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Volume 71(11);  November 1974
Biological Sciences: Biochemistry
Tubulin Synthesis on Polysomes Isolated from Brain and Leg Muscle of Embryonic Chick
Annelise Ø. Jorgensen and Stuart M. Heywood
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4278–4282.
PMCID: PMC433865
Tyrosine Hydroxylase: Activation by Nerve Stimulation
Victor H. Morgenroth, III, Margaret Boadle-Biber, and Robert H. Roth
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4283–4287.
PMCID: PMC433866
Esterification of Low Density Lipoprotein Cholesterol in Human Fibroblasts and Its Absence in Homozygous Familial Hypercholesterolemia
Joseph L. Goldstein, Suzanna E. Dana, and Michael S. Brown
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4288–4292.
PMCID: PMC433867
Proton Magnetic Resonance Spectra of Rhodospirillum rubrum Cytochrome C2
Gary M. Smith and Martin D. Kamen
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4303–4306.
PMCID: PMC433870
lsomeric Phenylalanyl-tRNAs. Position of the Aminoacyl Moiety During Protein Biosynthesis
Sidney M. Hecht, John W. Kozarich, and Francis J. Schmidt
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4317–4321.
PMCID: PMC433873
Regulation of Herpesvirus Macromolecular Synthesis: Nuclear Retention of Nontranslated Viral RNA Sequences
M. Kozak and B. Roizman
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4322–4326.
PMCID: PMC433874
Ovalbumin Messenger RNA: Evidence That the Initial Product of Transcription Is the Same Size as Polysomal Ovalbumin Messenger
G. Stanley McKnight and Robert T. Schimke
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4327–4331.
PMCID: PMC433875
A Pyruvate-Valine Enzyme Complex that is Dependent upon the Metabolic State of the Mitochondria
A. Bergquist, E. A. Eakin, D. K. Murali, and R. P. Wagner
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4352–4355.
PMCID: PMC433881
Effects of Inducers and Epoxide Hydrase on the Metabolism of Benzo[a]pyrene by Liver Microsomes and a Reconstituted System: Analysis by High Pressure Liquid Chromatography
Gerald Holder, Haruhiko Yagi, Patrick Dansette, Donald M. Jerina, W. Levin, Anthony Y. H. Lu, and A. H. Conney
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4356–4360.
PMCID: PMC433882
Amino-Acid Sequence of NADP-Specific Glutamate Dehydrogenase of Neurospora crassa
John C. Wootton, Geoffrey K. Chambers, Anthony A. Holder, Andrew J. Baron, John G. Taylor, John R. S. Fincham, Kenneth M. Blumenthal, Kenneth Moon, and Emil L. Smith
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4361–4365.
PMCID: PMC433883
Polyriboadenylate Sequences at the 3′-Termini of Ribonucleic Acid Obtained from Mammalian Leukemia and Sarcoma Viruses
Leo A. Phillips, James J. Park, and Vincent W. Hollis, Jr.
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4366–4370.
PMCID: PMC433884
Characterization of the End Groups of RNA of Rous Sarcoma Virus
J. Keith, M. Gleason, and H. Fraenkel-Conrat
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4371–4375.
PMCID: PMC433885
Synergistically Stimulated (Na+,K+)-Adenosine Triphosphatase from Plasma Membrane of a Marine Diatom
C. W. Sullivan and B. E. Volcani
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4376–4380.
PMCID: PMC433886
Physical and Physiological Evidence for Two Phase Transitions in Cytoplasmic Membranes of Animal Cells
Bernadine J. Wisnieski, Joel G. Parkes, Yoshie O. Huang, and C. Fred Fox
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4381–4385.
PMCID: PMC433887
A Mutant of Escherichia coli Defective in the Coupling of Metabolic Energy to Active Transport
Michael A. Lieberman and Jen-Shiang Hong
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4395–4399.
PMCID: PMC433891
A Novel Form of RNA Polymerase from Escherichia coli
William Wickner and Arthur Kornberg
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4425–4428.
