| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2006 April 4; 103(14): 5243–5244. doi: 10.1073/iti1406103.PMCID: PMC1459337 Commentaries You can't always get what you want: Conservation planning with feedback effects Stephen Polasky PMCID: PMC1459338 mTOR is out of control in polycystic kidney disease Keith E. Mostov PMCID: PMC1459339 How TRIM5α defends against retroviral invasions Michael Emerman PMCID: PMC1459340 Perspective Approaches for biological and biomimetic energy conversion David A. LaVan and Jennifer N. Cha PMCID: PMC1459341 Profiles Profile of Robert M. Stroud Tinsley H. Davis PMCID: PMC1459342 Profile of Peter Walter Tinsley H. Davis PMCID: PMC1459343 Physical Sciences Applied Mathematics Messages diffuse faster than messengers Bernardo Pando, Silvina Ponce Dawson, Don-On Daniel Mak, and John E. Pearson PMCID: PMC1414799 Chemistry From the Cover:
A physical model of axonal damage due to oxidative stress Anne E. Counterman, Terrence G. D'Onofrio, Anne Milasincic Andrews, and Paul S. Weiss PMCID: PMC1459344 Substrate binding in quinoprotein ethanol dehydrogenase from Pseudomonas aeruginosa studied by electron-nuclear double resonance Christopher W. M. Kay, Bina Mennenga, Helmut Görisch, and Robert Bittl PMCID: PMC1459345 A simple artificial light-harvesting dyad as a model for excess energy dissipation in oxygenic photosynthesis Rudi Berera, Christian Herrero, Ivo H. M. van Stokkum, Mikas Vengris, Gerdenis Kodis, Rodrigo E. Palacios, Herbert van Amerongen, Rienk van Grondelle, Devens Gust, Thomas A. Moore, Ana L. Moore, and John T. M. Kennis PMCID: PMC1414798 Physics Simulation of polymer translocation through protein channels M. Muthukumar and C. Y. Kong PMCID: PMC1551897 The inherent structure landscape of a protein Naoko Nakagawa and Michel Peyrard PMCID: PMC1459346 Biological Sciences Agricultural Sciences Suppression of prion protein in livestock by RNA interference Michael C. Golding, Charles R. Long, Michelle A. Carmell, Gregory J. Hannon, and Mark E. Westhusin PMCID: PMC1459347 Biochemistry Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4 Kyouhei Arita, Toshiyuki Shimizu, Hiroshi Hashimoto, Yuji Hidaka, Michiyuki Yamada, and Mamoru Sato PMCID: PMC1459348 From the Cover:
NifB-dependent in vitro synthesis of the iron–molybdenum cofactor of nitrogenase Leonardo Curatti, Paul W. Ludden, and Luis M. Rubio PMCID: PMC1414635 Solution structure of the N-domain of Wilson disease protein: Distinct nucleotide-binding environment and effects of disease mutations Oleg Dmitriev, Ruslan Tsivkovskii, Frits Abildgaard, Clinton T. Morgan, John L. Markley, and Svetlana Lutsenko PMCID: PMC1459350 NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression Adam Rosendorff, Shuhei Sakakibara, Sixin Lu, Elliott Kieff, Yan Xuan, Alessandra DiBacco, Yujiang Shi, Yang Shi, and Grace Gill PMCID: PMC1459351 A protein interaction surface in nonribosomal peptide synthesis mapped by combinatorial mutagenesis and selection Jonathan R. Lai, Michael A. Fischbach, David R. Liu, and Christopher T. Walsh PMCID: PMC1459352 A high-resolution map of transcription in the yeast genome Lior David, Wolfgang Huber, Marina Granovskaia, Joern Toedling, Curtis J. Palm, Lee Bofkin, Ted Jones, Ronald W. Davis, and Lars M. Steinmetz PMCID: PMC1414796 Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3 Sijiu Liu, Jin-Peng Sun, Bo Zhou, and Zhong-Yin Zhang PMCID: PMC1459354 Insights into transcriptional regulation and σ competition from an equilibrium model of RNA polymerase binding to DNA Irina L. Grigorova, Naum J. Phleger, Vivek K. Mutalik, and Carol A. Gross PMCID: PMC1459355 Biophysics From the Cover:
A physical model of axonal damage due to oxidative stress Anne E. Counterman, Terrence G. D'Onofrio, Anne Milasincic Andrews, and Paul S. Weiss PMCID: PMC1459344 Substrate binding in quinoprotein ethanol dehydrogenase from Pseudomonas aeruginosa studied by electron-nuclear double resonance Christopher W. M. Kay, Bina Mennenga, Helmut Görisch, and Robert Bittl PMCID: PMC1459345 Simulation of polymer translocation through protein channels M. Muthukumar and C. Y. Kong PMCID: PMC1551897 The inherent structure landscape of a protein Naoko Nakagawa and Michel Peyrard PMCID: PMC1459346 Messages diffuse faster than messengers Bernardo Pando, Silvina Ponce Dawson, Don-On Daniel Mak, and John E. Pearson PMCID: PMC1414799 A simple artificial light-harvesting dyad as a model for excess energy dissipation in oxygenic photosynthesis Rudi Berera, Christian Herrero, Ivo H. M. van Stokkum, Mikas Vengris, Gerdenis Kodis, Rodrigo E. Palacios, Herbert van Amerongen, Rienk van Grondelle, Devens Gust, Thomas A. Moore, Ana L. Moore, and John T. M. Kennis PMCID: PMC1414798 The influence of chromosome flexibility on chromosome transport during anaphase A Arjun Raj and Charles S. Peskin PMCID: PMC1459358 Chlorella virus MT325 encodes water and potassium channels that interact synergistically Sabrina Gazzarrini, Ming Kang, Svetlana Epimashko, James L. Van Etten, Jack Dainty, Gerhard Thiel, and Anna Moroni PMCID: PMC1414795 Physically realistic homology models built with rosetta can be more accurate than their templates Kira M. S. Misura, Dylan Chivian, Carol A. Rohl, David E. Kim, and David Baker PMCID: PMC1459360 Folding-based molecular simulations reveal mechanisms of the rotary motor F1–ATPase Nobuyasu Koga and Shoji Takada PMCID: PMC1459361 Cell Biology The zebrafish homologue of mammalian chimerin Rac-GAPs is implicated in epiboly progression during development Federico Coluccio Leskow, Beth A. Holloway, HongBin Wang, Mary C. Mullins, and Marcelo G. Kazanietz PMCID: PMC1459362 Mitochondria as signaling organelles in the vascular endothelium Marisol Quintero, Sergio L. Colombo, Andrew Godfrey, and Salvador Moncada PMCID: PMC1459363 Cytoplasmic γ-actin contributes to a compensatory remodeling response in dystrophin-deficient muscle Laurin M. Hanft, Inna N. Rybakova, Jitandrakumar R. Patel, Jill A. Rafael-Fortney, and James M. Ervasti PMCID: PMC1459364 Phosphoproteome analysis of the human mitotic spindle Marjaana Nousiainen, Herman H. W. Silljé, Guido Sauer, Erich A. Nigg, and Roman Körner PMCID: PMC1459365 Developmental Biology PR130 is a modulator of the Wnt-signaling cascade that counters repression of the antagonist Naked cuticle Menno P. Creyghton, Giulietta Roël, Pieter J. A. Eichhorn, Liesbeth C. Vredeveld, Olivier Destrée, and René Bernards PMCID: PMC1414636 Ecology From the Cover:
Land market feedbacks can undermine biodiversity conservation Paul R. Armsworth, Gretchen C. Daily, Peter Kareiva, and James N. Sanchirico PMCID: PMC1459367 Environmental Sciences Green primaries: Environmentally friendly energetic complexes My Hang V. Huynh, Michael A. Hiskey, Thomas J. Meyer, and Modi Wetzler PMCID: PMC1459368 Hyperaccumulation of arsenic in the shoots of Arabidopsis silenced for arsenate reductase (ACR2) Om Parkash Dhankher, Barry P. Rosen, Elizabeth C. McKinney, and Richard B. Meagher PMCID: PMC1459369 Evolution Evolution of cis elements in the differential expression of two Hoxa2 coparalogous genes in pufferfish (Takifugu rubripes) Stefan Tümpel, Francisco Cambronero, Leanne M. Wiedemann, and Robb Krumlauf PMCID: PMC1459370 Neutral and adaptive variation in gene expression Andrew Whitehead and Douglas L. Crawford PMCID: PMC1414633 Simple and accurate estimation of ancestral protein sequences Barry G. Hall PMCID: PMC1459372 New primate genus from the Miocene of Argentina Marcelo F. Tejedor, Adán A. Tauber, Alfred L. Rosenberger, Carl C. Swisher, III, and María E. Palacios PMCID: PMC1459373 The evolutionary diversification of cyanobacteria: Molecular–phylogenetic and paleontological perspectives Akiko Tomitani, Andrew H. Knoll, Colleen M. Cavanaugh, and