| | This journal provides immediate access to some articles. Invited Review Rabs and their effectors: Achieving specificity in membrane traffic Bianka L. Grosshans, Darinel Ortiz, and Peter Novick PMCID: PMC1567661 This Week in PNAS Proc Natl Acad Sci U S A. 2006 August 8; 103(32): 11815–11816. doi: 10.1073/iti3206103.PMCID: PMC1567659 Commentaries Peeking into living eukaryotic cells with high-resolution NMR Lisa M. Charlton and Gary J. Pielak PMCID: PMC1567660 Two-component signaling provides the major output from the cyanobacterial circadian clock C. Robertson McClung PMCID: PMC1832255 Physical Sciences Applied Mathematics Singular value decomposition of genome-scale mRNA lengths distribution reveals asymmetry in RNA gel electrophoresis band broadening Orly Alter and Gene H. Golub PMCID: PMC1524674 Structural kinetic modeling of metabolic networks Ralf Steuer, Thilo Gross, Joachim Selbig, and Bernd Blasius PMCID: PMC1524928 Applied Physical Sciences Beyond the metal-insulator transition in polymer electrolyte gated polymer field-effect transistors Anoop S. Dhoot, Jonathan D. Yuen, Martin Heeney, Iain McCulloch, Daniel Moses, and Alan J. Heeger PMCID: PMC1567663 Chemistry From the Cover:
Aptamers evolved from live cells as effective molecular probes for cancer study Dihua Shangguan, Ying Li, Zhiwen Tang, Zehui Charles Cao, Hui William Chen, Prabodhika Mallikaratchy, Kwame Sefah, Chaoyong James Yang, and Weihong Tan PMCID: PMC1567664 Multiple-basin energy landscapes for large-amplitude conformational motions of proteins: Structure-based molecular dynamics simulations Kei-ichi Okazaki, Nobuyasu Koga, Shoji Takada, Jose N. Onuchic, and Peter G. Wolynes PMCID: PMC1567665 Olefin metathesis and quadruple hydrogen bonding: A powerful combination in multistep supramolecular synthesis Oren A. Scherman, G. B. W. L. Ligthart, Haruki Ohkawa, Rint P. Sijbesma, and E. W. Meijer PMCID: PMC1832257 Biological Sciences Agricultural Sciences A viral resistance gene from common bean functions across plant families and is up-regulated in a non-virus-specific manner Young-Su Seo, Maria R. Rojas, Jung-Youn Lee, Sang-Won Lee, Jong-Seong Jeon, Pamela Ronald, William J. Lucas, and Robert L. Gilbertson PMCID: PMC1567666 Applied Biological Sciences Age-dependent accumulation of recombinant cells in the mouse pancreas revealed by in situ fluorescence imaging Dominika M. Wiktor-Brown, Carrie A. Hendricks, Werner Olipitz, and Bevin P. Engelward PMCID: PMC1567667 Biochemistry From the Cover:
Aptamers evolved from live cells as effective molecular probes for cancer study Dihua Shangguan, Ying Li, Zhiwen Tang, Zehui Charles Cao, Hui William Chen, Prabodhika Mallikaratchy, Kwame Sefah, Chaoyong James Yang, and Weihong Tan PMCID: PMC1567664 Structural kinetic modeling of metabolic networks Ralf Steuer, Thilo Gross, Joachim Selbig, and Bernd Blasius PMCID: PMC1524928 A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly Matthew S. O'Connor, Amin Safari, Huawei Xin, Dan Liu, and Zhou Songyang PMCID: PMC1567669 A genomewide screen for components of the RNAi pathway in Drosophila cultured cells Silke Dorner, Lawrence Lum, Michelle Kim, Renato Paro, Philip A. Beachy, and Rachel Green PMCID: PMC1525048 Structure of FliM provides insight into assembly of the switch complex in the bacterial flagella motor Sang-Youn Park, Bryan Lowder, Alexandrine M. Bilwes, David F. Blair, and Brian R. Crane PMCID: PMC1567671 Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease family Stefano Ricagno, Marie-Pierre Egloff, Rachel Ulferts, Bruno Coutard, Didier Nurizzo, Valérie Campanacci, Christian Cambillau, John Ziebuhr, and Bruno Canard PMCID: PMC2131687 Structure of the nuclear exosome component Rrp6p reveals an interplay between the active site and the HRDC domain Søren F. Midtgaard, Jannie Assenholt, Anette Thyssen Jonstrup, Lan B. Van, Torben Heick Jensen, and Ditlev E. Brodersen PMCID: PMC2131688 Biophysics Multiple-basin energy landscapes for large-amplitude conformational motions of proteins: Structure-based molecular dynamics simulations Kei-ichi Okazaki, Nobuyasu Koga, Shoji Takada, Jose N. Onuchic, and Peter G. Wolynes PMCID: PMC1567665 From the Cover:
