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Volume 104(6);  February 6, 2007
This Week in PNAS
In This Issue
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1735–1736. doi: 10.1073/iti0607104.
PMCID: PMC1794317
Editorial
Sustainability Science: A room of its own
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1737–1738. doi: 10.1073/pnas.0611291104.
PMCID: PMC1794267
Commentaries
The incredible, edible, and therapeutic egg
James N. Petitte and Paul E. Mozdziak
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1739–1740. Published online 2007 February 1. doi: 10.1073/pnas.0611652104.
PMCID: PMC1794276
Synthetic ecology: A model system for cooperation
Maitreya J. Dunham
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1741–1742. Published online 2007 January 31. doi: 10.1073/pnas.0611067104.
PMCID: PMC1794274
Malarial fever: Hemozoin is involved but Toll-free
Ralf R. Schumann
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1743–1744. Published online 2007 February 1. doi: 10.1073/pnas.0610874104.
PMCID: PMC1794284
Perspective
Embryo stability and vulnerability in an always changing world
Amro Hamdoun and David Epel
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1745–1750. Published online 2007 January 30. doi: 10.1073/pnas.0610108104.
PMCID: PMC1794293
Profile
Profile of James P. Kennett
Tinsley H. Davis
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1751–1753. Published online 2007 January 31. doi: 10.1073/pnas.0609142104.
PMCID: PMC1794309
Physical Sciences
Applied Mathematics
From the Cover:
Synthetic cooperation in engineered yeast populations
Wenying Shou, Sri Ram, and Jose M. G. Vilar
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1877–1882. Published online 2007 January 31. doi: 10.1073/pnas.0610575104.
PMCID: PMC1794266
Applied Physical Sciences
Hyperpolarized water as an authentic magnetic resonance imaging contrast agent
Evan R. McCarney, Brandon D. Armstrong, Mark D. Lingwood, and Songi Han
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1754–1759. Published online 2007 January 30. doi: 10.1073/pnas.0610540104.
PMCID: PMC1794264
Physics
From the Cover:
Complex network analysis of free-energy landscapes
D. Gfeller, P. De Los Rios, A. Caflisch, and F. Rao
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1817–1822. Published online 2007 January 31. doi: 10.1073/pnas.0608099104.
PMCID: PMC1794291
Statistics
Sequential Monte Carlo without likelihoods
S. A. Sisson, Y. Fan, and Mark M. Tanaka
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1760–1765. Published online 2007 January 30. doi: 10.1073/pnas.0607208104.
PMCID: PMC1794282
Biological Sciences
Agricultural Sciences
Transgenic induction of mitochondrial rearrangements for cytoplasmic male sterility in crop plants
Ajay Pal S. Sandhu, Ricardo V. Abdelnoor, and Sally A. Mackenzie
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1766–1770. Published online 2007 January 29. doi: 10.1073/pnas.0609344104.
PMCID: PMC1783905
Applied Biological Sciences
From the Cover:
Oviduct-specific expression of two therapeutic proteins in transgenic hens
S. G. Lillico, A. Sherman, M. J. McGrew, C. D. Robertson, J. Smith, C. Haslam, P. Barnard, P. A. Radcliffe, K. A. Mitrophanous, E. A. Elliot, and H. M. Sang
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1771–1776. Published online 2007 January 26. doi: 10.1073/pnas.0610401104.
PMCID: PMC1783527
Global reconstruction of the human metabolic network based on genomic and bibliomic data
Natalie C. Duarte, Scott A. Becker, Neema Jamshidi, Ines Thiele, Monica L. Mo, Thuy D. Vo, Rohith Srivas, and Bernhard Ø. Palsson
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1777–1782. Published online 2007 January 31. doi: 10.1073/pnas.0610772104.
PMCID: PMC1794290
Biochemistry
Crystal structure of the N-terminal domain of the human protooncogene Nup214/CAN
Johanna Napetschnig, Günter Blobel, and André Hoelz
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1783–1788. Published online 2007 January 30. doi: 10.1073/pnas.0610828104.
