829226 Convergent chemical synthesis and high-resolution x-ray structure of human lysozyme Thomas Durek, Vladimir Yu. Torbeev, and Stephen B. H. Kent Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4846–4851. Published online 2007 March 8. doi: 10.1073/pnas.0610630104.PMCID: PMC1829227 Sensitive ChIP-DSL technology reveals an extensive estrogen receptor α-binding program on human gene promoters Young-Soo Kwon, Ivan Garcia-Bassets, Kasey R. Hutt, Christine S. Cheng, Mingjie Jin, Dongyan Liu, Chris Benner, Dong Wang, Zhen Ye, Marina Bibikova, Jian-Bing Fan, Lingxun Duan, Christopher K. Glass, Michael G. Rosenfeld, and Xiang-Dong Fu Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4852–4857. Published online 2007 March 14. doi: 10.1073/pnas.0700715104.PMCID: PMC1821125 Structure of the N-terminal domain of a type B1 G protein-coupled receptor in complex with a peptide ligand Christy Rani R. Grace, Marilyn H. Perrin, Jozsef Gulyas, Michael R. DiGruccio, Jeffrey P. Cantle, Jean E. Rivier, Wylie W. Vale, and Roland Riek Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4858–4863. Published online 2007 March 12. doi: 10.1073/pnas.0700682104.PMCID: PMC1829229 Simultaneous reduction of iron–sulfur protein and cytochrome bL during ubiquinol oxidation in cytochrome bc1 complex Jian Zhu, Tsuyoshi Egawa, Syun-Ru Yeh, Linda Yu, and Chang-An Yu Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4864–4869. Published online 2007 March 13. doi: 10.1073/pnas.0607812104.PMCID: PMC1829230 Inhibitory factors associated with anaphase-promoting complex/cylosome in mitotic checkpoint Ilana Braunstein, Shirly Miniowitz, Yakir Moshe, and Avram Hershko Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4870–4875. Published online 2007 March 13. doi: 10.1073/pnas.0700523104.PMCID: PMC1829231 S-adenosylmethionine directly inhibits binding of 30S ribosomal subunits to the SMK box translational riboswitch RNA Ryan T. Fuchs, Frank J. Grundy, and Tina M. Henkin Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4876–4880. Published online 2007 March 9. doi: 10.1073/pnas.0609956104.PMCID: PMC1829232 Intersubunit movement is required for ribosomal translocation Lucas H. Horan and Harry F. Noller Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4881–4885. Published online 2007 March 8. doi: 10.1073/pnas.0700762104.PMCID: PMC1829233 Reduction of 1-Cys peroxiredoxins by ascorbate changes the thiol-specific antioxidant paradigm, revealing another function of vitamin C Gisele Monteiro, Bruno B. Horta, Daniel Carvalho Pimenta, Ohara Augusto, and Luis E. S. Netto Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4886–4891. Published online 2007 March 14. doi: 10.1073/pnas.0700481104.PMCID: PMC1829234 Biophysics Electronic energy delocalization and dissipation in single- and double-stranded DNA Ivan Buchvarov, Qiang Wang, Milen Raytchev, Anton Trifonov, and Torsten Fiebig Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4794–4797. Published online 2007 March 12. doi: 10.1073/pnas.0606757104.PMCID: PMC1829217 Strong effects of molecular topology on diffusion of entangled DNA molecules Rae M. Robertson and Douglas E. Smith Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4824–4827. Published online 2007 March 13. doi: 10.1073/pnas.0700137104.PMCID: PMC1820884 From the Cover: Single M13 bacteriophage tethering and stretching Ahmad S. Khalil, Jorge M. Ferrer, Ricardo R. Brau, Stephen T. Kottmann, Christopher J. Noren, Matthew J. Lang, and Angela M. Belcher Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4892–4897. Published online 2007 March 13. doi: 10.1073/pnas.0605727104.PMCID: PMC1829235 Accurate, conformation-dependent predictions of solvent effects on protein ionization constants P. Barth, T. Alber, and P. B. Harbury Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4898–4903. Published online 2007 March 14. doi: 10.1073/pnas.0700188104.PMCID: PMC1829236 Collective neuronal growth and self organization of axons P.