Terufumi Ohno PMCID: PMC1459374 Genetics Phylogenetic fate mapping Stephen J. Salipante and Marshall S. Horwitz PMCID: PMC1414797 Immunology Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines T. Pukrop, F. Klemm, Th. Hagemann, D. Gradl, M. Schulz, S. Siemes, L. Trümper, and C. Binder PMCID: PMC1459376 Suppression of natural killer cell-mediated bone marrow cell rejection by CD4+CD25+ regulatory T cells Isabel Barao, Alan M. Hanash, William Hallett, Lisbeth A. Welniak, Kai Sun, Doug Redelman, Bruce R. Blazar, Robert B. Levy, and William J. Murphy PMCID: PMC1459377 Medical Sciences From the Cover:
The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease Jonathan M. Shillingford, Noel S. Murcia, Claire H. Larson, Seng Hui Low, Ryan Hedgepeth, Nicole Brown, Chris A. Flask, Andrew C. Novick, David A. Goldfarb, Albrecht Kramer-Zucker, Gerd Walz, Klaus B. Piontek, Gregory G. Germino, and Thomas Weimbs PMCID: PMC1459378 Complex haplotypes derived from noncoding polymorphisms of the intronless α2A-adrenergic gene diversify receptor expression Kersten M. Small, Kari M. Brown, Carrie A. Seman, Cheryl T. Theiss, and Stephen B. Liggett PMCID: PMC1459379 Gene expression patterns in human placenta Ruchira Sood, James L. Zehnder, Maurice L. Druzin, and Patrick O. Brown PMCID: PMC1414632 Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis Tomoyuki Inoue, David L. Boyle, Maripat Corr, Deepa Hammaker, Roger J. Davis, Richard A. Flavell, and Gary S. Firestein PMCID: PMC1459381 FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts Kyoko Kakumoto, Ken Sasai, Taiko Sukezane, Chitose Oneyama, Satoshi Ishimaru, Kana Shibutani, Hiroto Mizushima, Eisuke Mekada, Hidesaburo Hanafusa, and Tsuyoshi Akagi PMCID: PMC1459382 Life stress and diminished expression of genes encoding glucocorticoid receptor and β2-adrenergic receptor in children with asthma Gregory E. Miller and Edith Chen PMCID: PMC1414639 Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase Thomas Naderer, Miriam A. Ellis, M. Fleur Sernee, David P. De Souza, Joan Curtis, Emanuela Handman, and Malcolm J. McConville PMCID: PMC1459384 Construction and properties of a herpes simplex virus 1 designed to enter cells solely via the IL-13α2 receptor Guoying Zhou and Bernard Roizman PMCID: PMC1459385 Microbiology From the Cover:
Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5α restriction factor Matthew Stremlau, Michel Perron, Mark Lee, Yuan Li, Byeongwoon Song, Hassan Javanbakht, Felipe Diaz-Griffero, Donovan J. Anderson, Wesley I. Sundquist, and Joseph Sodroski PMCID: PMC1459386 Bottleneck-mediated quasispecies restriction during spread of an RNA virus from inoculation site to brain Julie K. Pfeiffer and Karla Kirkegaard PMCID: PMC1414638 Role of the Yersinia pestis plasminogen activator in the incidence of distinct septicemic and bubonic forms of flea-borne plague Florent Sebbane, Clayton O. Jarrett, Donald Gardner, Daniel Long, and B. Joseph Hinnebusch PMCID: PMC1414629 Na+/H+ exchanger type 1 is a receptor for pathogenic subgroup J avian leukosis virus Ning Chai and Paul Bates PMCID: PMC1459389 Neuroscience Transfer characteristics of the hair cell’s afferent synapse Erica C. Keen and A. J. Hudspeth PMCID: PMC1414630 Songbirds tune their vocal tract to the fundamental frequency of their song Tobias Riede, Roderick A. Suthers, Neville H. Fletcher, and William E. Blevins PMCID: PMC1459391 Molecular evidence for two-stage learning and partial laterality in eyeblink conditioning of mice Jin-Sung Park, Takashi Onodera, Shin-ichi Nishimura, Richard F. Thompson, and Shigeyoshi Itohara PMCID: PMC1414800 Specific T-type calcium channel isoforms are associated with distinct burst phenotypes in deep cerebellar nuclear neurons Michael L. Molineux, John E. McRory, Bruce E. McKay, Jawed Hamid, W. Hamish Mehaffey, Renata Rehak, Terrance P. Snutch, Gerald W. Zamponi, and