PMCID: PMC1794303
Substrate interactions with human ferrochelatase
Amy Medlock, Larkin Swartz, Tamara A. Dailey, Harry A. Dailey, and William N. Lanzilotta
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1789–1793. Published online 2007 January 29. doi: 10.1073/pnas.0606144104.
PMCID: PMC1794275
Inorganic polyphosphate essential for lytic growth of phages P1 and fd
Li Li, Narayana N. Rao, and Arthur Kornberg
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1794–1799. Published online 2007 January 29. doi: 10.1073/pnas.0610763104.
PMCID: PMC1794287
Effect of phosphorylation and S–S bond-induced dimerization on DNA binding and transcriptional activation by C/EBPβ
Jae-woo Kim, Qi-Qun Tang, Xi Li, and M. Daniel Lane
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1800–1804. Published online 2007 January 30. doi: 10.1073/pnas.0611137104.
PMCID: PMC1794285
SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5
Mark D. Benson, Qiu-Ju Li, Katherine Kieckhafer, David Dudek, Matthew R. Whorton, Roger K. Sunahara, Jorge A. Iñiguez-Lluhí, and Jeffrey R. Martens
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1805–1810. Published online 2007 January 29. doi: 10.1073/pnas.0606702104.
PMCID: PMC1794304
The tail of the ParG DNA segregation protein remodels ParF polymers and enhances ATP hydrolysis via an arginine finger-like motif
Daniela Barillà, Emma Carmelo, and Finbarr Hayes
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1811–1816. Published online 2007 January 29. doi: 10.1073/pnas.0607216104.
PMCID: PMC1794263
Biophysics
From the Cover:
Complex network analysis of free-energy landscapes
D. Gfeller, P. De Los Rios, A. Caflisch, and F. Rao
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1817–1822. Published online 2007 January 31. doi: 10.1073/pnas.0608099104.
PMCID: PMC1794291
The optimal height of the synaptic cleft
Leonid P. Savtchenko and Dmitri A. Rusakov
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1823–1828. Published online 2007 January 29. doi: 10.1073/pnas.0606636104.
PMCID: PMC1783902
Cell Biology
Protective role of autophagy against Vibrio cholerae cytolysin, a pore-forming toxin from V. cholerae
Maximiliano Gabriel Gutierrez, Hector Alex Saka, Isabel Chinen, Felipe C. M. Zoppino, Tamotsu Yoshimori, Jose Luis Bocco, and María Isabel Colombo
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1829–1834. Published online 2007 January 31. doi: 10.1073/pnas.0601437104.
PMCID: PMC1794277
Lack of myostatin results in excessive muscle growth but impaired force generation
Helge Amthor, Raymond Macharia, Roberto Navarrete, Markus Schuelke, Susan C. Brown, Anthony Otto, Thomas Voit, Francesco Muntoni, Gerta Vrbóva, Terence Partridge, Peter Zammit, Lutz Bunger, and Ketan Patel
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1835–1840. Published online 2007 January 31. doi: 10.1073/pnas.0604893104.
PMCID: PMC1794294
BLIMP1 regulates cell growth through repression of p53 transcription
Junli Yan, Jianming Jiang, Ching Aeng Lim, Qiang Wu, Huck-Hui Ng, and Keh-Chuang Chin
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1841–1846. Published online 2007 January 30. doi: 10.1073/pnas.0605562104.
PMCID: PMC1784014
Polo-like kinase 3 is required for entry into S phase
Wendy C. Zimmerman and Raymond L. Erikson
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1847–1852. Published online 2007 January 30. doi: 10.1073/pnas.0610856104.
PMCID: PMC1794279
Influenza virus targets the mRNA export machinery and the nuclear pore complex
Neal Satterly, Pei-Ling Tsai, Jan van Deursen, Daniel R. Nussenzveig, Yaming Wang, Paula A. Faria, Agata Levay, David E. Levy, and Beatriz M. A. Fontoura
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1853–1858. Published online 2007 January 31. doi: 10.1073/pnas.0610977104.