-G. de Gennes Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4904–4906. Published online 2007 March 12. doi: 10.1073/pnas.0609871104.PMCID: PMC1829237 Predicting coupling limits from an experimentally determined energy landscape Timothy O. Street, Christina M. Bradley, and Doug Barrick Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4907–4912. Published online 2007 March 14. doi: 10.1073/pnas.0608756104.PMCID: PMC1829238 Conformational flexibility in the chromatin remodeler RSC observed by electron microscopy and the orthogonal tilt reconstruction method Andres E. Leschziner, Anjanabha Saha, Jacqueline Wittmeyer, Yongli Zhang, Carlos Bustamante, Bradley R. Cairns, and Eva Nogales Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4913–4918. Published online 2007 March 13. doi: 10.1073/pnas.0700706104.PMCID: PMC1820885 Change in permeant size selectivity by phosphorylation of connexin 43 gap-junctional hemichannels by PKC Xiaoyong Bao, Sung Chang Lee, Luis Reuss, and Guillermo A. Altenberg Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4919–4924. Published online 2007 March 8. doi: 10.1073/pnas.0603154104.PMCID: PMC1817834 Folding free-energy landscape of villin headpiece subdomain from molecular dynamics simulations Hongxing Lei, Chun Wu, Haiguang Liu, and Yong Duan Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4925–4930. Published online 2007 March 12. doi: 10.1073/pnas.0608432104.PMCID: PMC1829241 Key feature of the catalytic cycle of TNF-α converting enzyme involves communication between distal protein sites and the enzyme catalytic core Ariel Solomon, Barak Akabayov, Anatoly Frenkel, Marcos E. Milla, and Irit Sagi Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4931–4936. Published online 2007 March 13. doi: 10.1073/pnas.0700066104.PMCID: PMC1829242 Cytoskeletal dynamics of human erythrocyte Ju Li, George Lykotrafitis, Ming Dao, and Subra Suresh Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4937–4942. Published online 2007 March 12. doi: 10.1073/pnas.0700257104.PMCID: PMC1829243 On the thermodynamic stability of a charged arginine side chain in a transmembrane helix Sudha Dorairaj and Toby W. Allen Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4943–4948. Published online 2007 March 13. doi: 10.1073/pnas.0610470104.PMCID: PMC1829244 Cell Biology A lamin A protein isoform overexpressed in Hutchinson–Gilford progeria syndrome interferes with mitosis in progeria and normal cells Kan Cao, Brian C. Capell, Michael R. Erdos, Karima Djabali, and Francis S. Collins Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4949–4954. Published online 2007 March 14. doi: 10.1073/pnas.0611640104.PMCID: PMC1821129 Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging Thomas Dechat, Takeshi Shimi, Stephen A. Adam, Antonio E. Rusinol, Douglas A. Andres, H. Peter Spielmann, Michael S. Sinensky, and Robert D. Goldman Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4955–4960. Published online 2007 March 14. doi: 10.1073/pnas.0700854104.PMCID: PMC1829246 Loss of androgen receptor binding to selective androgen response elements causes a reproductive phenotype in a knockin mouse model Kris Schauwaers, Karel De Gendt, Philippa T. K. Saunders, Nina Atanassova, Annemie Haelens, Leen Callewaert, Udo Moehren, Johannes V. Swinnen, Guido Verhoeven, Guy Verrijdt, and Frank Claessens Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4961–4966. Published online 2007 March 12. doi: 10.1073/pnas.0610814104.PMCID: PMC1829247 Ecology INAUGURAL ARTICLE by a Recently Elected Academy Member: Inorganic nitrogen availability after severe stand-replacing fire in the Greater Yellowstone ecosystem Monica G. Turner, Erica A. H. Smithwick, Kristine L. Metzger, Daniel B. Tinker, and William H. Romme Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4782–4789. Published