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Volume 103(46);  November 14, 2006
This Week in PNAS
In This Issue
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17067–17068. doi: 10.1073/iti4606103.
PMCID: PMC1859887
Commentaries
Hedgehogs like it sweet, too
Andrew Beenken and Moosa Mohammadi
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17069–17070. Published online 2006 November 6. doi: 10.1073/pnas.0608456103.
PMCID: PMC1859888
Germ cells carry the epigenetic benefits of grandmother's diet
Craig A. Cooney
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17071–17072. Published online 2006 November 13. doi: 10.1073/pnas.0608653103.
PMCID: PMC1859889
Circulating tumor cells in breast cancer: Advanced tools for “tailored” therapy?
Massimo Cristofanilli and John Mendelsohn
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17073–17074. Published online 2006 November 7. doi: 10.1073/pnas.0608651103.
PMCID: PMC1859890
Perspective
Nobel Lecture
War and peace
Robert J. Aumann
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17075–17078. Published online 2006 November 8. doi: 10.1073/pnas.0608329103.
PMCID: PMC1859891
Nitrogen Fixation Special Feature
Introductory Perspective
Reduction of dinitrogen
Richard R. Schrock
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17087. Published online 2006 November 6. doi: 10.1073/pnas.0603633103.
PMCID: PMC1859893
Research Articles
Inner-sphere two-electron reduction leads to cleavage and functionalization of coordinated dinitrogen
Liam P. Spencer, Bruce A. MacKay, Brian O. Patrick, and Michael D. Fryzuk
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17094–17098. Published online 2006 October 18. doi: 10.1073/pnas.0602132103.
PMCID: PMC1693869
Catalytic reduction of dinitrogen to ammonia at a single molybdenum center
Walter W. Weare, Xuliang Dai, Matthew J. Byrnes, Jia Min Chin, Richard R. Schrock, and Peter Müller
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17099–17106. Published online 2006 November 3. doi: 10.1073/pnas.0602778103.
PMCID: PMC1693870
On the feasibility of N2 fixation via a single-site FeI/FeIV cycle: Spectroscopic studies of FeI(N2)FeI, FeIVAn external file that holds a picture, illustration, etc., usually as some form of binary object. The name of referred object is cjs0809.jpgN, and related species
Michael P. Hendrich, William Gunderson, Rachel K. Behan, Michael T. Green, Mark P. Mehn, Theodore A. Betley, Connie C. Lu, and Jonas C. Peters
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17107–17112. Published online 2006 November 7. doi: 10.1073/pnas.0604402103.
PMCID: PMC1693871
A methyldiazene (HNAn external file that holds a picture, illustration, etc., usually as some form of binary object. The name of referred object is cjs0808.jpgNAn external file that holds a picture, illustration, etc., usually as some form of binary object. The name of referred object is cjs0807.jpgCH3)-derived species bound to the nitrogenase active-site FeMo cofactor: Implications for mechanism
Brett M. Barney, Dmitriy Lukoyanov, Tran-Chin Yang, Dennis R. Dean, Brian M. Hoffman, and Lance C. Seefeldt
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17113–17118. Published online 2006 November 6. doi: 10.1073/pnas.0602130103.
PMCID: PMC1693872
From the Cover: Nitrogen Fixation Special Feature:
FeMo cofactor maturation on NifEN
Yilin Hu, Mary C. Corbett, Aaron W. Fay, Jerome A. Webber, Keith O. Hodgson, Britt Hedman, and Markus W. Ribbe
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17119–17124. Published online 2006 October 18. doi: 10.1073/pnas.0602647103.
PMCID: PMC1859895
From the Cover: Nitrogen Fixation Special Feature:
Nitrogenase Fe protein: A molybdate/homocitrate insertase
Yilin Hu, Mary C. Corbett, Aaron W. Fay, Jerome A. Webber, Keith O. Hodgson, Britt Hedman, and Markus W. Ribbe
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17125–17130. Published online 2006 October 24. doi: 10.1073/pnas.0602651103.
PMCID: PMC1859896
Flavodoxin hydroquinone reduces Azotobacter vinelandii Fe protein to the all-ferrous redox state with a S = 0 spin state
Thomas J. Lowery, Phillip E. Wilson, Bo Zhang, Jared Bunker, Roger G. Harrison, Andrew C. Nyborg, David Thiriot, and Gerald D. Watt
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17131–17136. Published online 2006 November 3. doi: 10.1073/pnas.0603223103.
PMCID: PMC1859897
Perspective
How many metals does it take to fix N2? A mechanistic overview of biological nitrogen fixation
James B. Howard and Douglas C. Rees
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17088–17093. Published online 2006 November 6. doi: 10.1073/pnas.0603978103.
PMCID: PMC1859894
Physical Sciences
Applied Physical Sciences
Adaptive wavefront correction in two-photon microscopy using coherence-gated wavefront sensing
Markus Rueckel, Julia A. Mack-Bucher, and Winfried Denk
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17137–17142. Published online 2006 November 6. doi: 10.1073/pnas.0604791103.