PMCID: PMC1794296
LARK activates posttranscriptional expression of an essential mammalian clock protein, PERIOD1
Shihoko Kojima, Ken Matsumoto, Matsumi Hirose, Miyuki Shimada, Mamoru Nagano, Yasufumi Shigeyoshi, Shin-ichi Hoshino, Kumiko Ui-Tei, Kaoru Saigo, Carla B. Green, Yoshiyuki Sakaki, and Hajime Tei
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1859–1864. Published online 2007 January 30. doi: 10.1073/pnas.0607567104.
PMCID: PMC1794262
Developmental Biology
From the Cover:
SOX9 is required for maintenance of the pancreatic progenitor cell pool
Philip A. Seymour, Kristine K. Freude, Man N. Tran, Erin E. Mayes, Jan Jensen, Ralf Kist, Gerd Scherer, and Maike Sander
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1865–1870. Published online 2007 January 31. doi: 10.1073/pnas.0609217104.
PMCID: PMC1794281
Maternal neoangiogenesis during pregnancy partly derives from fetal endothelial progenitor cells
Sau Nguyen Huu, Michèle Oster, Serge Uzan, Fabrice Chareyre, Sélim Aractingi, and Kiarash Khosrotehrani
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1871–1876. Published online 2007 January 31. doi: 10.1073/pnas.0606490104.
PMCID: PMC1794298
Ecology
From the Cover:
Synthetic cooperation in engineered yeast populations
Wenying Shou, Sri Ram, and Jose M. G. Vilar
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1877–1882. Published online 2007 January 31. doi: 10.1073/pnas.0610575104.
PMCID: PMC1794266
Genome dynamics in a natural archaeal population
Eric E. Allen, Gene W. Tyson, Rachel J. Whitaker, John C. Detter, Paul M. Richardson, and Jillian F. Banfield
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1883–1888. Published online 2007 January 31. doi: 10.1073/pnas.0604851104.
PMCID: PMC1794283
Evolution
Antioxidant defense response in a galling insect
Omprakash Mittapalli, Jonathan J. Neal, and Richard H. Shukle
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1889–1894. Published online 2007 January 29. doi: 10.1073/pnas.0604722104.
PMCID: PMC1783901
Massive amplification of rolling-circle transposons in the lineage of the bat Myotis lucifugus
Ellen J. Pritham and Cédric Feschotte
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1895–1900. Published online 2007 January 29. doi: 10.1073/pnas.0609601104.
PMCID: PMC1794268
Genetics
Chromosomal context directs high-frequency precise excision of IS492 in Pseudoalteromonas atlantica
Brian P. Higgins, Chandra D. Carpenter, and Anna C. Karls
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1901–1906. Published online 2007 January 30. doi: 10.1073/pnas.0608633104.
PMCID: PMC1794265
An editing-defective aminoacyl-tRNA synthetase is mutagenic in aging bacteria via the SOS response
Jamie M. Bacher and Paul Schimmel
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1907–1912. Published online 2007 January 30. doi: 10.1073/pnas.0610835104.
PMCID: PMC1794292
Immunology
NF-κB prevents β cell death and autoimmune diabetes in NOD mice
Sunshin Kim, Isabelle Millet, Hun Sik Kim, Ja Young Kim, Myoung Sook Han, Moon-Kyu Lee, Kwang-Won Kim, Robert S. Sherwin, Michael Karin, and Myung-Shik Lee
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1913–1918. Published online 2007 January 31. doi: 10.1073/pnas.0610690104.
PMCID: PMC1794308
Medical Sciences
From the Cover:
Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9
Peggy Parroche, Fanny N. Lauw, Nadege Goutagny, Eicke Latz, Brian G. Monks, Alberto Visintin, Kristen A. Halmen, Marc Lamphier, Martin Olivier, Daniella C. Bartholomeu, Ricardo T. Gazzinelli, and Douglas T. Golenbock
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1919–1924. Published online 2007 January 29. doi: 10.1073/pnas.0608745104.
PMCID: PMC1794278
Noninvasive and real-time assessment of reconstructed functional human endometrium in NOD/SCID/γcnull immunodeficient mice
Hirotaka Masuda, Tetsuo Maruyama, Emi Hiratsu, Junichi Yamane, Akio Iwanami, Takashi Nagashima, Masanori Ono, Hiroyuki Miyoshi, Hirotaka James Okano, Mamoru Ito, Norikazu Tamaoki, Tatsuji Nomura, Hideyuki Okano, Yumi Matsuzaki, and Yasunori Yoshimura
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1925–1930. Published online 2007 January 29. doi: 10.1073/pnas.0604310104.