online 2007 March 2. doi: 10.1073/pnas.0700180104.PMCID: PMC1829215 From the Cover: DNA barcodes affirm that 16 species of apparently generalist tropical parasitoid flies (Diptera, Tachinidae) are not all generalists M. Alex Smith, D. Monty Wood, Daniel H. Janzen, Winnie Hallwachs, and Paul D. N. Hebert Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4967–4972. Published online 2007 March 14. doi: 10.1073/pnas.0700050104.PMCID: PMC1821123 From the Cover: Tradeoffs between income, biodiversity, and ecosystem functioning during tropical rainforest conversion and agroforestry intensification Ingolf Steffan-Dewenter, Michael Kessler, Jan Barkmann, Merijn M. Bos, Damayanti Buchori, Stefan Erasmi, Heiko Faust, Gerhard Gerold, Klaus Glenk, S. Robbert Gradstein, Edi Guhardja, Marieke Harteveld, Dietrich Hertel, Patrick Höhn, Martin Kappas, Stefan Köhler, Christoph Leuschner, Miet Maertens, Rainer Marggraf, Sonja Migge-Kleian, Johanis Mogea, Ramadhaniel Pitopang, Matthias Schaefer, Stefan Schwarze, Simone G. Sporn, Andrea Steingrebe, Sri S. Tjitrosoedirdjo, Soekisman Tjitrosoemito, André Twele, Robert Weber, Lars Woltmann, Manfred Zeller, and Teja Tscharntke Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4973–4978. Published online 2007 March 14. doi: 10.1073/pnas.0608409104.PMCID: PMC1829249 Phylogenetic signal in plant pathogen–host range Gregory S. Gilbert and Campbell O. Webb Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4979–4983. Published online 2007 March 14. doi: 10.1073/pnas.0607968104.PMCID: PMC1829250 Optimizing the control of disease infestations at the landscape scale Graeme A. Forster and Christopher A. Gilligan Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4984–4989. Published online 2007 March 13. doi: 10.1073/pnas.0607900104.PMCID: PMC1829251 Altered soil microbial community at elevated CO2 leads to loss of soil carbon Karen M. Carney, Bruce A. Hungate, Bert G. Drake, and J. Patrick Megonigal Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4990–4995. Published online 2007 March 13. doi: 10.1073/pnas.0610045104.PMCID: PMC1820881 Evolution Rapid evolution of smell and taste receptor genes during host specialization in Drosophila sechellia Carolyn S. McBride Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4996–5001. Published online 2007 March 9. doi: 10.1073/pnas.0608424104.PMCID: PMC1829253 Global molecular phylogeography reveals persistent Arctic circumpolar isolation in a marine planktonic protist Kate F. Darling, Michal Kucera, and Christopher M. Wade Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5002–5007. Published online 2007 March 13. doi: 10.1073/pnas.0700520104.PMCID: PMC1829254 Innateness and culture in the evolution of language Simon Kirby, Mike Dowman, and Thomas L. Griffiths Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5241–5245. Published online 2007 March 12. doi: 10.1073/pnas.0608222104.PMCID: PMC1829293 Genetics Functional, fractal nonlinear response with application to rate processes with memory, allometry, and population genetics Marcel O. Vlad, Federico Morán, Vlad T. Popa, Stefan E. Szedlacsek, and John Ross Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4798–4803. Published online 2007 March 14. doi: 10.1073/pnas.0700397104.PMCID: PMC1829218 An epigenetic mark generated by the incorporation of CENP-A into centromeric nucleosomes Ben E. Black, Melissa A. Brock, Sabrina Bédard, Virgil L. Woods, Jr., and Don W. Cleveland Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5008–5013. Published online 2007 March 13. doi: 10.1073/pnas.0700390104.PMCID: PMC1829255 A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling Birgit Gerisch, Veerle Rottiers, Dongling Li, Daniel L. Motola, Carolyn L. Cummins, Hans Lehrach, David J. Mangelsdorf, and Adam Antebi Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5014–5019. Published online 2007 March 