PMCID: PMC1634839
Quantitative multispectral biosensing and 1D imaging using quasi-3D plasmonic crystals
Matthew E. Stewart, Nathan H. Mack, Viktor Malyarchuk, Julio A. N. T. Soares, Tae-Woo Lee, Stephen K. Gray, Ralph G. Nuzzo, and John A. Rogers
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17143–17148. Published online 2006 November 3. doi: 10.1073/pnas.0606216103.
PMCID: PMC1634412
Two-photon vibrational spectroscopy for biosciences based on surface-enhanced hyper-Raman scattering
Janina Kneipp, Harald Kneipp, and Katrin Kneipp
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17149–17153. Published online 2006 November 6. doi: 10.1073/pnas.0608262103.
PMCID: PMC1634837
Chemistry
Inner-sphere two-electron reduction leads to cleavage and functionalization of coordinated dinitrogen
Liam P. Spencer, Bruce A. MacKay, Brian O. Patrick, and Michael D. Fryzuk
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17094–17098. Published online 2006 October 18. doi: 10.1073/pnas.0602132103.
PMCID: PMC1693869
Catalytic reduction of dinitrogen to ammonia at a single molybdenum center
Walter W. Weare, Xuliang Dai, Matthew J. Byrnes, Jia Min Chin, Richard R. Schrock, and Peter Müller
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17099–17106. Published online 2006 November 3. doi: 10.1073/pnas.0602778103.
PMCID: PMC1693870
On the feasibility of N2 fixation via a single-site FeI/FeIV cycle: Spectroscopic studies of FeI(N2)FeI, FeIVAn external file that holds a picture, illustration, etc., usually as some form of binary object. The name of referred object is cjs0809.jpgN, and related species
Michael P. Hendrich, William Gunderson, Rachel K. Behan, Michael T. Green, Mark P. Mehn, Theodore A. Betley, Connie C. Lu, and Jonas C. Peters
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17107–17112. Published online 2006 November 7. doi: 10.1073/pnas.0604402103.
PMCID: PMC1693871
A methyldiazene (HNAn external file that holds a picture, illustration, etc., usually as some form of binary object. The name of referred object is cjs0808.jpgNAn external file that holds a picture, illustration, etc., usually as some form of binary object. The name of referred object is cjs0807.jpgCH3)-derived species bound to the nitrogenase active-site FeMo cofactor: Implications for mechanism
Brett M. Barney, Dmitriy Lukoyanov, Tran-Chin Yang, Dennis R. Dean, Brian M. Hoffman, and Lance C. Seefeldt
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17113–17118. Published online 2006 November 6. doi: 10.1073/pnas.0602130103.
PMCID: PMC1693872
The color of rhodopsins at the ab initio multiconfigurational perturbation theory resolution
Pedro B. Coto, Angela Strambi, Nicolas Ferré, and Massimo Olivucci
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17154–17159. Published online 2006 November 7. doi: 10.1073/pnas.0604048103.
PMCID: PMC1859901
Concatenated logic gates using four coupled biocatalysts operating in series
Tamara Niazov, Ronan Baron, Eugenii Katz, Oleg Lioubashevski, and Itamar Willner
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17160–17163. Published online 2006 November 6. doi: 10.1073/pnas.0608319103.
PMCID: PMC1634834
Engineering
Blood flow velocity effects and role of activation delay time on growth and form of platelet thrombi
Igor V. Pivkin, Peter D. Richardson, and George Karniadakis
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17164–17169. Published online 2006 November 3. doi: 10.1073/pnas.0608546103.
PMCID: PMC1859903
Environmental Sciences
The potential rate of bed-load transport
Basil Gomez
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17170–17173. Published online 2006 November 6. doi: 10.1073/pnas.0608487103.
PMCID: PMC1859904
Bacterial metapopulations in nanofabricated landscapes
Juan E. Keymer, Peter Galajda, Cecilia Muldoon, Sungsu Park, and Robert H. Austin
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17290–17295. Published online 2006 November 7. doi: 10.1073/pnas.0607971103.
PMCID: PMC1635019
Geology
The potential rate of bed-load transport
Basil Gomez
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17170–17173. Published online 2006 November 6. doi: 10.1073/pnas.0608487103.
PMCID: PMC1859904
Physics
Electrostatic origin of the genome packing in viruses
Vladimir A. Belyi and M. Muthukumar
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17174–17178. Published online 2006 November 7. doi: 10.1073/pnas.0608311103.
PMCID: PMC1859905
Emergent magnetic moments produced by self-damage in plutonium
S. K. McCall, M. J. Fluss, B. W. Chung, M. W. McElfresh, D. D. Jackson, and G. F. Chapline
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17179–17183. Published online 2006 November 6. doi: 10.1073/pnas.0608552103.