PMCID: PMC1794295
Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2
Emanuela Giacometti, Sandra Luikenhuis, Caroline Beard, and Rudolf Jaenisch
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1931–1936. Published online 2007 January 31. doi: 10.1073/pnas.0610593104.
PMCID: PMC1794312
Positron emission tomography with computed tomography imaging of neuroinflammation in experimental autoimmune encephalomyelitis
Caius G. Radu, Chengyi J. Shu, Stephanie M. Shelly, Michael E. Phelps, and Owen N. Witte
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1937–1942. Published online 2007 January 29. doi: 10.1073/pnas.0610544104.
PMCID: PMC1783904
Potentiation of mammary cancer inhibition by combination of antagonists of growth hormone-releasing hormone with docetaxel
Stefan Buchholz, Andrew V. Schally, Jörg B. Engel, Florian Hohla, Elmar Heinrich, Frank Koester, Jozsef L. Varga, and Gabor Halmos
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1943–1946. Published online 2007 January 29. doi: 10.1073/pnas.0610860104.
PMCID: PMC1794297
Microbiology
A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages
Robert Van der Geize, Katherine Yam, Thomas Heuser, Maarten H. Wilbrink, Hirofumi Hara, Matthew C. Anderton, Edith Sim, Lubbert Dijkhuizen, Julian E. Davies, William W. Mohn, and Lindsay D. Eltis
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1947–1952. Published online 2007 January 30. doi: 10.1073/pnas.0605728104.
PMCID: PMC1794314
Neuroscience
Relational representation in the olfactory system
Thomas A. Cleland, Brett A. Johnson, Michael Leon, and Christiane Linster
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1953–1958. Published online 2007 January 29. doi: 10.1073/pnas.0608564104.
PMCID: PMC1794271
Axonal-SMN (a-SMN), a protein isoform of the survival motor neuron gene, is specifically involved in axonogenesis
Veronica Setola, Mineko Terao, Denise Locatelli, Stefania Bassanini, Enrico Garattini, and Giorgio Battaglia
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1959–1964. Published online 2007 January 29. doi: 10.1073/pnas.0610660104.
PMCID: PMC1794299
Cells infected with scrapie and Creutzfeldt–Jakob disease agents produce intracellular 25-nm virus-like particles
Laura Manuelidis, Zhoa-Xue Yu, Nuria Barquero, and Brian Mullins
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1965–1970. Published online 2007 January 31. doi: 10.1073/pnas.0610999104.
PMCID: PMC1794316
APL-1, a Caenorhabditis elegans protein related to the human β-amyloid precursor protein, is essential for viability
Angela Hornsten, Jason Lieberthal, Shruti Fadia, Richard Malins, Lawrence Ha, Xiaomeng Xu, Isabelle Daigle, Mindy Markowitz, Gregory O'Connor, Ronald Plasterk, and Chris Li
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1971–1976. Published online 2007 January 31. doi: 10.1073/pnas.0603997104.
PMCID: PMC1794273
GSTπ expression mediates dopaminergic neuron sensitivity in experimental parkinsonism
Michelle Smeyne, Justin Boyd, Kennie Raviie Shepherd, Yun Jiao, Brooks Barnes Pond, Matthew Hatler, Roland Wolf, Colin Henderson, and Richard Jay Smeyne
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1977–1982. Published online 2007 January 31. doi: 10.1073/pnas.0610978104.
PMCID: PMC1785361
The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington's and prion diseases
Andrew D. Steele, Walker S. Jackson, Oliver D. King, and Susan Lindquist
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1983–1988. Published online 2007 January 29. doi: 10.1073/pnas.0610779104.
PMCID: PMC1794260
Nucleus- and cell-specific gene expression in monkey thalamus
Karl D. Murray, Prabhakara V. Choudary, and Edward G. Jones
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1989–1994. Published online 2007 January 29. doi: 10.1073/pnas.0610742104.