PMCID: PMC433898
Complex of Aspartate Carbamoyltransferase from Escherichia coli with Its Allosteric Inhibitor, Cytidine Triphosphate: Electron Density at 5.9-Å Resolution
Brian F. P. Edwards, David R. Evans, Stephen G. Warren, Hugo L. Monaco, Scott M. Landfear, George Eisele, James L. Crawford, Don C. Wiley, and William N. Lipscomb
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4437–4441.
PMCID: PMC433901
Cleavage of Replicating Forms of Mitochondrial DNA by EcoRI Endonuclease
Donald L. Robberson, David A. Clayton, and John F. Morrow
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4447–4451.
PMCID: PMC433903
Cooperative Interactions in Aspartate Transcarbamoylase. 1. Hybrids Composed of Native and Chemically Inactivated Catalytic Polypeptide Chains
Ian Gibbons, Ying R. Yang, and H. K. Schachman
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4452–4456.
PMCID: PMC433904
Tunable Laser Resonance Raman Spectroscopy of Bacteriorhodopsin
Aaron Lewis, John Spoonhower, Roberto A. Bogomolni, Richard H. Lozier, and Walther Stoeckenius
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4462–4466.
PMCID: PMC433906
Determination of Actin Messenger RNA in Cultures of Differentiating Embryonic Chick Skeletal Muscle
Bruce M. Paterson, Bryan E. Roberts, and David Yaffe
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4467–4471.
PMCID: PMC433907
Muscle-Like Contractile Proteins and Tubulin in Synaptosomes
A. L. Blitz and R. E. Fine
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4472–4476.
PMCID: PMC433908
Sarcoma-Virus-Related RNA Sequences in Normal Rat Cells
Nobuo Tsuchida, Raymond V. Gilden, and Masakazu Hatanaka
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4503–4507.
PMCID: PMC433915
Glucose Inhibition of Epinephrine Stimulation of Hepatic Gluconeogenesis by Blockade of the α-Receptor Function
Nancy M. Kneer, Anne L. Bosch, Michael G. Clark, and Henry A. Lardy
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4523–4527.
PMCID: PMC433919
Conformational Studies on Arginine Vasopressin and Arginine Vasotocin by Proton Magnetic Resonance Spectroscopy
Roderich Walter, A. Ballardin, I. L. Schwartz, W. A. Gibbons, and H. R. Wyssbrod
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4528–4532.
PMCID: PMC433920
Structure and Molecular Weight of the 60-70S RNA and the 30-40S RNA of the Rous Sarcoma Virus
Walter F. Mangel, Hajo Delius, and Peter H. Duesberg
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4541–4545.
PMCID: PMC433923
Intramolecular Hydrogen Bonding in Flavin Adenine Dinucleotide
Matthew Raszka and Nathan O. Kaplan
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4546–4550.
PMCID: PMC433924
Utilization of Two Distinct Modes of Replication by a Hybrid Plasmid Constructed In Vitro from Separate Replicons
Kenneth Timmis, Felipe Cabello, and Stanley N. Cohen
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4556–4560.
PMCID: PMC433926
Antibody to Myosin: The Specific Visualization of Myosin-Containing Filaments in Nonmuscle Cells
Klaus Weber and Ute Groeschel-Stewart
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4561–4564.
PMCID: PMC433927
Purification and Properties of Rat Liver Microsomal Stearyl Coenzyme A Desaturase
P. Strittmatter, L. Spatz, D. Corcoran, M. J. Rogers, B. Setlow, and R. Redline
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4565–4569.
PMCID: PMC433928
Viable Molecular Hybrids of Bacteriophage Lambda and Eukaryotic DNA
Marjorie Thomas, John R. Cameron, and Ronald W. Davis
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4579–4583.
PMCID: PMC433931
Magnetic Circular Dichroism Studies XXXV. A Comparison of Cytochromes P-450 and P-448
John H. Dawson, Peter M. Dolinger, James R. Trudell, Günter Barth, Robert E. Linder, Edward Bunnenberg, and Carl Djerassi
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4594–4597.