PMCID: PMC1859906
Statistics
Genotypic predictors of human immunodeficiency virus type 1 drug resistance
Soo-Yon Rhee, Jonathan Taylor, Gauhar Wadhera, Asa Ben-Hur, Douglas L. Brutlag, and Robert W. Shafer
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17355–17360. Published online 2006 October 25. doi: 10.1073/pnas.0607274103.
PMCID: PMC1622926
Sustainability Science
Feasibility of cooling the Earth with a cloud of small spacecraft near the inner Lagrange point (L1)
Roger Angel
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17184–17189. Published online 2006 November 3. doi: 10.1073/pnas.0608163103.
PMCID: PMC1859907
Biological Sciences
Anthropology
Recent Southeast Asian domestication and Lapita dispersal of sacred male pseudohermaphroditic “tuskers” and hairless pigs of Vanuatu
J. Koji Lum, James K. McIntyre, Douglas L. Greger, Kirk W. Huffman, and Miguel G. Vilar
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17190–17195. Published online 2006 November 6. doi: 10.1073/pnas.0608220103.
PMCID: PMC1859908
Early modern humans from the Peştera Muierii, Baia de Fier, Romania
Andrei Soficaru, Adrian Doboş, and Erik Trinkaus
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17196–17201. Published online 2006 November 3. doi: 10.1073/pnas.0608443103.
PMCID: PMC1859909
Applied Biological Sciences
A critical role for IκB kinase α in the development of human and mouse squamous cell carcinomas
Bigang Liu, Eunmi Park, Feng Zhu, Tracie Bustos, Jinsong Liu, Jianjun Shen, Susan M. Fischer, and Yinling Hu
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17202–17207. Published online 2006 November 1. doi: 10.1073/pnas.0604481103.
PMCID: PMC1859910
Biochemistry
A methyldiazene (HNAn external file that holds a picture, illustration, etc., usually as some form of binary object. The name of referred object is cjs0808.jpgNAn external file that holds a picture, illustration, etc., usually as some form of binary object. The name of referred object is cjs0807.jpgCH3)-derived species bound to the nitrogenase active-site FeMo cofactor: Implications for mechanism
Brett M. Barney, Dmitriy Lukoyanov, Tran-Chin Yang, Dennis R. Dean, Brian M. Hoffman, and Lance C. Seefeldt
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17113–17118. Published online 2006 November 6. doi: 10.1073/pnas.0602130103.
PMCID: PMC1693872
From the Cover: Nitrogen Fixation Special Feature:
FeMo cofactor maturation on NifEN
Yilin Hu, Mary C. Corbett, Aaron W. Fay, Jerome A. Webber, Keith O. Hodgson, Britt Hedman, and Markus W. Ribbe
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17119–17124. Published online 2006 October 18. doi: 10.1073/pnas.0602647103.
PMCID: PMC1859895
From the Cover: Nitrogen Fixation Special Feature:
Nitrogenase Fe protein: A molybdate/homocitrate insertase
Yilin Hu, Mary C. Corbett, Aaron W. Fay, Jerome A. Webber, Keith O. Hodgson, Britt Hedman, and Markus W. Ribbe
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17125–17130. Published online 2006 October 24. doi: 10.1073/pnas.0602651103.
PMCID: PMC1859896
Flavodoxin hydroquinone reduces Azotobacter vinelandii Fe protein to the all-ferrous redox state with a S = 0 spin state
Thomas J. Lowery, Phillip E. Wilson, Bo Zhang, Jared Bunker, Roger G. Harrison, Andrew C. Nyborg, David Thiriot, and Gerald D. Watt
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17131–17136. Published online 2006 November 3. doi: 10.1073/pnas.0603223103.
PMCID: PMC1859897
From the Cover:
Structure of a heparin-dependent complex of Hedgehog and Ihog
Jason S. McLellan, Shenqin Yao, Xiaoyan Zheng, Brian V. Geisbrecht, Rodolfo Ghirlando, Philip A. Beachy, and Daniel J. Leahy
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17208–17213. Published online 2006 October 31. doi: 10.1073/pnas.0606738103.
PMCID: PMC1859911
Structural and biochemical studies of the C-terminal domain of mouse peptide-N-glycanase identify it as a mannose-binding module
Xiaoke Zhou, Gang Zhao, James J. Truglio, Liqun Wang, Guangtao Li, William J. Lennarz, and Hermann Schindelin
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17214–17219. Published online 2006 November 6. doi: 10.1073/pnas.0602954103.
PMCID: PMC1859912
A single mutation in the castor Δ9-18:0-desaturase changes reaction partitioning from desaturation to oxidase chemistry
Jodie E. Guy, Isabel A. Abreu, Martin Moche, Ylva Lindqvist, Edward Whittle, and John Shanklin
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17220–17224. Published online 2006 November 6. doi: 10.1073/pnas.0607165103.