Ray W. Turner PMCID: PMC1459392 A functional AMPA receptor–calcium channel complex in the postsynaptic membrane Myoung-Goo Kang, Chien-Chang Chen, Minoru Wakamori, Yuji Hara, Yasuo Mori, and Kevin P. Campbell PMCID: PMC1459393 In vivo diffusion analysis with quantum dots and dextrans predicts the width of brain extracellular space Robert G. Thorne and Charles Nicholson PMCID: PMC1459394 Reelin expression and glycosylation patterns are altered in Alzheimer’s disease Arancha Botella-López, Ferran Burgaya, Rosalina Gavín, M. Salud García-Ayllón, Estrella Gómez-Tortosa, Jordi Peña-Casanova, Jesús M. Ureña, José A. Del Río, Rafael Blesa, Eduardo Soriano, and Javier Sáez-Valero PMCID: PMC1414634 Integrin-driven actin polymerization consolidates long-term potentiation Enikö A. Kramár, Bin Lin, Christopher S. Rex, Christine M. Gall, and Gary Lynch PMCID: PMC1459396 Glucocorticoids reduce phobic fear in humans Leila M. Soravia, Markus Heinrichs, Amanda Aerni, Caroline Maroni, Gustav Schelling, Ulrike Ehlert, Benno Roozendaal, and Dominique J.-F. de Quervain PMCID: PMC1414637 The expression of the clock protein PER2 in the limbic forebrain is modulated by the estrous cycle Jennifer S. Perrin, Lauren A. Segall, Valerie L. Harbour, Barbara Woodside, and Shimon Amir PMCID: PMC1459398 Neuronal metabolism governs cortical network response state M. O. Cunningham, D. D. Pervouchine, C. Racca, N. J. Kopell, C. H. Davies, R. S. G. Jones, R. D. Traub, and M. A. Whittington PMCID: PMC1459399 Plant Biology Costs and benefits of priming for defense in Arabidopsis Marieke van Hulten, Maaike Pelser, L. C. van Loon, Corné M. J. Pieterse, and Jurriaan Ton PMCID: PMC1459400 l-Tartaric acid synthesis from vitamin C in higher plants Seth DeBolt, Douglas R. Cook, and Christopher M. Ford PMCID: PMC1459401 Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells Heiko Rischer, Matej Orešič, Tuulikki Seppänen-Laakso, Mikko Katajamaa, Freya Lammertyn, Wilson Ardiles-Diaz, Marc C. E. Van Montagu, Dirk Inzé, Kirsi-Marja Oksman-Caldentey, and Alain Goossens PMCID: PMC1459402 Population Biology Controlling methicillin-resistant Staphylococcus aureus: Quantifying the effects of interventions and rapid diagnostic testing M. C. J. Bootsma, O. Diekmann, and M. J. M. Bonten PMCID: PMC1459403 Sustainability Science From the Cover:
Land market feedbacks can undermine biodiversity conservation Paul R. Armsworth, Gretchen C. Daily, Peter Kareiva, and James N. Sanchirico PMCID: PMC1459367 Social Sciences Psychology Perceptual moments of conscious visual experience inferred from oscillatory brain activity Marie L. Smith, Frédéric Gosselin, and Philippe G. Schyns PMCID: PMC1459404 Corrections Correction for Nébavi et al., Clonal population structure and genetic diversity of Candida albicans in AIDS patients from Abidjan (Côte d’Ivoire) François Nébavi, Francisco J. Ayala, François Renaud, Sébastien Bertout, Serge Eholié, Koné Moussa, Michèle Mallié, and Thierry de Meeûs PMCID: PMC1459405 Corrects: François Nébavi, et al. Clonal population structure and genetic diversity of Candida albicans in AIDS patients from Abidjan (Côte d’Ivoire). Proc Natl Acad Sci U S A. 2006 March 7; 103(10): 3663–3668. Correction for Dooley et al,. First molecular and biochemical analysis of in vivo affinity maturation in an ectothermic vertebrate PMCID: PMC1459406 Corrects: Helen Dooley, et al. First molecular and biochemical analysis of in vivo affinity maturation in an ectothermic vertebrate. Proc Natl Acad Sci U S A. 2006 February 7; 103(6): 1846–1851. Correction for Swanson et al,. For the article Anxiolytic- and antidepressantlike profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299 PMCID: PMC1459407 Corrects: Chad J. Swanson, et al. From the Cover:
Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299. Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17489–17494. |
