| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2006 March 14; 103(11): 3945–3946. doi: 10.1073/iti1106103.PMCID: PMC1449621 Commentaries Big, bad hearts: From flies to man Fabrizio C. Serluca and Mark C. Fishman PMCID: PMC1449622 Barcoding helps biodiversity fly Edward Allen Herre PMCID: PMC1449623 MicroRNAs: New players in an old game Malavika Gupta and Gary Brewer PMCID: PMC1449624 There’s a GAP in the ENTH domain Brigitte Ritter and Peter S. McPherson PMCID: PMC1449625 Worming into the cell: Viral reproduction in Caenorhabditis elegans Shai Shaham PMCID: PMC1449626 Profile Profile of Robert D. Drennan Nick Zagorski PMCID: PMC1449627 Physical Sciences Applied Mathematics Global asymptotic coherence in discrete dynamical systems David J. D. Earn and Simon A. Levin PMCID: PMC1449629 Chemistry Design of natural killer T cell activators: Structure and function of a microbial glycosphingolipid bound to mouse CD1d Douglass Wu, Dirk M. Zajonc, Masakazu Fujio, Barbara A. Sullivan, Yuki Kinjo, Mitchell Kronenberg, Ian A. Wilson, and Chi-Huey Wong PMCID: PMC1449630 Gold nanoparticles-based protease assay Cristian Guarise, Lucia Pasquato, Vincenzo De Filippis, and Paolo Scrimin PMCID: PMC1449631 The time required for water attack at the phosphorus atom of simple phosphodiesters and of DNA Gottfried K. Schroeder, Chetan Lad, Paul Wyman, Nicholas H. Williams, and Richard Wolfenden PMCID: PMC1449644 Computer Sciences Discrete and continuous min-energy schedules for variable voltage processors Minming Li, Andrew C. Yao, and Frances F. Yao PMCID: PMC1449632 Environmental Sciences Global health benefits of mitigating ozone pollution with methane emission controls J. Jason West, Arlene M. Fiore, Larry W. Horowitz, and Denise L. Mauzerall PMCID: PMC1449633 Geophysics Stabilizing the Earth’s climate is not a losing game: Supporting evidence from public goods experiments Manfred Milinski, Dirk Semmann, Hans-Jürgen Krambeck, and Jochem Marotzke PMCID: PMC1449634 Physics Rules for biological regulation based on error minimization Guy Shinar, Erez Dekel, Tsvi Tlusty, and Uri Alon PMCID: PMC1389706 Highly designable phenotypes and mutational buffers emerge from a systematic mapping between network topology and dynamic output Yigal D. Nochomovitz and Hao Li PMCID: PMC1449667 Sustainability Science Global health benefits of mitigating ozone pollution with methane emission controls J. Jason West, Arlene M. Fiore, Larry W. Horowitz, and Denise L. Mauzerall PMCID: PMC1449633 Stabilizing the Earth’s climate is not a losing game: Supporting evidence from public goods experiments Manfred Milinski, Dirk Semmann, Hans-Jürgen Krambeck, and Jochem Marotzke PMCID: PMC1449634 Biological Sciences Applied Biological Sciences Engineered antibody Fc variants with enhanced effector function Greg A. Lazar, Wei Dang, Sher Karki, Omid Vafa, Judy S. Peng, Linus Hyun, Cheryl Chan, Helen S. Chung, Araz Eivazi, Sean C. Yoder, Jost Vielmetter, David F. Carmichael, Robert J. Hayes, and Bassil I. Dahiyat PMCID: PMC1389705 Severe acute respiratory syndrome diagnostics using a coronavirus protein microarray Heng Zhu, Shaohui Hu, Ghil Jona, Xiaowei Zhu, Nate Kreiswirth, Barbara M. Willey, Tony Mazzulli, Guozhen Liu, Qifeng Song, Peng Chen, Mark Cameron, Andrea Tyler, Jian Wang, Jie Wen, Weijun Chen, Susan Compton, and Michael Snyder PMCID: PMC1449637 Rapid, sequence-specific detection of unpurified PCR amplicons via a reusable, electrochemical sensor Rebecca Y. Lai, Eric T. Lagally, Sang-Ho Lee, H. T. Soh, Kevin W. Plaxco, and Alan J. Heeger PMCID: PMC1449638 Biochemistry Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation Hai Xu, Catherine Faber, Tomoaki Uchiki, James W. Fairman, Joseph Racca, and Chris Dealwis PMCID: PMC1389704 Structures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly Hai Xu, Catherine Faber, Tomoaki Uchiki, Joseph Racca, and Chris Dealwis PMCID: PMC1389703 From the Cover:
MicroRNAs direct rapid deadenylation of mRNA Ligang Wu, Jihua Fan, and Joel G. Belasco PMCID: PMC1449641 STIM1 has a plasma membrane role in the activation of store-operated Ca2+ channels Maria A. Spassova, Jonathan Soboloff, Li-Ping He, Wen Xu, Marie A. Dziadek, and Donald L. Gill PMCID: PMC1449642 Structural basis of hepatocyte growth factor/scatter factor and MET signalling Ermanno Gherardi, Sara Sandin, Maxim V. Petoukhov, John Finch, Mark E. Youles, Lars-Göran Öfverstedt, Ricardo N. Miguel, Tom L. Blundell, George F. Vande Woude, Ulf Skoglund, and Dmitri I. Svergun PMCID: PMC1449643 The time required for water attack at the phosphorus atom of simple phosphodiesters and of DNA Gottfried K. Schroeder, Chetan Lad, Paul Wyman, Nicholas H. Williams, and Richard Wolfenden PMCID: PMC1449644 Repair of DNA–polypeptide crosslinks by human excision nuclease Joyce T. Reardon and Aziz Sancar PMCID: PMC1449645 Sleeping Beauty transposase modulates cell-cycle progression through interaction with Miz-1 Oliver Walisko, Zsuzsanna Izsvák, Kornélia Szabó, Christopher D. Kaufman, Steffi Herold, and Zoltán Ivics PMCID: PMC1449646 BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates Leonard Wu, Csanad Z. Bachrati, Jiongwen Ou, Chang Xu, Jinhu Yin, Michael Chang, Weidong Wang, Lei Li, Grant W. Brown, and Ian D. Hickson PMCID: PMC1449647 Biophysics The 3D profile method for identifying fibril-forming segments of proteins Michael J. Thompson, Stuart A. Sievers, John Karanicolas, Magdalena I. Ivanova, David Baker, and David Eisenberg PMCID: PMC1449648 A systematic screen of β2-microglobulin and insulin for amyloid-like segments Magdalena I. Ivanova, Michael J. Thompson, and David Eisenberg PMCID: PMC1449649 Identification of the minimal protein-folding nucleus through loop-entropy perturbations Magnus O. Lindberg, Ellinor Haglund, Isaac A. Hubner, Eugene I. Shakhnovich, and Mikael Oliveberg PMCID: PMC1449650 A dark yellow fluorescent protein (YFP)-based Resonance Energy-Accepting Chromoprotein (REACh) for Förster resonance energy transfer with GFP Sundar Ganesan, Simon M. Ameer-beg, Tony T. C. Ng, Borivoj Vojnovic, and Fred S. Wouters PMCID: PMC1449651 The folding energy landscape of apoflavodoxin is rugged: Hydrogen exchange reveals nonproductive misfolded intermediates Yves J. M. Bollen, Monique B. Kamphuis, and Carlo P. M. van Mierlo PMCID: PMC1449652 Insights into excited-state and isomerization dynamics of bacteriorhodopsin from ultrafast transient UV absorption S. Schenkl, F. van Mourik, N. Friedman, M. Sheves, R. Schlesinger, S. Haacke, and M. Chergui PMCID: PMC1449653 Strict rules determine arrangements of strands in sandwich proteins A. E. Kister, A. S. Fokas, T. S. Papatheodorou, and I. M. Gelfand PMCID: PMC1449654 UV causation of melanoma in Xiphophorus is dominated by melanin photosensitized oxidant production Simon R. Wood, Marianne Berwick, Ronald D. Ley, Ronald B. Walter, Richard B. Setlow, and Graham S. Timmins PMCID: PMC1449655 Cell Biology From the Cover:
Epsin N-terminal homology domains perform an essential function regulating Cdc42 through binding Cdc42 GTPase-activating proteins Rubén C. Aguilar, Silvia A. Longhi, Jonathan D. Shaw, Lan-Yu Yeh, Sean Kim, Arne Schön, Ernesto Freire, Ariel Hsu, William K. McCormick, Hadiya A. Watson, and Beverly Wendland PMCID: PMC1449656 Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1 Wei-Ming Chien, Stuart Rabin, Everardo Macias, Paula L. Miliani de Marval, Kendra Garrison, Jason Orthel, Marcelo Rodriguez-Puebla, and Matthew L. Fero PMCID: PMC1449657 The dependence receptor DCC requires lipid raft localization for cell death signaling Céline Furne, Véronique Corset, Zoltán Hérincs, Nathalie Cahuzac, Anne-Odile Hueber, and Patrick Mehlen PMCID: PMC1449658 Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2 Hong Liu, Derek C. Radisky, Celeste M. Nelson, Hui Zhang, Jimmie E. Fata, Richard A. Roth, and Mina J. Bissell PMCID: PMC1390746 Developmental Biology Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2 Shun-ichiro Matsumoto, Chihiro Yamazaki, Koh-hei Masumoto, Mamoru Nagano, Masanori Naito, Takatoshi Soga, Hideki Hiyama, Mitsuyuki Matsumoto, Jun Takasaki, Masazumi Kamohara, Ayako Matsuo, Hiroyuki Ishii, Masato Kobori, Masao Katoh, Hitoshi Matsushime, Kiyoshi Furuichi, and Yasufumi Shigeyoshi PMCID: PMC1449660 Circadian time-keeping during early stages of development Limor Ziv and Yoav Gothilf PMCID: PMC1449661 Ecology Cannibal crickets on a forced march for protein and salt Stephen J. Simpson, Gregory A. Sword, Patrick D. Lorch, and Iain D. Couzin PMCID: PMC1449662 Latent extinction risk and the future battlegrounds of mammal conservation Marcel Cardillo, Georgina M. Mace, John L. Gittleman, and Andy Purvis PMCID: PMC1449663 Evolution Gene evolution at the ends of wheat chromosomes Deven R. See, Steven Brooks, James C. Nelson, Gina Brown-Guedira, Bernd Friebe, and Bikram S. Gill PMCID: PMC1449664 Haptoglobin, a hemoglobin-binding plasma protein, is present in bony fish and mammals but not in frog and chicken Krzysztof B. Wicher and Erik Fries PMCID: PMC1449665 Genetics From the Cover:
Restriction of vaccinia virus replication by a ced-3 and ced-4-dependent pathway in Caenorhabditis elegans Wan-Hsin Liu, Yi-Ling Lin, Jia-Pey Wang, Willisa Liou, Roger F. Hou, Yi-Chun Wu, and Ching-Len Liao PMCID: PMC1389701 Highly designable phenotypes and mutational buffers emerge from a systematic mapping between network topology and dynamic output Yigal D. Nochomovitz and Hao Li PMCID: PMC1449667 Human centromeric chromatin is a dynamic chromosomal domain that can spread over noncentromeric DNA Ai Leen Lam, Christopher D. Boivin, Caitlin F. Bonney, M. Katharine Rudd, and Beth A. Sullivan PMCID: PMC1449668 Global identification of noncoding RNAs in Saccharomyces cerevisiae by modulating an essential RNA processing pathway Manoj Pratim Samanta, Waraporn Tongprasit, Himanshu Sethi, Chen-Shan Chin, and Viktor Stolc PMCID: PMC1389707 Engineering RNA interference-based resistance to dengue virus type 2 in genetically modified Aedes aegypti Alexander W. E. Franz, Irma Sanchez-Vargas, Zach N. Adelman, Carol D. Blair, Barry J. Beaty, Anthony A. James, and Ken E. Olson PMCID: PMC1449670 Immunology Design of natural killer T cell activators: Structure and function of a microbial glycosphingolipid bound to mouse CD1d Douglass Wu, Dirk M. Zajonc, Masakazu Fujio, Barbara A. Sullivan, Yuki Kinjo, Mitchell Kronenberg, Ian A. Wilson, and Chi-Huey Wong PMCID: PMC1449630 Evidence for the ancient