PMCID: PMC1859913
Insights into transcription enhancer factor 1 (TEF-1) activity from the solution structure of the TEA domain
Asokan Anbanandam, Diana C. Albarado, Catherine T. Nguyen, Georg Halder, Xiaolian Gao, and Sudha Veeraraghavan
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17225–17230. Published online 2006 November 3. doi: 10.1073/pnas.0607171103.
PMCID: PMC1859914
Structure of DNA polymerase β with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features
Vinod K. Batra, David D. Shock, Rajendra Prasad, William A. Beard, Esther W. Hou, Lars C. Pedersen, Jane M. Sayer, Haruhiko Yagi, Subodh Kumar, Donald M. Jerina, and Samuel H. Wilson
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17231–17236. Published online 2006 November 1. doi: 10.1073/pnas.0605069103.
PMCID: PMC1630674
Structural basis for protein–protein interactions in the 14-3-3 protein family
Xiaowen Yang, Wen Hwa Lee, Frank Sobott, Evangelos Papagrigoriou, Carol V. Robinson, J. Günter Grossmann, Michael Sundström, Declan A. Doyle, and Jonathan M. Elkins
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17237–17242. Published online 2006 November 3. doi: 10.1073/pnas.0605779103.
PMCID: PMC1859916
Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic
Amanda L. McClerren, Lisa E. Cooper, Chao Quan, Paul M. Thomas, Neil L. Kelleher, and Wilfred A. van der Donk
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17243–17248. Published online 2006 November 3. doi: 10.1073/pnas.0606088103.
PMCID: PMC1859917
Biophysics
Adaptive wavefront correction in two-photon microscopy using coherence-gated wavefront sensing
Markus Rueckel, Julia A. Mack-Bucher, and Winfried Denk
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17137–17142. Published online 2006 November 6. doi: 10.1073/pnas.0604791103.
PMCID: PMC1634839
The color of rhodopsins at the ab initio multiconfigurational perturbation theory resolution
Pedro B. Coto, Angela Strambi, Nicolas Ferré, and Massimo Olivucci
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17154–17159. Published online 2006 November 7. doi: 10.1073/pnas.0604048103.
PMCID: PMC1859901
Electrostatic origin of the genome packing in viruses
Vladimir A. Belyi and M. Muthukumar
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17174–17178. Published online 2006 November 7. doi: 10.1073/pnas.0608311103.
PMCID: PMC1859905
The 10+4 microfibril structure of thin cartilage fibrils
David F. Holmes and Karl E. Kadler
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17249–17254. Published online 2006 November 6. doi: 10.1073/pnas.0608417103.
PMCID: PMC1859918
Cell Biology
Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels
Tobias B. Huber, Bernhard Schermer, Roman Ulrich Müller, Martin Höhne, Malte Bartram, Andrea Calixto, Henning Hagmann, Christian Reinhardt, Fabienne Koos, Karl Kunzelmann, Elena Shirokova, Dietmar Krautwurst, Christian Harteneck, Matias Simons, Hermann Pavenstädt, Dontscho Kerjaschki, Christoph Thiele, Gerd Walz, Martin Chalfie, and Thomas Benzing
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17079–17086. Published online 2006 November 1. doi: 10.1073/pnas.0607465103.
PMCID: PMC1859892
A three-dimensional model of myxobacterial fruiting-body formation
Olga Sozinova, Yi Jiang, Dale Kaiser, and Mark Alber
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17255–17259. Published online 2006 November 6. doi: 10.1073/pnas.0605555103.
PMCID: PMC1859919
VEGF, a prosurvival factor, acts in concert with TGF-β1 to induce endothelial cell apoptosis
Giovanni Ferrari, Giuseppe Pintucci, Graziano Seghezzi, Kevin Hyman, Aubrey C. Galloway, and Paolo Mignatti
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17260–17265. Published online 2006 November 6. doi: 10.1073/pnas.0605556103.
PMCID: PMC1859920
Self-renewal of embryonic stem cells by a small molecule
Shuibing Chen, Jeong Tae Do, Qisheng Zhang, Shuyuan Yao, Feng Yan, Eric C. Peters, Hans R. Schöler, Peter G. Schultz, and Sheng Ding
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17266–17271. Published online 2006 November 6. doi: 10.1073/pnas.0608156103.
PMCID: PMC1859921
AMP-activated protein kinase regulates the assembly of epithelial tight junctions
Li Zhang, Ji Li, Lawrence H. Young, and Michael J. Caplan
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17272–17277. Published online 2006 November 6. doi: 10.1073/pnas.0608531103.
PMCID: PMC1859922
Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA
Keiko Horiuchi, Michihisa Umetani, Takashi Minami, Hiroto Okayama, Shinji Takada, Masayuki Yamamoto, Hiroyuki Aburatani, Patrick C. Reid, David E. Housman, Takao Hamakubo, and Tatsuhiko Kodama
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17278–17283. Published online 2006 November 6. doi: 10.1073/pnas.0608357103.
