| | This journal provides immediate access to some articles. Retrospective In Memoriam: PNAS Editor-in-Chief Nicholas R. Cozzarelli (1938–2006) Regina Nuzzo and Nick Zagorski PMCID: PMC1458831 This Week in PNAS Proc Natl Acad Sci U S A. 2006 April 18; 103(16): 6075–6076. doi: 10.1073/iti1606103.PMCID: PMC1458829 Editorial The Nick Cozzarelli I Knew Bruce Alberts PMCID: PMC1458830 Commentaries Picrotoxin-like channel blockers of GABAA receptors Richard W. Olsen PMCID: PMC1458832 Discontinuities in ecological data Craig R. Allen PMCID: PMC1458833 Genes for susceptibility to violence lurk in the brain Essi Viding and Uta Frith PMCID: PMC1458834 Multiple sclerosis may disrupt endocannabinoid brain protection mechanism Esther Shohami and Raphael Mechoulam PMCID: PMC1458835 Perspective Nobel Lecture An astonishing 60 years: The legacy of Hiroshima Thomas C. Schelling PMCID: PMC1458836 Physical Sciences Applied Physical Sciences Sparse time-frequency representations Timothy J. Gardner and Marcelo O. Magnasco PMCID: PMC1431718 Switchable electro-optic diffractive lens with high efficiency for ophthalmic applications Guoqiang Li, David L. Mathine, Pouria Valley, Pekka Äyräs, Joshua N. Haddock, M. S. Giridhar, Gregory Williby, Jim Schwiegerling, Gerald R. Meredith, Bernard Kippelen, Seppo Honkanen, and Nasser Peyghambarian PMCID: PMC1458838 Chemistry From the Cover:
Symmetry-, time-, and temperature-dependent strength of carbon nanotubes Traian Dumitrica, Ming Hua, and Boris I. Yakobson PMCID: PMC1421334 Engineering From the Cover:
Symmetry-, time-, and temperature-dependent strength of carbon nanotubes Traian Dumitrica, Ming Hua, and Boris I. Yakobson PMCID: PMC1421334 Optimal vortex formation as an index of cardiac health Morteza Gharib, Edmond Rambod, Arash Kheradvar, David J. Sahn, and John O. Dabiri PMCID: PMC1458873 Environmental Sciences Tropical drying trends in global warming models and observations J. D. Neelin, M. Münnich, H. Su, J. E. Meyerson, and C. E. Holloway PMCID: PMC1435369 Mathematics Finite simple groups as expanders Martin Kassabov, Alexander Lubotzky, and Nikolay Nikolov PMCID: PMC1458841 Betti numbers of holomorphic symplectic quotients via arithmetic Fourier transform Tamás Hausel PMCID: PMC1559787 Physics Interference between independent fluctuating condensates Anatoli Polkovnikov, Ehud Altman, and Eugene Demler PMCID: PMC1458842 Biological Sciences Biochemistry Evidence for C–H cleavage by an iron–superoxide complex in the glycol cleavage reaction catalyzed by myo-inositol oxygenase Gang Xing, Yinghui Diao, Lee M. Hoffart, Eric W. Barr, K. Sandeep Prabhu, Ryan J. Arner, C. Channa Reddy, Carsten Krebs, and J. Martin Bollinger, Jr. PMCID: PMC1458843 Toward understanding actin activation of myosin ATPase: The role of myosin surface loops Hirofumi Onishi, Sergey V. Mikhailenko, and Manuel F. Morales PMCID: PMC1434513 Partnering between monomers of cyclooxygenase-2 homodimers Chong Yuan, Caroline Jill Rieke, Gilad Rimon, Byron A. Wingerd, and William L. Smith PMCID: PMC1458845 The mechanism of M.HhaI DNA C5 cytosine methyltransferase enzyme: A quantum mechanics/molecular mechanics approach Xiaodong Zhang and Thomas C. Bruice PMCID: PMC1458846 Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis Yi Gong, Joon No Lee, Michael S. Brown, Joseph L. Goldstein, and Jin Ye PMCID: PMC1435366 Bispecific Abs against modified protein and DNA with oxidized lipids Mitsugu Akagawa, Sohei Ito, Kazuyo Toyoda, Yoshihisa Ishii, Emi Tatsuda, Takahiro Shibata, Satoru Yamaguchi, Yoshichika Kawai, Kousuke Ishino, Yusuke Kishi, Takahiro Adachi, Takeshi Tsubata, Yoshinari Takasaki, Nobutaka Hattori, Tsukasa Matsuda, and Koji Uchida PMCID: PMC1458848 Hsp70 chaperones accelerate protein translocation and the unfolding of