origin of the NF-κB/IκB cascade: Its archaic role in pathogen infection and immunity Xiao Wei Wang, Nguan Soon Tan, Bow Ho, and Jeak Ling Ding PMCID: PMC1449671 Selective potentiation of Stat-dependent gene expression by collaborator of Stat6 (CoaSt6), a transcriptional cofactor Shreevrat Goenka and Mark Boothby PMCID: PMC1449672 Medical Sciences Interruption of tumor dormancy by a transient angiogenic burst within the tumor microenvironment Stefano Indraccolo, Laura Stievano, Sonia Minuzzo, Valeria Tosello, Giovanni Esposito, Erich Piovan, Rita Zamarchi, Luigi Chieco-Bianchi, and Alberto Amadori PMCID: PMC1449673 Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity Shubha V. Y. Raju, Meizi Zheng, Karl H. Schuleri, Alexander C. Phan, Djahida Bedja, Roberto M. Saraiva, Omer Yiginer, Koenraad Vandegaer, Kathleen L. Gabrielson, Christopher P. O’Donnell, Dan E. Berkowitz, Lili A. Barouch, and Joshua M. Hare PMCID: PMC1449674 Cortistatin, an antiinflammatory peptide with therapeutic action in inflammatory bowel disease Elena Gonzalez-Rey, Nieves Varela, Amir F. Sheibanie, Alejo Chorny, Doina Ganea, and Mario Delgado PMCID: PMC1449675 Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides Andreas Schirmer, Jonathan Kennedy, Sumati Murli, Ralph Reid, and Daniel V. Santi PMCID: PMC1449676 Identification of proangiogenic genes and pathways by high-throughput functional genomics: TBK1 and the IRF3 pathway Christian Korherr, Hendrik Gille, Rolf Schäfer, Kerstin Koenig-Hoffmann, Johan Dixelius, Kristi A. Egland, Ira Pastan, and Ulrich Brinkmann PMCID: PMC1449677 From the Cover:
Pharmacological promotion of inclusion formation: A therapeutic approach for Huntington’s and Parkinson’s diseases Ruth A. Bodner, Tiago Fleming Outeiro, Stephen Altmann, Michele M. Maxwell, Stephanie H. Cho, Bradley T. Hyman, Pamela J. McLean, Anne B. Young, David E. Housman, and Aleksey G. Kazantsev PMCID: PMC1449678 Microbiology From the Cover:
Interaction between the membrane protein of a pathogen and insect microfilament complex determines insect-vector specificity Shiho Suzuki, Kenro Oshima, Shigeyuki Kakizawa, Ryo Arashida, Hee-Young Jung, Yasuyuki Yamaji, Hisashi Nishigawa, Masashi Ugaki, and Shigetou Namba PMCID: PMC1449679 A sulfated metabolite produced by stf3 negatively regulates the virulence of Mycobacterium tuberculosis Joseph D. Mougous, Ryan H. Senaratne, Christopher J. Petzold, Madhulika Jain, Dong H. Lee, Michael W. Schelle, Michael D. Leavell, Jeffery S. Cox, Julie A. Leary, Lee W. Riley, and Carolyn R. Bertozzi PMCID: PMC1449680 Neuroscience Presynaptic and postsynaptic Ca2+ and CamKII contribute to long-term potentiation at synapses between individual CA3 neurons Fang-Min Lu and Robert D. Hawkins PMCID: PMC1449681 Identification of a genetic cluster influencing memory performance and hippocampal activity in humans Dominique J.-F. de Quervain and Andreas Papassotiropoulos PMCID: PMC1390747 Imidazenil and diazepam increase locomotor activity in mice exposed to protracted social isolation Graziano Pinna, Roberto C. Agis-Balboa, Adrian Zhubi, Kinzo Matsumoto, Dennis R. Grayson, Erminio Costa, and Alessandro Guidotti PMCID: PMC1449683 G protein βγ-subunits activated by serotonin mediate presynaptic inhibition by regulating vesicle fusion properties Huzefa Photowala, Trillium Blackmer, Eric Schwartz, Heidi E. Hamm, and Simon Alford PMCID: PMC1449684 Relative spike timing in pairs of hippocampal neurons distinguishes the beginning and end