PMCID: PMC1634838
Developmental Biology
A subunit of the mediator complex regulates vertebrate neuronal development
Xiaoqun Wang, Nan Yang, Etsuko Uno, Robert G. Roeder, and Su Guo
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17284–17289. Published online 2006 November 6. doi: 10.1073/pnas.0605414103.
PMCID: PMC1859923
Evolution
Bacterial metapopulations in nanofabricated landscapes
Juan E. Keymer, Peter Galajda, Cecilia Muldoon, Sungsu Park, and Robert H. Austin
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17290–17295. Published online 2006 November 7. doi: 10.1073/pnas.0607971103.
PMCID: PMC1635019
A proboscidean from the late Oligocene of Eritrea, a “missing link” between early Elephantiformes and Elephantimorpha, and biogeographic implications
Jeheskel Shoshani, Robert C. Walter, Michael Abraha, Seife Berhe, Pascal Tassy, William J. Sanders, Gary H. Marchant, Yosief Libsekal, Tesfalidet Ghirmai, and Dietmar Zinner
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17296–17301. Published online 2006 November 3. doi: 10.1073/pnas.0603689103.
PMCID: PMC1859925
Rapidly evolving zona pellucida domain proteins are a major component of the vitelline envelope of abalone eggs
Jan E. Aagaard, Xianhua Yi, Michael J. MacCoss, and Willie J. Swanson
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17302–17307. Published online 2006 November 3. doi: 10.1073/pnas.0603125103.
PMCID: PMC1859926
Cognitive cladistics and cultural override in Hominid spatial cognition
Daniel B. M. Haun, Christian J. Rapold, Josep Call, Gabriele Janzen, and Stephen C. Levinson
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17568–17573. Published online 2006 November 1. doi: 10.1073/pnas.0607999103.
PMCID: PMC1859970
Genetics
From the Cover:
Germ-line epigenetic modification of the murine Avy allele by nutritional supplementation
Jennifer E. Cropley, Catherine M. Suter, Kenneth B. Beckman, and David I. K. Martin
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17308–17312. Published online 2006 November 13. doi: 10.1073/pnas.0607090103.
PMCID: PMC1838538
Veela defines a molecular link between Cryptochrome and Timeless in the light-input pathway to Drosophila's circadian clock
Nicolai Peschel, Shobi Veleri, and Ralf Stanewsky
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17313–17318. Published online 2006 October 26. doi: 10.1073/pnas.0606675103.
PMCID: PMC1859927
Multiple pathways of selected gene amplification during adaptive mutation
Elisabeth Kugelberg, Eric Kofoid, Andrew B. Reams, Dan I. Andersson, and John R. Roth
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17319–17324. Published online 2006 November 2. doi: 10.1073/pnas.0608309103.
PMCID: PMC1633709
DNA nucleotide excision repair-dependent signaling to checkpoint activation
Federica Marini, Tiziana Nardo, Michele Giannattasio, Mario Minuzzo, Miria Stefanini, Paolo Plevani, and Marco Muzi Falconi
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17325–17330. Published online 2006 November 6. doi: 10.1073/pnas.0605446103.
PMCID: PMC1859929
Telomere-mediated chromosomal truncation in maize
Weichang Yu, Jonathan C. Lamb, Fangpu Han, and James A. Birchler
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17331–17336. Published online 2006 November 3. doi: 10.1073/pnas.0605750103.
PMCID: PMC1859930
Small dsRNAs induce transcriptional activation in human cells
Long-Cheng Li, Steven T. Okino, Hong Zhao, Deepa Pookot, Robert F. Place, Shinji Urakami, Hideki Enokida, and Rajvir Dahiya
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17337–17342. Published online 2006 November 3. doi: 10.1073/pnas.0607015103.
PMCID: PMC1859931
Immunology
Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells
Ayuko Sato, Melissa M. Linehan, and Akiko Iwasaki
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17343–17348. Published online 2006 November 3. doi: 10.1073/pnas.0605102103.
PMCID: PMC1859932
Hexim1 sequesters positive transcription elongation factor b from the class II transactivator on MHC class II promoters
Jiri Kohoutek, Dalibor Blazek, and B. Matija Peterlin
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17349–17354. Published online 2006 November 6. doi: 10.1073/pnas.0603079103.
PMCID: PMC1859933
Medical Sciences
Genotypic predictors of human immunodeficiency virus type 1 drug resistance
Soo-Yon Rhee, Jonathan Taylor, Gauhar Wadhera, Asa Ben-Hur, Douglas L. Brutlag, and Robert W. Shafer
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17355–17360. Published online 2006 October 25. doi: 10.1073/pnas.0607274103.
PMCID: PMC1622926
uPAR and HER-2 gene status in individual breast cancer cells from blood and tissues
Songdong Meng, Debu Tripathy, Sanjay Shete, Raheela Ashfaq, Hossein Saboorian, Barbara Haley, Eugene Frenkel, David Euhus, Marilyn Leitch, Cynthia Osborne, Edward Clifford, Steve Perkins, Peter Beitsch, Amanullah Khan, Larry Morrison, Dorothee Herlyn, Leon W. M. M. Terstappen, Nancy Lane, Jianqiang Wang, and Jonathan Uhr
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17361–17365. Published online 2006 November 1. doi: 10.1073/pnas.0608113103.