Quantitative NMR analysis of the protein G B1 domain in Xenopus laevis egg extracts and intact oocytes Philipp Selenko, Zach Serber, Bedrick Gadea, Joan Ruderman, and Gerhard Wagner PMCID: PMC1523310 Complementarity of ensemble and single-molecule measures of protein motion: A relaxation dispersion NMR study of an enzyme complex Pramodh Vallurupalli and Lewis E. Kay PMCID: PMC1567672 Ensemble molecular dynamics yields submillisecond kinetics and intermediates of membrane fusion Peter M. Kasson, Nicholas W. Kelley, Nina Singhal, Marija Vrljic, Axel T. Brunger, and Vijay S. Pande PMCID: PMC1567673 Nanostructure of fibrillin-1 reveals compact conformation of EGF arrays and mechanism for extensibility Clair Baldock, Veronique Siegler, Daniel V. Bax, Stuart A. Cain, Kieran T. Mellody, Andrew Marson, J. Louise Haston, Richard Berry, Ming-Chuan Wang, J. Günter Grossmann, Manfred Roessle, Cay M. Kielty, and Tim J. Wess PMCID: PMC1567674 Cell Biology The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis Akira Hayakawa, Deborah Leonard, Stephanie Murphy, Susan Hayes, Martha Soto, Kevin Fogarty, Clive Standley, Karl Bellve, David Lambright, Craig Mello, and Silvia Corvera PMCID: PMC1567675 Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2μ–cargo complexes Michael Krauss, Viktoria Kukhtina, Arndt Pechstein, and Volker Haucke PMCID: PMC1567676 Unique players in the BMP pathway: Small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling Marie Knockaert, Gopal Sapkota, Claudio Alarcón, Joan Massagué, and Ali H. Brivanlou PMCID: PMC1567677 Nuclear targeting of Akt antagonizes aspects of cardiomyocyte hypertrophy Yasuyuki Tsujita, John Muraski, Isao Shiraishi, Takahiro Kato, Jan Kajstura, Piero Anversa, and Mark A. Sussman PMCID: PMC1567678 Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer Michele E. Forsythe, Dona C. Love, Brooke D. Lazarus, Eun Ju Kim, William A. Prinz, Gilbert Ashwell, Michael W. Krause, and John A. Hanover PMCID: PMC1567679 Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence Kim B. Jensen and Fiona M. Watt PMCID: PMC1567680 Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1) Jiabin Tang, Raymond L. Erikson, and Xiaoqi Liu PMCID: PMC1567681 Developmental Biology Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling Kristen Tenney, Mark Gerber, Anne Ilvarsonn, Jessica Schneider, Maria Gause, Dale Dorsett, Joel C. Eissenberg, and Ali Shilatifard PMCID: PMC1567682 Transcriptional regulation by Modulo integrates meiosis and spermatid differentiation in male germ line Lyudmila M. Mikhaylova, Alexander M. Boutanaev, and Dmitry I. Nurminsky PMCID: PMC1567683 Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects Daiji Kiyozumi, Nagisa Sugimoto, and Kiyotoshi Sekiguchi PMCID: PMC1567684 The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis Fei Gao, Sourindra Maiti, Nargis Alam, Zhen Zhang, Jian Min Deng, Richard R. Behringer, Charlotte Lécureuil, Florian Guillou, and Vicki Huff PMCID: PMC1567685 Notch/Delta signaling constrains reengineering of pro-T cells by PU.1 Christopher B. Franco, Deirdre D. Scripture-Adams, Irina Proekt, Tom Taghon, Angela H. Weiss, Mary A. Yui, Stephanie L. Adams, Rochelle A. Diamond, and Ellen V. Rothenberg PMCID: PMC1567686 The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman Takeshi Akasaka, Susan Klinedinst, Karen Ocorr, Erika L. Bustamante, Seung K. Kim, and Rolf Bodmer PMCID: PMC1567687 Evolution Stress and the suppression of subordinate reproduction in cooperatively breeding meerkats Andrew J. Young, Anne A. Carlson, Steven L. Monfort, Andrew F. Russell, Nigel C. Bennett, and Tim Clutton-Brock PMCID: PMC1567688 Red blood with blue-blood ancestry: Intriguing structure of a snail hemoglobin Bernhard Lieb, Konstantina Dimitrova, Hio-Sun Kang, Sabrina Braun, Wolfgang Gebauer, Andreas