14. doi: 10.1073/pnas.0700847104.PMCID: PMC1821127 Evidence of spatially bound gene regulation in Mus musculus: Decreased gene expression proximal to microRNA genomic location Hidenori Inaoka, Yutaka Fukuoka, and Isaac S. Kohane Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5020–5025. Published online 2007 March 12. doi: 10.1073/pnas.0611078104.PMCID: PMC1820821 Immunology Lymphotoxin β receptor signaling is required for inflammatory lymphangiogenesis in the thyroid Glaucia C. Furtado, Tatjana Marinkovic, Andrea P. Martin, Alexandre Garin, Benjamin Hoch, Wolfgang Hubner, Benjamin K. Chen, Eric Genden, Mihaela Skobe, and Sergio A. Lira Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5026–5031. Published online 2007 March 14. doi: 10.1073/pnas.0606697104.PMCID: PMC1829258 A model of immune regulation as a consequence of randomized lymphocyte division and death times E. D. Hawkins, M. L. Turner, M. R. Dowling, C. van Gend, and P. D. Hodgkin Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5032–5037. Published online 2007 March 14. doi: 10.1073/pnas.0700026104.PMCID: PMC1821128 Stage-dependent reactivity of thymocytes to self-peptide–MHC complexes Qibin Leng, Qing Ge, Tam Nguyen, Herman N. Eisen, and Jianzhu Chen Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5038–5043. Published online 2007 March 14. doi: 10.1073/pnas.0700674104.PMCID: PMC1829260 Antiviral and immunoregulatory activities of IFN-γ depend on constitutively expressed IL-1α Vladimir Hurgin, Daniela Novick, Ariel Werman, Charles A. Dinarello, and Menachem Rubinstein Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5044–5049. Published online 2007 March 8. doi: 10.1073/pnas.0611608104.PMCID: PMC1817830 Medical Sciences The role of cells refractory to productive infection in acute hepatitis B viral dynamics Stanca M. Ciupe, Ruy M. Ribeiro, Patrick W. Nelson, Geoffrey Dusheiko, and Alan S. Perelson Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5050–5055. Published online 2007 March 14. doi: 10.1073/pnas.0603626104.PMCID: PMC1829262 Osteopenia in X-linked hyper-IgM syndrome reveals a regulatory role for CD40 ligand in osteoclastogenesis Eduardo Lopez-Granados, Stephane T. Temmerman, Lynne Wu, James C. Reynolds, Dean Follmann, Shuying Liu, David L. Nelson, Frank Rauch, and Ashish Jain Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5056–5061. Published online 2007 March 9. doi: 10.1073/pnas.0605715104.PMCID: PMC1817828 Role for CD47-SIRPα signaling in xenograft rejection by macrophages Kentaro Ide, Hui Wang, Hiroyuki Tahara, Jianxiang Liu, Xiaoying Wang, Toshimasa Asahara, Megan Sykes, Yong-Guang Yang, and Hideki Ohdan Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5062–5066. Published online 2007 March 12. doi: 10.1073/pnas.0609661104.PMCID: PMC1829264 Human herpesvirus 6A accelerates AIDS progression in macaques Paolo Lusso, Richard W. Crowley, Mauro S. Malnati, Clelia Di Serio, Maurilio Ponzoni, Angelique Biancotto, Phillip D. Markham, and Robert C. Gallo Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5067–5072. Published online 2007 March 14. doi: 10.1073/pnas.0700929104.PMCID: PMC1829265 Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts Ingmar Meinecke, Antje Cinski, Anja Baier, Marvin A. Peters, Berno Dankbar, Aline Wille, Andreas Drynda, Heidi Mendoza, Renate E. Gay, Ronald T. Hay, Barbara Ink, Steffen Gay, and Thomas Pap Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5073–5078. Published online 2007 March 14. doi: 10.1073/pnas.0608773104.PMCID: PMC1829266 A porphomethene inhibitor of uroporphyrinogen decarboxylase causes porphyria cutanea tarda John D. Phillips, Hector A. Bergonia, Christopher A. Reilly, Michael R. Franklin, and James P. Kushner Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5079–5084. Published online 2007 March 9. doi: 10.1073/pnas.0700547104.PMCID: PMC1820519 From the Cover: Assisted reproductive