PMCID: PMC1838539
Apoptosis in retinal degeneration involves cross-talk between apoptosis-inducing factor (AIF) and caspase-12 and is blocked by calpain inhibitors
Daniela Sanges, Antonella Comitato, Roberta Tammaro, and Valeria Marigo
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17366–17371. Published online 2006 November 6. doi: 10.1073/pnas.0606276103.
PMCID: PMC1859935
Gene transfer in humans using a conditionally replicating lentiviral vector
Bruce L. Levine, Laurent M. Humeau, Jean Boyer, Rob-Roy MacGregor, Tessio Rebello, Xiaobin Lu, Gwendolyn K. Binder, Vladimir Slepushkin, Franck Lemiale, John R. Mascola, Frederic D. Bushman, Boro Dropulic, and Carl H. June
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17372–17377. Published online 2006 November 7. doi: 10.1073/pnas.0608138103.
PMCID: PMC1635018
A pivotal role for endogenous TGF-β-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway
Min Xie, Dou Zhang, Jason R. B. Dyck, Yi Li, Hui Zhang, Masae Morishima, Douglas L. Mann, George E. Taffet, Antonio Baldini, Dirar S. Khoury, and Michael D. Schneider
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17378–17383. Published online 2006 November 3. doi: 10.1073/pnas.0604708103.
PMCID: PMC1859937
Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer
Babak Oskouian, Prathap Sooriyakumaran, Alexander D. Borowsky, Angelina Crans, Lisa Dillard-Telm, Yuen Yee Tam, Padmavathi Bandhuvula, and Julie D. Saba
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17384–17389. Published online 2006 November 7. doi: 10.1073/pnas.0600050103.
PMCID: PMC1859938
Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc
Seok-Geun Lee, Zao-Zhong Su, Luni Emdad, Devanand Sarkar, and Paul B. Fisher
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17390–17395. Published online 2006 November 6. doi: 10.1073/pnas.0608386103.
PMCID: PMC1859939
Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models
Zhijun Du, Katrina Podsypanina, Shixia Huang, Amanda McGrath, Michael J. Toneff, Ekaterina Bogoslovskaia, Xiaomei Zhang, Ricardo C. Moraes, Michele Fluck, D. Craig Allred, Michael T. Lewis, Harold E. Varmus, and Yi Li
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17396–17401. Published online 2006 November 7. doi: 10.1073/pnas.0608607103.
PMCID: PMC1635021
Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target
S. Horvath, B. Zhang, M. Carlson, K. V. Lu, S. Zhu, R. M. Felciano, M. F. Laurance, W. Zhao, S. Qi, Z. Chen, Y. Lee, A. C. Scheck, L. M. Liau, H. Wu, D. H. Geschwind, P. G. Febbo, H. I. Kornblum, T. F. Cloughesy, S. F. Nelson, and P. S. Mischel
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17402–17407. Published online 2006 November 7. doi: 10.1073/pnas.0608396103.
PMCID: PMC1635024
Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90
Jens R. Sydor, Emmanuel Normant, Christine S. Pien, James R. Porter, Jie Ge, Louis Grenier, Roger H. Pak, Janid A. Ali, Marlene S. Dembski, Jebecka Hudak, Jon Patterson, Courtney Penders, Melissa Pink, Margaret A. Read, Jim Sang, Caroline Woodward, Yilong Zhang, David S. Grayzel, Jim Wright, John A. Barrett, Vito J. Palombella, Julian Adams, and Jeffrey K. Tong
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17408–17413. Published online 2006 November 7. doi: 10.1073/pnas.0608372103.
PMCID: PMC1635022
Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases
Christine Beeton, Heike Wulff, Nathan E. Standifer, Philippe Azam, Katherine M. Mullen, Michael W. Pennington, Aaron Kolski-Andreaco, Eric Wei, Alexandra Grino, Debra R. Counts, Ping H. Wang, Christine J. LeeHealey, Brian S. Andrews, Ananthakrishnan Sankaranarayanan, Daniel Homerick, Werner W. Roeck, Jamshid Tehranzadeh, Kimber L. Stanhope, Pavel Zimin, Peter J. Havel, Stephen Griffey, Hans-Guenther Knaus, Gerald T. Nepom, George A. Gutman, Peter A. Calabresi, and K. George Chandy
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17414–17419. Published online 2006 November 6. doi: 10.1073/pnas.0605136103.
PMCID: PMC1859943
Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2A receptor
Jeffrey P. Walterscheid, Dat X. Nghiem, Nasser Kazimi, Leta K. Nutt, David J. McConkey, Mary Norval, and Stephen E. Ullrich
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17420–17425. Published online 2006 November 3. doi: 10.1073/pnas.0603119103.