PMCID: PMC433934
Adenylate Cyclase from Brevibacterium liquefaciens. III. In Situ Regulation of Adenylate Cyclase by Pyruvate
Kazuo Umezawa, Katsuji Takai, Shoji Tsuji, Yoshikazu Kurashina, and Osamu Hayaishi
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4598–4601.
PMCID: PMC433935
Glutamine-Binding Subunit of Glutamate Synthase and Partial Reactions Catalyzed by This Glutamine Amidotransferase
Paul P. Trotta, Karen E. B. Platzer, Rudy H. Haschemeyer, and Alton Meister
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4607–4611.
PMCID: PMC433937
Restriction Endonuclease Cleavage Maps of Animal Mitochondrial DNAs
Wesley M. Brown and Jerome Vinograd
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4617–4621.
PMCID: PMC433939
Self Assembly of Histone F2a1
Ruth Sperling and Michael Bustin
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4625–4629.
PMCID: PMC433941
Participation of N1-Oxide derivatives of Adenine Nucleotides in the Phosphotransferase Activity of Liver Mitochondria
G. Jebeleanu, N. G. Ty, H. H. Mantsch, O. Bârzu, G. Niac, and I. Abrudan
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4630–4634.
PMCID: PMC433942
Translational Properties of Rabbit Globin mRNA after Specific Removal of Poly(A) with Ribonuclease H
A. E. Sippel, J. G. Stavrianopoulos, G. Schutz, and P. Feigelson
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4635–4639.
PMCID: PMC433943
Biological Sciences: Biology
Applications of the Survival Theory to Ecology
D. Carl Freeman, Lionel G. Klikoff, and Henry Eyring
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4332–4335.
PMCID: PMC433876
Biological Sciences: Biophysics
The Linkage Between Oxygenation and Subunit Dissociation in Human Hemoglobin
Gary K. Ackers and Herbert R. Halvorson
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4312–4316.
PMCID: PMC433872
Nuclear Coupling of 33S and the Nature of Free Radicals in Irradiated Crystals of Cystine Dihydrochloride: Part II, Charged Radicals
Joseph H. Hadley, Jr. and Walter Gordy
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4409–4413.
PMCID: PMC433894
Piezoelectric Theory of Enzymic Catalysis as Inferred from the Electromechanochemical Principles of Bioenergetics
Giuseppe Caserta and Tommaso Cervigni
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4421–4424.
PMCID: PMC433897
The Chemical and Biological Effects of cis-Dichlorodiammineplatinum (II), an Antitumor Agent, on DNA
Linda L. Munchausen
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4519–4522.
PMCID: PMC433918
Biological Sciences: Cell Biology
Differential Lectin Agglutination of Fetal, Dividing-Postnatal, and Malignant Hepatocytes
F. F. Becker
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4307–4311.
PMCID: PMC433871
Characterization of Binding Components for Progesterone and 5α-Pregnane-3,20-dione in the Hamster Uterus
Wendell W. Leavitt and Charles J. Grossman
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4341–4345.
PMCID: PMC433878
Biological Membranes as Bilayer Couples. A Molecular Mechanism of Drug-Erythrocyte Interactions
Michael P. Sheetz and S. J. Singer
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4457–4461.
PMCID: PMC433905
Phosphoprotein Phosphatase Activity Associated with Estrogen-Induced Protein in Rat Uterus
Alain Vokaer, Stefano Iacobelli, and Raphaël Kram
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4482–4486.
PMCID: PMC433910
Gap Junction Formation Between Reaggregated Novikoff Hepatoma Cells
Ross Johnson, Marie Hammer, Judson Sheridan, and Jean-Paul Revel
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4536–4540.
PMCID: PMC433922
Regulation of Hemoglobin Synthesis in a Murine Erythroblastic Leukemic Cell: The Requirement for Replication to Induce Hemoglobin Synthesis
Patrick R. McClintock and John Papaconstantinou
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4551–4555.
PMCID: PMC433925
Behavior of Three Types of Ribovirus-Like Particles in Segregating Hamster × Mouse Somatic Hybrids
Y. Yotsuyanagi and Boris Ephrussi
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4575–4578.