technologies do not alter mutation frequency or spectrum Lee Caperton, Patricia Murphey, Yukiko Yamazaki, C. Alex McMahan, Christi A. Walter, Ryuzo Yanagimachi, and John R. McCarrey Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5085–5090. Published online 2007 March 2. doi: 10.1073/pnas.0611642104.PMCID: PMC1808421 Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow Linda Yang, Lei Wang, Hartmut Geiger, Jose A. Cancelas, Jun Mo, and Yi Zheng Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5091–5096. Published online 2007 March 12. doi: 10.1073/pnas.0610819104.PMCID: PMC1829299 Noninfectious entry of HIV-1 into peripheral and brain macrophages mediated by the mannose receptor J. Roberto Trujillo, Rick Rogers, Ramon M. Molina, Fernando Dangond, Mary Fran McLane, Max Essex, and Joseph D. Brain Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5097–5102. Published online 2007 March 14. doi: 10.1073/pnas.0611263104.PMCID: PMC1821124 Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis Jennifer P. Morton, Michelle E. Mongeau, David S. Klimstra, John P. Morris, Yie Chia Lee, Yoshiya Kawaguchi, Christopher V. E. Wright, Matthias Hebrok, and Brian C. Lewis Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5103–5108. Published online 2007 March 19. doi: 10.1073/pnas.0701158104.PMCID: PMC1828712 Hypoxia-inducible factor 1α stabilization by carbon monoxide results in cytoprotective preconditioning Beek Y. Chin, Ge Jiang, Barbara Wegiel, Hong J. Wang, Theresa MacDonald, Xu Chen Zhang, David Gallo, Eva Cszimadia, Fritz H. Bach, Patty J. Lee, and Leo E. Otterbein Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5109–5114. Published online 2007 March 12. doi: 10.1073/pnas.0609611104.PMCID: PMC1820823 Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patients Francesco Dotta, Stefano Censini, Astrid G. S. van Halteren, Lorella Marselli, Matilde Masini, Sabrina Dionisi, Franco Mosca, Ugo Boggi, Andrea Onetti Muda, Stefano Del Prato, John F. Elliott, Antonello Covacci, Rino Rappuoli, Bart O. Roep, and Piero Marchetti Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5115–5120. Published online 2007 March 14. doi: 10.1073/pnas.0700442104.PMCID: PMC1829272 Microbiology Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family Simran Banga, Ping Gao, Xihui Shen, Valena Fiscus, Wei-Xing Zong, Lingling Chen, and Zhao-Qing Luo Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5121–5126. Published online 2007 March 14. doi: 10.1073/pnas.0611030104.PMCID: PMC1829273 Distinctive features of large complex virus genomes and proteomes Jan Mrázek and Samuel Karlin Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5127–5132. Published online 2007 March 9. doi: 10.1073/pnas.0700429104.PMCID: PMC1829274 Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling Madhulika Jain, Christopher J. Petzold, Michael W. Schelle, Michael D. Leavell, Joseph D. Mougous, Carolyn R. Bertozzi, Julie A. Leary, and Jeffery S. Cox Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5133–5138. Published online 2007 March 8. doi: 10.1073/pnas.0610634104.PMCID: PMC1829275 Crystal structures reveal a thiol protease-like catalytic triad in the C-terminal region of Pasteurella multocida toxin Kengo Kitadokoro, Shigeki Kamitani, Masayuki Miyazawa, Miyuki Hanajima-Ozawa, Aya Fukui, Masami Miyake, and Yasuhiko Horiguchi Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5139–5144. Published online 2007 March 14. doi: 10.1073/pnas.0608197104.PMCID: PMC1829276 Mycobacterium tuberculosis produces pili during human infection Christopher J. Alteri, Juan Xicohténcatl-Cortes, Sonja Hess, Guillermo Caballero-Olín, Jorge A. Girón, and Richard L. Friedman Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5145–5150. Published online 2007 March 8. doi: 10.1073/pnas.0602304104.PMCID: PMC1817835 Genomic analysis of the Mozambique strain of Vibrio cholerae O1 reveals