PMCID: PMC1859944
Mullerian Inhibiting Substance enhances subclinical doses of chemotherapeutic agents to inhibit human and mouse ovarian cancer
Rafael Pieretti-Vanmarcke, Patricia K. Donahoe, Lisa A. Pearsall, Daniela M. Dinulescu, Denise C. Connolly, Elkan F. Halpern, Michael V. Seiden, and David T. MacLaughlin
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17426–17431. Published online 2006 November 6. doi: 10.1073/pnas.0607959103.
PMCID: PMC1859945
An essential role of NF-κB in the “tumor-like” phenotype of arthritic synoviocytes
Xiangli Li and Sergei S. Makarov
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17432–17437. Published online 2006 November 6. doi: 10.1073/pnas.0607939103.
PMCID: PMC1859946
Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice
Ryang Hwa Lee, Min Jeong Seo, Roxanne L. Reger, Jeffrey L. Spees, Andrey A. Pulin, Scott D. Olson, and Darwin J. Prockop
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17438–17443. Published online 2006 November 6. doi: 10.1073/pnas.0608249103.
PMCID: PMC1634835
Correlation between β cell mass and glycemic control in type 1 diabetic recipients of islet cell graft
Bart Keymeulen, Pieter Gillard, Chantal Mathieu, Babak Movahedi, Geert Maleux, Georges Delvaux, Dirk Ysebaert, Bart Roep, Evy Vandemeulebroucke, Miriam Marichal, Peter In 't Veld, Marika Bogdani, Christel Hendrieckx, Frans Gorus, Zhidong Ling, Jon van Rood, and Daniel Pipeleers
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17444–17449. Published online 2006 November 7. doi: 10.1073/pnas.0608141103.
PMCID: PMC1859948
Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue
Valentina Sukonina, Aivar Lookene, Thomas Olivecrona, and Gunilla Olivecrona
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17450–17455. Published online 2006 November 6. doi: 10.1073/pnas.0604026103.
PMCID: PMC1859949
Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid
P. T. Johnson, K. E. Betts, M. J. Radeke, G. S. Hageman, D. H. Anderson, and L. V. Johnson
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17456–17461. Published online 2006 November 1. doi: 10.1073/pnas.0606234103.
PMCID: PMC1859950
Microbiology
Combinatorial biosynthesis of novel antibiotics related to daptomycin
Kien T. Nguyen, Daniel Ritz, Jian-Qiao Gu, Dylan Alexander, Min Chu, Vivian Miao, Paul Brian, and Richard H. Baltz
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17462–17467. Published online 2006 November 7. doi: 10.1073/pnas.0608589103.
PMCID: PMC1859951
Quinone sensing by the circadian input kinase of the cyanobacterial circadian clock
Natalia B. Ivleva, Tiyu Gao, Andy C. LiWang, and Susan S. Golden
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17468–17473. Published online 2006 November 6. doi: 10.1073/pnas.0606639103.
PMCID: PMC1859952
An escort mechanism for cycling of export chaperones during flagellum assembly
Lewis D. B. Evans, Graham P. Stafford, Sangita Ahmed, Gillian M. Fraser, and Colin Hughes
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17474–17479. Published online 2006 November 6. doi: 10.1073/pnas.0605197103.
PMCID: PMC1859953
Systems approach to refining genome annotation
Jennifer L. Reed, Trina R. Patel, Keri H. Chen, Andrew R. Joyce, Margaret K. Applebee, Christopher D. Herring, Olivia T. Bui, Eric M. Knight, Stephen S. Fong, and Bernhard O. Palsson
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17480–17484. Published online 2006 November 6. doi: 10.1073/pnas.0603364103.
PMCID: PMC1859954
Biogenesis of actin-like bacterial cytoskeletal filaments destined for positioning prokaryotic magnetic organelles
Nathalie Pradel, Claire-Lise Santini, Alain Bernadac, Yoshihiro Fukumori, and Long-Fei Wu
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17485–17489. Published online 2006 November 3. doi: 10.1073/pnas.0603760103.
PMCID: PMC1859955
Neuroscience
Unequal representation of cardinal vs. oblique orientations in the middle temporal visual area
Xiangmin Xu, Christine E. Collins, Ilya Khaytin, Jon H. Kaas, and Vivien A. Casagrande
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17490–17495. Published online 2006 November 6. doi: 10.1073/pnas.0608502103.
PMCID: PMC1859956
The Drosophila radish gene encodes a protein required for anesthesia-resistant memory
Elisabeth Folkers, Scott Waddell, and William G. Quinn
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17496–17500. Published online 2006 November 6. doi: 10.1073/pnas.0608377103.
PMCID: PMC1634833
Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus
Michael D. Saxe, Fortunato Battaglia, Jing-Wen Wang, Gael Malleret, Denis J. David, James E. Monckton, A. Denise R. Garcia, Michael V. Sofroniew, Eric R. Kandel, Luca Santarelli, René Hen, and Michael R. Drew
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17501–17506. Published online 2006 November 6. doi: 10.1073/pnas.0607207103.