PMCID: PMC1783903
mGluR5 stimulates gliotransmission in the nucleus accumbens
Marcello D'Ascenzo, Tommaso Fellin, Miho Terunuma, Raquel Revilla-Sanchez, David F. Meaney, Yves P. Auberson, Stephen J. Moss, and Philip G. Haydon
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1995–2000. Published online 2007 January 26. doi: 10.1073/pnas.0609408104.
PMCID: PMC1794302
Pharmacology
Structural basis for nucleotide exchange on Gαi subunits and receptor coupling specificity
Christopher A. Johnston and David P. Siderovski
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 2001–2006. Published online 2007 January 30. doi: 10.1073/pnas.0608599104.
PMCID: PMC1794300
Physiology
Age-dependent regulation of chromaffin cell proliferation by growth factors, dehydroepiandrosterone (DHEA), and DHEA sulfate
Flavie Sicard, Monika Ehrhart-Bornstein, Denis Corbeil, Simone Sperber, Alexander W. Krug, Christian G. Ziegler, Valeria Rettori, Samuel M. McCann, and Stefan R. Bornstein
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 2007–2012. Published online 2007 January 30. doi: 10.1073/pnas.0610898104.
PMCID: PMC1794270
Substance P mediates antiapoptotic responses in human colonocytes by Akt activation
Hon-Wai Koon, Dezheng Zhao, Yanai Zhan, Mary P. Moyer, and Charalabos Pothoulakis
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 2013–2018. Published online 2007 January 30. doi: 10.1073/pnas.0610664104.
PMCID: PMC1794289
Plant Biology
A plant porphyria related to defects in plastid import of protochlorophyllide oxidoreductase A
Stephan Pollmann, Armin Springer, Frank Buhr, Abder Lahroussi, Iga Samol, Jean-Marc Bonneville, Gabrielle Tichtinsky, Diter von Wettstein, Christiane Reinbothe, and Steffen Reinbothe
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 2019–2023. Published online 2007 January 29. doi: 10.1073/pnas.0610934104.
PMCID: PMC1794315
Corrections
Correction for Zeri et al., Structure of the coat protein in fd filamentous bacteriophage particles determined by solid-state NMR spectroscopy
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 2024. Published online 2007 January 22. doi: 10.1073/pnas.0610764104.
PMCID: PMC1794269
Corrects: Ana Carolina Zeri, et al. Structure of the coat protein in fd filamentous bacteriophage particles determined by solid-state NMR spectroscopy. Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6458–6463.
Correction for Wang et al., Bcl10 plays a critical role in NF-κB activation induced by G protein-coupled receptors
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 2024. Published online 2007 January 22. doi: 10.1073/pnas.0611566104.
PMCID: PMC1794305
Corrects: Donghai Wang, et al. Bcl10 plays a critical role in NF-κB activation induced by G protein-coupled receptors. Proc Natl Acad Sci U S A. 2007 January 2; 104(1): 145–150.
Correction for Wedmann et al., The first fossil leaf insect: 47 million years of specialized cryptic morphology and behavior
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 2024. Published online 2007 January 22. doi: 10.1073/pnas.0700092104.
PMCID: PMC1794313
Corrects: Sonja Wedmann, et al. The first fossil leaf insect: 47 million years of specialized cryptic morphology and behavior. Proc Natl Acad Sci U S A. 2007 January 9; 104(2): 565–569.
Correction for Casola et al., Tracking germinal center B cells expressing germ-line immunoglobulin γ1 transcripts by conditional gene targeting
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 2025. Published online 2007 January 16. doi: 10.1073/pnas.0611564104.
PMCID: PMC1794272
Corrects: Stefano Casola, et al. Tracking germinal center B cells expressing germ-line immunoglobulin γ1 transcripts by conditional gene targeting. Proc Natl Acad Sci U S A. 2006 May 9; 103(19): 7396–7401.
Correction for Galkin et al., Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK
Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 2025. Published online 2007 January 16. doi: 10.1073/pnas.0611563104.
PMCID: PMC1794286
Corrects: Anna V. Galkin, et al. Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proc Natl Acad Sci U S A. 2007 January 2; 104(1): 270–275.
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