Martin, Ben Hanelt, Steven A. Saenz, Coen M. Adema, and Jürgen Markl PMCID: PMC1567689 An apparent reversal in floral symmetry in the legume Cadia is a homeotic transformation Hélène L. Citerne, R. Toby Pennington, and Quentin C. B. Cronk PMCID: PMC1567690 Functional development of Src tyrosine kinases during evolution from a unicellular ancestor to multicellular animals Yuko Segawa, Hiroshi Suga, Naoyuki Iwabe, Chitose Oneyama, Tsuyoshi Akagi, Takashi Miyata, and Masato Okada PMCID: PMC1567691 Genetics Singular value decomposition of genome-scale mRNA lengths distribution reveals asymmetry in RNA gel electrophoresis band broadening Orly Alter and Gene H. Golub PMCID: PMC1524674 Hotspots of transcription factor colocalization in the genome of Drosophila melanogaster Celine Moorman, Ling V. Sun, Junbai Wang, Elzo de Wit, Wendy Talhout, Lucas D. Ward, Frauke Greil, Xiang-Jun Lu, Kevin P. White, Harmen J. Bussemaker, and Bas van Steensel PMCID: PMC1567692 Importance of dosage standardization for interpreting transcriptomal signature profiles: Evidence from studies of xenoestrogens Toshi Shioda, Jessica Chesnes, Kathryn R. Coser, Lihua Zou, Jingyung Hur, Kathleen L. Dean, Carlos Sonnenschein, Ana M. Soto, and Kurt J. Isselbacher PMCID: PMC1525050 The putatively functional Mkrn1-p1 pseudogene is neither expressed nor imprinted, nor does it regulate its source gene in trans Todd A. Gray, Alison Wilson, Patrick J. Fortin, and Robert D. Nicholls PMCID: PMC1567693 Identifying transcription factor functions and targets by phenotypic activation Gordon Chua, Quaid D. Morris, Richelle Sopko, Mark D. Robinson, Owen Ryan, Esther T. Chan, Brendan J. Frey, Brenda J. Andrews, Charles Boone, and Timothy R. Hughes PMCID: PMC1567694 Transcriptional inactivation of a regulatory site for replication of Vibrio cholerae chromosome II Tatiana Venkova-Canova, Preeti Srivastava, and Dhruba K. Chattoraj PMCID: PMC1567695 Immunology Reconstitution of paired T cell receptor α- and β-chains from microdissected single cells of human inflammatory tissues Sabine Seitz, Christian K. Schneider, Joachim Malotka, Xiao Nong, Andrew G. Engel, Hartmut Wekerle, Reinhard Hohlfeld, and Klaus Dornmair PMCID: PMC1567696 CD8 T cell competition for dendritic cells in vivo is an early event in activation Richard A. Willis, John W. Kappler, and Philippa C. Marrack PMCID: PMC1524925 Monitoring the T cell response to genital tract infection Nadia R. Roan, Todd M. Gierahn, Darren E. Higgins, and Michael N. Starnbach PMCID: PMC1567698 ITK and IL-15 support two distinct subsets of CD8+ T cells Sigrid Dubois, Thomas A. Waldmann, and Jürgen R. Müller PMCID: PMC1567699 Involvement of Rad18 in somatic hypermutation Jürgen Bachl, Isin Ertongur, and Berit Jungnickel PMCID: PMC1567700 Identification of IgF, a hinge-region-containing Ig class, and IgD in Xenopus tropicalis Yaofeng Zhao, Qiang Pan-Hammarström, Shuyang Yu, Nancy Wertz, Xiaofeng Zhang, Ning Li, John E. Butler, and Lennart Hammarström PMCID: PMC1567701 Medical Sciences Phosphoinositide 3-kinase regulatory subunit p85α suppresses insulin action via positive regulation of PTEN Cullen M. Taniguchi, Thien T. Tran, Tatsuya Kondo, Ji Luo, Kohjiro Ueki, Lewis C. Cantley, and C. Ronald Kahn PMCID: PMC1524929 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis Seung-Jae Myung, Ronald M. Rerko, Min Yan, Petra Platzer, Kishore Guda, Angela Dotson, Earl Lawrence, Andrew J. Dannenberg, Alysia Kern Lovgren, Guangbin Luo, Theresa P. Pretlow, Robert A. Newman, Joseph Willis, Dawn Dawson, and Sanford D. Markowitz PMCID: PMC1567703 The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: A magnetoencephalographic study Otto Tschritter, Hubert Preissl, Anita M. Hennige, Michael Stumvoll, Katarina Porubska, Rebekka Frost, Hannah Marx, Benjamin Klösel, Werner Lutzenberger, Niels Birbaumer, Hans-Ulrich Häring, and Andreas Fritsche PMCID: PMC1567704 Microbiology From the Cover:
A KaiC-associating SasA–RpaA two-component regulatory system as a major circadian timing mediator in cyanobacteria Naoki Takai, Masato Nakajima, Tokitaka Oyama, Ryotaku Kito, Chieko Sugita, Mamoru Sugita, Takao Kondo, and Hideo Iwasaki PMCID: PMC1832256 Microbial diversity in the deep sea and the underexplored “rare biosphere” Mitchell L. Sogin, Hilary G. Morrison, Julie A. Huber, David Mark Welch, Susan M. Huse, Phillip R. Neal, Jesus M. Arrieta, and Gerhard J. Herndl PMCID: PMC1524930 Lack of transmission of H5N1 avian–human reassortant influenza viruses in a ferret model Taronna R. Maines, Li-Mei Chen, Yumiko Matsuoka, Hualan Chen, Thomas Rowe, Juan Ortin, Ana Falcón, Nguyen Tran Hien, Le Quynh Mai, Endang R. Sedyaningsih, Syahrial Harun, Terrence M. Tumpey, Ruben O. Donis, Nancy J. Cox, Kanta Subbarao, and Jacqueline M. Katz PMCID: PMC1567706 Neuroscience AMPA receptors regulate experience-dependent dendritic arbor growth in vivo Kurt Haas, Jianli Li, and Hollis T. Cline PMCID: PMC1525049 The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice Du-Chu Wu, Diane Bérangère Ré, Makiko Nagai, Harry Ischiropoulos, and Serge Przedborski PMCID: PMC1562547 Cellular scaling rules for rodent brains Suzana Herculano-Houzel, Bruno Mota, and Roberto Lent PMCID: PMC1567708 Theoretical model of temperature regulation in the brain during changes in functional activity Alexander L. Sukstanskii and Dmitriy A. Yablonskiy PMCID: PMC1567709 The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker Michihiro Mieda, S. Clay Williams, James A. Richardson, Kohichi Tanaka, and Masashi Yanagisawa PMCID: PMC1567710 Dendrites of rod bipolar cells sprout in normal aging retina Lauren C. Liets, Kasra Eliasieh, Deborah A. van der List, and Leo M. Chalupa PMCID: PMC1524926 From the Cover:
Indispensability of the glutamate transporters GLAST and GLT1 to brain development Toshiko R. Matsugami, Kentaro Tanemura, Michihiro Mieda, Reiko Nakatomi, Keiko Yamada, Takashi Kondo, Masaharu Ogawa, Kunihiko Obata, Masahiko Watanabe, Tsutomu Hashikawa, and Kohichi Tanaka PMCID: PMC1524927 Pharmacology Clonogenic multipotent stem cells in human adipose tissue differentiate into functional smooth muscle cells Larissa V. Rodríguez, Zeni Alfonso, Rong Zhang, Joanne Leung, Benjamin Wu, and Louis J. Ignarro PMCID: PMC1567713 Physiology Genome-wide RNAi screening identifies protein damage as a regulator of osmoprotective gene expression Todd Lamitina, Chunyi George Huang, and Kevin Strange PMCID: PMC1567714 Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy Prince J. Kannankeril, Brett M. Mitchell, Sanjeewa A. Goonasekera, Mihail G. Chelu, Wei Zhang, Subeena Sood, Debra L. Kearney, Cristina I. Danila, Mariella De Biasi, Xander H. T. Wehrens, Robia G. Pautler, Dan M. Roden, George E. Taffet, Robert T. Dirksen, Mark E. Anderson, and Susan L. Hamilton PMCID: PMC1567715 Nitric oxide activation of guanylyl cyclase in cells revisited Brijesh Roy and John Garthwaite PMCID: PMC1567716 Plant Biology The cotton fiber zinc-binding domain of cellulose synthase A1 from Gossypium hirsutum displays rapid turnover in vitro and in vivo Debora Jacob-Wilk, Isaac Kurek, Patrick Hogan, and Deborah P. Delmer PMCID: PMC1567717 Manipulation of Arabidopsis fatty acid amide hydrolase expression modifies plant growth and sensitivity to N-acylethanolamines Yuh-Shuh Wang, Rhidaya Shrestha, Aruna Kilaru, William Wiant, Barney J. Venables, Kent D. Chapman, and Elison B. Blancaflor PMCID: PMC1567718 Social Sciences Psychology From the Cover:
Phonological typicality influences on-line sentence comprehension Thomas A. Farmer, Morten H. Christiansen, and Padraic Monaghan PMCID: PMC1567719 Correction Correction for Smith et al., Identification of a Plasmodium falciparum intercellular adhesion molecule-1 binding domain: A parasite adhesion trait implicated in cerebral malaria PMCID: PMC1567720 Corrects: M. L. Gardel, et al. Prestressed F-actin networks cross-linked by hinged filamins replicate mechanical properties of cells. Proc Natl Acad Sci U S A. 2006 February 7; 103(6): 1762–1767. |