the origin of El Tor strains carrying classical CTX prophage Shah M. Faruque, Vincent C. Tam, Nityananda Chowdhury, Pornphan Diraphat, Michelle Dziejman, John F. Heidelberg, John D. Clemens, John J. Mekalanos, and G. Balakrish Nair Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5151–5156. Published online 2007 March 12. doi: 10.1073/pnas.0700365104.PMCID: PMC1829278 Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice Apoorva Bhatt, Nagatoshi Fujiwara, Kiranmai Bhatt, Sudagar S. Gurcha, Laurent Kremer, Bing Chen, John Chan, Steven A. Porcelli, Kazuo Kobayashi, Gurdyal S. Besra, and William R. Jacobs, Jr. Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5157–5162. Published online 2007 March 12. doi: 10.1073/pnas.0608654104.PMCID: PMC1829279 Neuroscience From the Cover: Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand Blaine N. Armbruster, Xiang Li, Mark H. Pausch, Stefan Herlitze, and Bryan L. Roth Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5163–5168. Published online 2007 March 2. doi: 10.1073/pnas.0700293104.PMCID: PMC1829280 Differential responses of hippocampal subfields to cortical up–down states Thomas T. G. Hahn, Bert Sakmann, and Mayank R. Mehta Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5169–5174. Published online 2007 March 12. doi: 10.1073/pnas.0700222104.PMCID: PMC1829281 First-spike latency information in single neurons increases when referenced to population onset Steven M. Chase and Eric D. Young Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5175–5180. Published online 2007 March 9. doi: 10.1073/pnas.0610368104.PMCID: PMC1829282 Prefrontal/accumbal catecholamine system determines motivational salience attribution to both reward- and aversion-related stimuli Rossella Ventura, Cristina Morrone, and Stefano Puglisi-Allegra Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5181–5186. Published online 2007 March 9. doi: 10.1073/pnas.0610178104.PMCID: PMC1820518 Dopamine modulation of neuronal Na+ channels requires binding of A kinase-anchoring protein 15and PKA by a modified leucine zipper motif W. Preston Few, Todd Scheuer, and William A. Catterall Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5187–5192. Published online 2007 March 14. doi: 10.1073/pnas.0611619104.PMCID: PMC1829284 Cerebellar GABAergic progenitors adopt an external granule cell-like phenotype in the absence of Ptf1a transcription factor expression Marta Pascual, Ibane Abasolo, Ana Mingorance-Le Meur, Albert Martínez, José A. Del Rio, Christopher V. E. Wright, Francisco X. Real, and Eduardo Soriano Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5193–5198. Published online 2007 March 14. doi: 10.1073/pnas.0605699104.PMCID: PMC1829285 Peripheral multidendritic sensory neurons are necessary for rhythmic locomotion behavior in Drosophila larvae Wei Song, Maika Onishi, Lily Yeh Jan, and Yuh Nung Jan Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5199–5204. Published online 2007 March 13. doi: 10.1073/pnas.0700895104.PMCID: PMC1820883 A genomic screen for activators of the antioxidant response element Yanxia Liu, Jonathan T. Kern, John R. Walker, Jeffrey A. Johnson, Peter G. Schultz, and Hendrik Luesch Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5205–5210. Published online 2007 March 12. doi: 10.1073/pnas.0700898104.PMCID: PMC1829287 Neural correlates of perceptual filling-in of an artificial scotoma in humans R. S. Weil, J. M. Kilner, J. D. Haynes, and G. Rees Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5211–5216. Published online 2007 March 14. doi: 10.1073/pnas.0609294104.PMCID: PMC1829288 Physiology Genetic deletion of p66Shc adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress Giovanni G. Camici, Marzia Schiavoni, Pietro Francia, Markus Bachschmid, Ines Martin-Padura, Martin Hersberger, Felix C. Tanner, PierGiuseppe Pelicci, Massimo Volpe, Piero Anversa, Thomas F. Lüscher, and