of journeys Matthew L. Shapiro and Janina Ferbinteanu PMCID: PMC1449685 Inadvertent social information and the avoidance of parasitized male mice: A role for oxytocin Martin Kavaliers, Elena Choleris, Anders Ågmo, W. John Braun, Douglas D. Colwell, Louis J. Muglia, Sonoko Ogawa, and Donald W. Pfaff PMCID: PMC1449686 Pharmacology Fatty acid transduction of nitric oxide signaling: Nitrolinoleic acid potently activates endothelial heme oxygenase 1 expression Marcienne M. Wright, Francisco J. Schopfer, Paul R. S. Baker, Vijay Vidyasagar, Pam Powell, Phil Chumley, Karen E. Iles, Bruce A. Freeman, and Anupam Agarwal PMCID: PMC1449687 Physiology Orphaned ryanodine receptors in the failing heart Long-Sheng Song, Eric A. Sobie, Stacey McCulle, W. J. Lederer, C. William Balke, and Heping Cheng PMCID: PMC1449688 Role of calcium in the regulation of mechanical power in insect flight Shefa Gordon and Michael H. Dickinson PMCID: PMC1449689 Metabotropic Ca2+ channel-induced Ca2+ release and ATP-dependent facilitation of arterial myocyte contraction Alberto del Valle-Rodríguez, Eva Calderón, Myriam Ruiz, Antonio Ordoñez, José López-Barneo, and Juan Ureña PMCID: PMC1449690 Population Biology Global asymptotic coherence in discrete dynamical systems David J. D. Earn and Simon A. Levin PMCID: PMC1449629 Psychology Pathophysiological processes underlying emotional triggering of acute cardiac events Philip C. Strike, Kesson Magid, Daisy L. Whitehead, Lena Brydon, Mimi R. Bhattacharyya, and Andrew Steptoe PMCID: PMC1449691 Social Sciences Anthropology INAUGURAL ARTICLE by a Recently Elected Academy Member: Patterned variation in prehistoric chiefdoms Robert D. Drennan and Christian E. Peterson PMCID: PMC1449628 Corrections Correction for Mello and Tu, An allosteric model for heterogeneous receptor complexes: Understanding bacterial chemotaxis responses to multiple stimuli PMCID: PMC1449692 Corrects: Bernardo A. Mello, et al. An allosteric model for heterogeneous receptor complexes: Understanding bacterial chemotaxis responses to multiple stimuli. Proc Natl Acad Sci U S A. 2005 November 29; 102(48): 17354–17359. Correction for Auerbach et al., Mutagenic specificity of endogenously generated abasic sites in Saccharomyces cerevisiae chromosomal DNA PMCID: PMC1449693 Corrects: Paul Auerbach, et al. Mutagenic specificity of endogenously generated abasic sites in Saccharomyces cerevisiae chromosomal DNA. Proc Natl Acad Sci U S A. 2005 December 6; 102(49): 17711–17716. Correction for Vitetta et al., A pilot clinical trial of a recombinant ricin vaccine in normal humans PMCID: PMC1449694 Corrects: Ellen S. Vitetta, et al. A pilot clinical trial of a recombinant ricin vaccine in normal humans. Proc Natl Acad Sci U S A. 2006 February 14; 103(7): 2268–2273. Correction for Honegger et al., Regulation of sodium-proton exchanger isoform 3 (NHE3) by PKA and exchange protein directly activated by cAMP (EPAC) PMCID: PMC1449695 Corrects: Katharina J. Honegger, et al. Regulation of sodium-proton exchanger isoform 3 (NHE3) by PKA and exchange protein directly activated by cAMP (EPAC). Proc Natl Acad Sci U S A. 2006 January 17; 103(3): 803–808. Retraction Retraction for Fernández et al., Packing defects as selectivity switches for drug-based protein inhibitors Nicholas R. Cozzarelli PMCID: PMC1449696 Retracts: Ariel Fernández, et al. Packing defects as selectivity switches for drug-based protein inhibitors. Proc Natl Acad Sci U S A. 2006 January 10; 103(2): 323–328. |