PMCID: PMC433930
Stimulation of Division of Sparse and Confluent 3T3 Cell Populations by a Fibroblast Growth Factor, Dexamethasone, and Insulin
Denis Gospodarowicz and John S. Moran
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4584–4588.
PMCID: PMC433932
Direct Evidence for Fluid Membranes
Sidney L. Tamm and Signhild Tamm
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4589–4593.
PMCID: PMC433933
Biological Sciences: Genetics
An Analysis of Survival in Haploid and Diploid Cell Cultures after Exposure to ICR Acridine Half-mustard Compounds Mutagenic for Bacteria
Liselotte Mezger-Freed
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4416–4420.
PMCID: PMC433896
A Manyfold Increase in Sister Chromatid Exchanges in Bloom's Syndrome Lymphocytes
R. S. K. Chaganti, S. Schonberg, and James German
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4508–4512.
PMCID: PMC433916
Evolution of Type C Viral Genes: I. Nucleic Acid from Baboon Type C Virus as a Measure of Divergence among Primate Species
Raoul E. Benveniste and George J. Todaro
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4513–4518.
PMCID: PMC433917
Mitochondrial Genetics in Bakers' Yeast: A Molecular Mechanism for Recombinational Polarity and Suppressiveness
Philip S. Perlman and C. William Birky, Jr.
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4612–4616.
PMCID: PMC433938
Biological Sciences: Immunology
An Inhibitor of Cell Proliferation Released by Cultures of Macrophages
Jesus Calderon, Richard T. Williams, and Emil R. Unanue
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4273–4277.
PMCID: PMC433864
The Three-Dimensional Structure of a Phosphorylcholine-Binding Mouse Immunoglobulin Fab and the Nature of the Antigen Binding Site
David M. Segal, Eduardo A. Padlan, Gerson H. Cohen, Stuart Rudikoff, Michael Potter, and David R. Davies
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4298–4302.
PMCID: PMC433869
On the Chemical Nature of Transfer Factor
David Dressler and Steven Rosenfeld
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4429–4434.
PMCID: PMC433899
Similar Idiotypes in Antibody-Forming Cells and in Cells Synthesizing Immunoglobulins Without Detectable Antibody Function
P. -A. Cazenave, T. Ternynck, and S. Avrameas
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4500–4502.
PMCID: PMC433914
Visual Detection of Hepatitis B Antigen
Ivar Giaever and Robert J. Laffin
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4533–4535.
PMCID: PMC433921
Biological Sciences: Medical Sciences
Cobalt Induction of Hepatic Heme Oxygenase; with Evidence That Cytochrome P-450 Is Not Essential for This Enzyme Activity
M. D. Maines and Attallah Kappas
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4293–4297.
PMCID: PMC433868
Particles with Characteristics of Leukoviruses in Cultures of Marrow Cells from Leukemic Patients in Remission and Relapse
T. W. Mak, J. Manaster, A. F. Howatson, E. A. McCulloch, and J. E. Till
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4336–4340.
PMCID: PMC433877
Terminal Deoxyribonucleotidyl Transferase in Human Leukemia
Mary Sue Coleman, John J. Hutton, Philip De Simone, and F. J. Bollum
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4404–4408.
PMCID: PMC433893
Are Recommended Daily Allowances for Vitamin C Adequate?
Linus Pauling
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4442–4446.
PMCID: PMC433902
Idiotypic Specificity of Surface Immunoglobulin and the Maturation of Leukemic Bone-marrow-derived Lymphocytes
S. M. Fu, R. J. Winchester, T. Feizi, P. D. Walzer, and H. G. Kunkel
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4487–4490.
PMCID: PMC433911
Biological Sciences: Physiology
A Test of the Hypothesis That D2O Affects Circadian Oscillations by Diminishing the Apparent Temperature
Patricia C. Caldarola and Colin S. Pittendrigh
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4386–4388.