stable protein aggregates by entropic pulling Paolo De Los Rios, Anat Ben-Zvi, Olga Slutsky, Abdussalam Azem, and Pierre Goloubinoff PMCID: PMC1458849 Chaperone-mediated assembly of centromeric chromatin in vitro Takehito Furuyama, Yamini Dalal, and Steven Henikoff PMCID: PMC1431717 Balance between DBT/CKIε kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK protein Eun Young Kim and Isaac Edery PMCID: PMC1458851 Biophysics Sparse time-frequency representations Timothy J. Gardner and Marcelo O. Magnasco PMCID: PMC1431718 Nanoindentation studies of full and empty viral capsids and the effects of capsid protein mutations on elasticity and strength J. P. Michel, I. L. Ivanovska, M. M. Gibbons, W. S. Klug, C. M. Knobler, G. J. L. Wuite, and C. F. Schmidt PMCID: PMC1458852 Nanomechanical measurements of the sequence-dependent folding landscapes of single nucleic acid hairpins Michael T. Woodside, William M. Behnke-Parks, Kevan Larizadeh, Kevin Travers, Daniel Herschlag, and Steven M. Block PMCID: PMC1458853 Cell Biology Spatiotemporal control of spindle midzone formation by PRC1 in human cells Changjun Zhu, Eric Lau, Robert Schwarzenbacher, Ella Bossy-Wetzel, and Wei Jiang PMCID: PMC1458854 Vta1p and Vps46p regulate the membrane association and ATPase activity of Vps4p at the yeast multivesicular body Jillian M. Lottridge, Andrew R. Flannery, Jennifer L. Vincelli, and Tom H. Stevens PMCID: PMC1458855 Developmental Biology From the Cover:
Transgenic Hydra allow in vivo tracking of individual stem cells during morphogenesis Jörg Wittlieb, Konstantin Khalturin, Jan U. Lohmann, Friederike Anton-Erxleben, and Thomas C. G. Bosch PMCID: PMC1458856 Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway Jee Young An, Jai Wha Seo, Takafumi Tasaki, Min Jae Lee, Alexander Varshavsky, and Yong Tae Kwon PMCID: PMC1458857 Making the gradient: Thyroid hormone regulates cone opsin expression in the developing mouse retina Melanie R. Roberts, Maya Srinivas, Douglas Forrest, Gabriella Morreale de Escobar, and Thomas A. Reh PMCID: PMC1458858 The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation Catriona H. M. Jamieson, Jason Gotlib, Jeffrey A. Durocher, Mark P. Chao, M. Rajan Mariappan, Marla Lay, Carol Jones, James L. Zehnder, Stan L. Lilleberg, and Irving L. Weissman PMCID: PMC1434515 Ecology From the Cover:
Self-organized similarity, the evolutionary emergence of groups of similar species Marten Scheffer and Egbert H. van Nes PMCID: PMC1458860 Classic flea-borne transmission does not drive plague epizootics in prairie dogs Colleen T. Webb, Christopher P. Brooks, Kenneth L. Gage, and Michael F. Antolin PMCID: PMC1434514 Global traffic and disease vector dispersal Andrew J. Tatem, Simon I. Hay, and David J. Rogers PMCID: PMC1435368 Antarctic birds breed later in response to climate change Christophe Barbraud and Henri Weimerskirch PMCID: PMC1458863 Environmental Sciences The molecular basis for differential dioxin sensitivity in birds: Role of the aryl hydrocarbon receptor Sibel I. Karchner, Diana G. Franks, Sean W. Kennedy, and Mark E. Hahn PMCID: PMC1435364 Evolution Breakpoint structure reveals the unique origin of an interspecific chromosomal inversion (2La) in the Anopheles gambiae complex Igor V. Sharakhov, Bradley J. White, Maria V. Sharakhova, Jonathan Kayondo, Neil F. Lobo, Federica Santolamazza, Alessandra della Torre, Frédéric Simard, Frank H. Collins, and Nora J. Besansky PMCID: PMC1458865 A Dirichlet process model for detecting positive selection in protein-coding DNA sequences John P. Huelsenbeck, Sonia Jain, Simon W. D. Frost, and Sergei L. Kosakovsky Pond PMCID: PMC1458866 Genetics From the Cover:
Neural mechanisms of genetic risk for impulsivity and violence in humans Andreas Meyer-Lindenberg, Joshua W. Buckholtz, Bhaskar Kolachana, Ahmad R. Hariri, Lukas Pezawas, Giuseppe Blasi, Ashley Wabnitz, Robyn Honea, Beth Verchinski, Joseph H. Callicott, Michael Egan, Venkata Mattay, and Daniel R. Weinberger PMCID: PMC1458867 DNA motifs in human and mouse proximal promoters predict tissue-specific expression Andrew D. Smith, Pavel Sumazin, Zhenyu Xuan, and Michael Q. Zhang PMCID: PMC1458868 Mutations in fibroblast growth factor receptor 1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism Nelly Pitteloud, James S. Acierno, Jr., Astrid Meysing, Anna V. Eliseenkova, Jinghong Ma, Omar A. Ibrahimi, Daniel L. Metzger, Frances J. Hayes, Andrew A. Dwyer, Virginia A. Hughes, Maria Yialamas, Janet E. Hall, Ellen Grant, Moosa Mohammadi, and William F. Crowley, Jr. PMCID: PMC1458869 Homozygosity mapping with SNP arrays identifies TRIM32, an E3 ubiquitin ligase, as a Bardet–Biedl syndrome gene (BBS11) Annie P. Chiang, John S. Beck, Hsan-Jan Yen, Marwan K. Tayeh, Todd E. Scheetz, Ruth E. Swiderski, Darryl Y. Nishimura, Terry A. Braun, Kwang-Youn A. Kim, Jian Huang, Khalil Elbedour, Rivka Carmi, Diane C. Slusarski, Thomas L. Casavant, Edwin M. Stone, and Val C. Sheffield PMCID: PMC1458870 Immunology Phenotypically distinct B cell development pathways map to the three B cell lineages in the mouse James W. Tung, Matthew D. Mrazek, Yang Yang, Leonard A. Herzenberg, and Leonore A. Herzenberg PMCID: PMC1458871 The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction Daniel C. Rowe, Anne F. McGettrick, Eicke Latz, Brian G. Monks, Nicholas J. Gay, Masahiro Yamamoto, Shizuo Akira, Luke A. O’Neill, Katherine A. Fitzgerald, and Douglas T. Golenbock PMCID: PMC1458872 Medical Sciences Optimal vortex formation as an index of cardiac health Morteza Gharib, Edmond Rambod, Arash Kheradvar, David J. Sahn, and John O. Dabiri PMCID: PMC1458873 Activation and repolarization of the normal human heart under complete physiological conditions Charulatha Ramanathan, Ping Jia, Raja Ghanem, Kyungmoo Ryu, and Yoram Rudy PMCID: PMC1458874 Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo Omid C. Farokhzad, Jianjun Cheng, Benjamin A. Teply, Ines Sherifi, Sangyong Jon, Philip W. Kantoff, Jerome P. Richie, and Robert Langer PMCID: PMC1458875 Bone marrow-derived cells fuse with normal and transformed intestinal stem cells Adnan Z. Rizvi, John R. Swain, Paige S. Davies, Alexis S. Bailey, Adria D. Decker, Holger Willenbring, Markus Grompe, William H. Fleming, and Melissa H. Wong PMCID: PMC1435365 Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells Barbara Uzonyi, Katharina Lötzer, Steffen Jahn, Cornelia Kramer, Markus Hildner, Ellen Bretschneider, Dörte Radke, Michael Beer, Rüdiger Vollandt, Jilly F. Evans, Colin D. Funk, and Andreas J. R. Habenicht PMCID: PMC1458877 Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin Piyali Dasgupta, Rebecca Kinkade, Bharat Joshi, Christina DeCook, Eric Haura, and Srikumar Chellappan PMCID: PMC1458878 Absence of the transcription factor CCAAT enhancer binding protein α results in loss of myeloid identity in bcr/abl-induced malignancy Katharina Wagner, Pu Zhang, Frank Rosenbauer, Bettina Drescher, Susumu Kobayashi, Hanna S. Radomska, Jeffery L. Kutok, D. Gary Gilliland, Jürgen Krauter, and Daniel G. Tenen PMCID: PMC1458879 Identification of small molecules that induce apoptosis in a Myc-dependent manner and inhibit Myc-driven transformation Hao Mo and Marie Henriksson PMCID: PMC1435363 Microbiology Transmissibility of cholera: In vivo-formed biofilms and their relationship to infectivity and persistence in the environment Shah M. Faruque, Kuntal Biswas, S. M. Nashir Udden, Qazi Shafi Ahmad, David A. Sack, G. Balakrish Nair, and John J. Mekalanos PMCID: PMC1458881 Phenolic lipid synthesis by type III polyketide synthases is essential for cyst formation in Azotobacter vinelandii Nobutaka Funa, Hiroki Ozawa, Aiko Hirata, and Sueharu Horinouchi PMCID: PMC1458882 Neuroscience From the Cover:
Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection Anke Witting, Lanfen Chen, Eiron Cudaback, Alex Straiker, Lisa Walter, Barry Rickman, Thomas Möller, Celia Brosnan, and Nephi Stella PMCID: PMC1458883 Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis Megan K. Mulligan, Igor Ponomarev, Robert J. Hitzemann, John K. Belknap, Boris Tabakoff, R. Adron Harris, John C. Crabbe, Yuri A. Blednov, Nicholas J. Grahame, Tamara J. Phillips, Deborah A. Finn, Paula L. Hoffman, Vishwanath R. Iyer, George F. Koob, and Susan E. Bergeson PMCID: PMC1458884 CD24 is expressed by myofiber synaptic nuclei and regulates synaptic transmission Marko Jevsek, Alexander Jaworski, Luis Polo-Parada, Natalie Kim, Jihua Fan, Lynn T. Landmesser, and Steven J. Burden PMCID: PMC1435367 mGluR2 acts through inhibitory Gα subunits to regulate transmission and long-term plasticity at hippocampal mossy fiber-CA3 synapses Russell E. Nicholls, Xiao-lei Zhang, Christopher P. Bailey, Bruce R. Conklin, Eric R. Kandel, and Patric K. Stanton PMCID: PMC1458886 Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1 Irene Yujnovsky, Jun Hirayama, Masao Doi, Emiliana Borrelli, and Paolo Sassone-Corsi PMCID: PMC1458887 Physiology Toll-like receptor 4 plays a crucial role in the immune–adrenal response to systemic inflammatory response syndrome Kai Zacharowski, Paula A. Zacharowski, Alexander Koch, Aida Baban, Nguyen Tran, Reinhard Berkels, Claudia Papewalis, Klaus Schulze-Osthoff, Pascal Knuefermann, Ulrich Zähringer, Ralf R. Schumann, Valeria Rettori, Samuel M. McCann, and Stefan R. Bornstein PMCID: PMC1458888 Plant Biology The tomato FT ortholog triggers systemic signals that regulate growth and flowering and substitute for diverse environmental stimuli Eliezer Lifschitz, Tamar Eviatar, Alexander Rozman, Akiva Shalit, Alexander Goldshmidt, Ziva Amsellem, John Paul Alvarez, and Yuval Eshed PMCID: PMC1458889 Phosphorylation and activation of PINOID by the phospholipid signaling kinase 3-phosphoinositide-dependent protein kinase 1 (PDK1) in Arabidopsis Hicham Zegzouti, Richard G. Anthony, Nadine Jahchan, László Bögre, and Sioux K. Christensen PMCID: PMC1458890 Corrections Correction for Lam et al., Human centromeric chromatin is a dynamic chromosomal domain that can spread over noncentromeric DNA PMCID: PMC1473159 Corrects: Ai Leen Lam, et al. Human centromeric chromatin is a dynamic chromosomal domain that can spread over noncentromeric DNA. Proc Natl Acad Sci U S A. 2006 March 14; 103(11): 4186–4191. Correction for Krogan et al., Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4 PMCID: PMC1458894 Corrects: Nevan J. Krogan, et al. Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4. Proc Natl Acad Sci U S A. 2004 September 14; 101(37): 13513–13518. Correction for Kulesekara et al., Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3′-5′)-cyclic-GMP in virulence Hemantha Kulasakara, Vincent Lee, Anja Brencic, Nicole Liberati, Jonathan Urbach, Sachiko Miyata, Daniel G. Lee, Alice N. Neely, Mamoru Hyodo, Yoshihiro Hayakawa, Frederick M. Ausubel, and Stephen Lory PMCID: PMC1473160 Corrects: Hemantha Kulesekara, et al. Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3′-5′)-cyclic-GMP in virulence. Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2839–2844. Correction for Li et al., Association of late-onset Alzheimer’s disease with genetic variation in multiple members of the GAPD gene family PMCID: PMC1458896 Corrects: Yonghong Li, et al. Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family. Proc Natl Acad Sci U S A. 2004 November 2; 101(44): 15688–15693. |