PMCID: PMC1859958
Local field potential reflects perceptual suppression in monkey visual cortex
Melanie Wilke, Nikos K. Logothetis, and David A. Leopold
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17507–17512. Published online 2006 November 6. doi: 10.1073/pnas.0604673103.
PMCID: PMC1859959
Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injury
Ulrika Wilhelmsson, Eric A. Bushong, Diana L. Price, Benjamin L. Smarr, Van Phung, Masako Terada, Mark H. Ellisman, and Milos Pekny
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17513–17518. Published online 2006 November 7. doi: 10.1073/pnas.0602841103.
PMCID: PMC1859960
Learning and memory associated with aggression in Drosophila melanogaster
Alexandra Yurkovic, Oulu Wang, Alo C. Basu, and Edward A. Kravitz
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17519–17524. Published online 2006 November 6. doi: 10.1073/pnas.0608211103.
PMCID: PMC1634832
Structural and functional MRI reveals multiple retinal layers
Haiying Cheng, Govind Nair, Tiffany A. Walker, Moon K. Kim, Machelle T. Pardue, Peter M. Thulé, Darin E. Olson, and Timothy Q. Duong
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17525–17530. Published online 2006 November 6. doi: 10.1073/pnas.0605790103.
PMCID: PMC1859962
Pharmacology
Carbamylated erythropoietin ameliorates the metabolic stress induced in vivo by severe chronic hypoxia
Monica Fantacci, Paola Bianciardi, Anna Caretti, Thomas R. Coleman, Anthony Cerami, Michael Brines, and Michele Samaja
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17531–17536. Published online 2006 November 7. doi: 10.1073/pnas.0608814103.
PMCID: PMC1859963
Identification of the α2-δ-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin
Mark J. Field, Peter J. Cox, Emma Stott, Heather Melrose, James Offord, Ti-Zhi Su, Steve Bramwell, Laura Corradini, Steven England, Joanna Winks, Ross A. Kinloch, Jan Hendrich, Annette C. Dolphin, Tony Webb, and Dic Williams
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17537–17542. Published online 2006 November 6. doi: 10.1073/pnas.0409066103.
PMCID: PMC1859964
Physiology
An exceptionally fast actomyosin reaction powers insect flight muscle
Douglas M. Swank, Vivek K. Vishnudas, and David W. Maughan
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17543–17547. Published online 2006 November 3. doi: 10.1073/pnas.0604972103.
PMCID: PMC1859965
SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes
Alex J. Fay, Xiang Qian, Yuh Nung Jan, and Lily Yeh Jan
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17548–17553. Published online 2006 November 3. doi: 10.1073/pnas.0607914103.
PMCID: PMC1634413
Plant Biology
The protective role of silicon in the Arabidopsis–powdery mildew pathosystem
François Fauteux, Florian Chain, François Belzile, James G. Menzies, and Richard R. Bélanger
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17554–17559. Published online 2006 November 2. doi: 10.1073/pnas.0606330103.
PMCID: PMC1859967
Population Biology
Source reduction of mosquito larval habitats has unexpected consequences on malaria transmission
Weidong Gu, James L. Regens, John C. Beier, and Robert J. Novak
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17560–17563. Published online 2006 November 3. doi: 10.1073/pnas.0608452103.
PMCID: PMC1634411
Psychology
Evidence for large long-term memory capacities in baboons and pigeons and its implications for learning and the evolution of cognition
Joël Fagot and Robert G. Cook
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17564–17567. Published online 2006 November 6. doi: 10.1073/pnas.0605184103.
PMCID: PMC1634836
Social Sciences
Psychology
Cognitive cladistics and cultural override in Hominid spatial cognition
Daniel B. M. Haun, Christian J. Rapold, Josep Call, Gabriele Janzen, and Stephen C. Levinson
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17568–17573. Published online 2006 November 1. doi: 10.1073/pnas.0607999103.
PMCID: PMC1859970
Sustainability Science
Returning forests analyzed with the forest identity
Pekka E. Kauppi, Jesse H. Ausubel, Jingyun Fang, Alexander S. Mather, Roger A. Sedjo, and Paul E. Waggoner
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17574–17579. Published online 2006 November 13. doi: 10.1073/pnas.0608343103.
PMCID: PMC1635979
Cell Biology
Correction for Ceppi et al., Two tail-anchored protein variants, differing in transmembrane domain length and intracellular sorting, interact differently with lipids
Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17580. Published online 2006 November 6. doi: 10.1073/pnas.0608601103.
PMCID: PMC1859972
Corrects: Paolo Ceppi, et al. Two tail-anchored protein variants, differing in transmembrane domain length and intracellular sorting, interact differently with lipids. Proc Natl Acad Sci U S A. 2005 November 8; 102(45): 16269–16274.
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