Francesco Cosentino Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5217–5222. Published online 2007 March 14. doi: 10.1073/pnas.0609656104.PMCID: PMC1829289 PGC-1β controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis Junichiro Sonoda, Isaac R. Mehl, Ling-Wa Chong, Russell R. Nofsinger, and Ronald M. Evans Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5223–5228. Published online 2007 March 12. doi: 10.1073/pnas.0611623104.PMCID: PMC1829290 Absence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice Gloria I. Perez, Andrea Jurisicova, Lisa Wise, Tatiana Lipina, Marijana Kanisek, Allison Bechard, Yasushi Takai, Patricia Hunt, John Roder, Marc Grynpas, and Jonathan L. Tilly Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5229–5234. Published online 2007 March 8. doi: 10.1073/pnas.0608557104.PMCID: PMC1817832 Ca2+ sparks operated by membrane depolarization require isoform 3 ryanodine receptor channels in skeletal muscle Sandrine Pouvreau, Leandro Royer, Jianxun Yi, Gustavo Brum, Gerhard Meissner, Eduardo Ríos, and Jingsong Zhou Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5235–5240. Published online 2007 March 14. doi: 10.1073/pnas.0700748104.PMCID: PMC1829292 Social Sciences Anthropology Phylogeny and ancient DNA of Sus provides insights into neolithic expansion in Island Southeast Asia and Oceania Greger Larson, Thomas Cucchi, Masakatsu Fujita, Elizabeth Matisoo-Smith, Judith Robins, Atholl Anderson, Barry Rolett, Matthew Spriggs, Gaynor Dolman, Tae-Hun Kim, Nguyen Thi Dieu Thuy, Ettore Randi, Moira Doherty, Rokus Awe Due, Robert Bollt, Tony Djubiantono, Bion Griffin, Michiko Intoh, Emile Keane, Patrick Kirch, Kuang-Ti Li, Michael Morwood, Lolita M. Pedriña, Philip J. Piper, Ryan J. Rabett, Peter Shooter, Gert Van den Bergh, Eric West, Stephen Wickler, Jing Yuan, Alan Cooper, and Keith Dobney Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4834–4839. Published online 2007 March 14. doi: 10.1073/pnas.0607753104.PMCID: PMC1829225 Psychology Innateness and culture in the evolution of language Simon Kirby, Mike Dowman, and Thomas L. Griffiths Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5241–5245. Published online 2007 March 12. doi: 10.1073/pnas.0608222104.PMCID: PMC1829293 Compatibility of basic social perceptions determines perceived attractiveness Kerri L. Johnson and Louis G. Tassinary Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5246–5251. Published online 2007 March 13. doi: 10.1073/pnas.0608181104.PMCID: PMC1829294 Sustainability Science From the Cover: Tradeoffs between income, biodiversity, and ecosystem functioning during tropical rainforest conversion and agroforestry intensification Ingolf Steffan-Dewenter, Michael Kessler, Jan Barkmann, Merijn M. Bos, Damayanti Buchori, Stefan Erasmi, Heiko Faust, Gerhard Gerold, Klaus Glenk, S. Robbert Gradstein, Edi Guhardja, Marieke Harteveld, Dietrich Hertel, Patrick Höhn, Martin Kappas, Stefan Köhler, Christoph Leuschner, Miet Maertens, Rainer Marggraf, Sonja Migge-Kleian, Johanis Mogea, Ramadhaniel Pitopang, Matthias Schaefer, Stefan Schwarze, Simone G. Sporn, Andrea Steingrebe, Sri S. Tjitrosoedirdjo, Soekisman Tjitrosoemito, André Twele, Robert Weber, Lars Woltmann, Manfred Zeller, and Teja Tscharntke Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 4973–4978. Published online 2007 March 14. doi: 10.1073/pnas.0608409104.PMCID: PMC1829249 Correction Correction for Hebbeln et al., Biotin uptake in prokaryotes by solute transporters with an optional ATP-binding cassette-containing module Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5252. Published online 2007 March 9. doi: 10.1073/pnas.0701704104.PMCID: PMC1829295 Corrects: Peter Hebbeln, et al. Biotin uptake in prokaryotes by solute transporters with an optional ATP-binding cassette-containing module. Proc Natl Acad Sci U S A. 2007 February 20; 104(8): 2909–2914. |