PMCID: PMC433888
Heavy Water Slows the Gonyaulax Clock: A Test of the Hypothesis That D2O Affects Circadian Oscillations by Diminishing the Apparent Temperature
Martha McDaniel, Frank M. Sulzman, and J. W. Hastings
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4389–4391.
PMCID: PMC433889
Significance of Plasma Dopamine β-Hydroxylase Activity as an Index of Sympathetic Neuronal Function
John L. Reid and Irwin J. Kopin
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4392–4394.
PMCID: PMC433890
Biosynthesis of Tyrosine Hydroxylase in Rat Adrenal Medulla after Exposure to Cold
De-Maw Chuang and E. Costa
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4570–4574.
PMCID: PMC433929
Physical Sciences: Astronomy
Chemical Composition of Nebulosities in the Magellanic Clouds
L. H. Aller, S. J. Czyzak, C. D. Keyes, and G. Boeshaar
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4496–4499.
PMCID: PMC433913
Physical Sciences: Chemistry
Pyrrole Hydrogen Ionization of Imidazole Derivatives in Metal Ion Complexes and Carbonic Anhydrase
R. Bruce Martin
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4346–4347.
PMCID: PMC433879
On the Mechanism of Oscillations in the “Beating Mercury Heart”
Shu-Wai Lin, Joel Keizer, Peter A. Rock, and Herbert Stenschke
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4477–4481.
PMCID: PMC433909
Parametric Analysis of Conductance Data
Raymond M. Fuoss
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4491–4495.
PMCID: PMC433912
Physical Sciences: Geophysics
Alignment of the Earth's Magnetic Field with the Axis of Rotation and Reversals of Polarity: Laboratory Experiments on a Mechanism
H. R. Crane
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4400–4403.
PMCID: PMC433892
Physical Sciences: Mathematics
Closed Leaves in Foliated 3-Manifolds
Sue Goodman
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4414–4415.
PMCID: PMC433895
Singular Integrals and the Principal Series, III
A. W. Knapp and E. M. Stein
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4622–4624.
PMCID: PMC433940
Physical Sciences: Physics
Serendibite, a Complicated, New, Inorganic Crystal Structure
Martin J. Buerger and V. Venkatakrishnan
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4348–4351.
PMCID: PMC433880
Physical Sciences: Statistics
A Sequential Test for Two Binomial Populations
Herbert Robbins
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4435–4436.
PMCID: PMC433900
Social Sciences: Political Science
A New Method for Congressional Apportionment
M. L. Balinski and H. P. Young
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4602–4606.
PMCID: PMC433936
Corrections
Conformational analysis of thyrotropin releasing factor
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4640.
PMCID: PMC433944
Corrects: Antony W. Burgess, et al. Conformational Analysis of Thyrotropin Releasing Factor. Proc Natl Acad Sci U S A. 1973 May; 70(5): 1456–1460.
Isolation of exonuclease VIII: The enzyme associated with the sbcA indirect suppressor
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4640.
PMCID: PMC433945
Corrects: Sidney R. Kushner, et al. Isolation of Exonuclease VIII: The Enzyme Associated with the sbcA Indirect Suppressor. Proc Natl Acad Sci U S A. 1974 September; 71(9): 3593–3597.
The density of acetylcholine receptors and their sensitivity in the postsynaptic membrane of muscle endplates
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4640.
PMCID: PMC433946
Corrects: Edson X. Albuquerque, et al. The Density of Acetylcholine Receptors and Their Sensitivity in the Postsynaptic Membrane of Muscle Endplates. Proc Natl Acad Sci U S A. 1974 July; 71(7): 2818–2822.
Nonasymptotic species richness models and the insects of British trees
Proc Natl Acad Sci U S A. 1974 November; 71(11): 4640.
PMCID: PMC433947
Corrects: Donald R. Strong, Jr.. Nonasymptotic Species Richness Models and the Insects of British Trees. Proc Natl Acad Sci U S A. 1974 July; 71(7): 2766–2769.
Journal Matter
Original table of contents page
Administrative content — journal masthead, notices, indexes, etc.
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