| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2006 February 28; 103(9): 3009–3010. doi: 10.1073/iti0906103.PMCID: PMC1413951 Commentaries Amphibian diversity: Decimation by disease Pieter T. J. Johnson PMCID: PMC1413947 Fighting anthrax with flies Nikolaos Giagtzoglou and Hugo J. Bellen PMCID: PMC1413949 Circadian organization in the real world Michael Menaker PMCID: PMC1413948 Profiles Profile of Huda Y. Zoghbi Regina Nuzzo PMCID: PMC1413894 Profile of David H. Baker Nick Zagorski PMCID: PMC1413950 Physical Sciences Applied Physical Sciences Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers Ravi Singh, Davide Pantarotto, Lara Lacerda, Giorgia Pastorin, Cédric Klumpp, Maurizio Prato, Alberto Bianco, and Kostas Kostarelos PMCID: PMC1413890 Chemistry Magnetic superlattices and their nanoscale phase transition effects Jinwoo Cheon, Jong-Il Park, Jin-sil Choi, Young-wook Jun, Sehun Kim, Min Gyu Kim, Young-Min Kim, and Youn Joong Kim PMCID: PMC1413888 Self-assembly of synthetic collagen triple helices Frank W. Kotch and Ronald T. Raines PMCID: PMC1413887 Cooperativity in the self-assembly of porphyrin ladders Amaya Camara-Campos, Christopher A. Hunter, and Salvador Tomas PMCID: PMC1413879 Structure and mechanism of mouse cysteine dioxygenase Jason G. McCoy, Lucas J. Bailey, Eduard Bitto, Craig A. Bingman, David J. Aceti, Brian G. Fox, and George N. Phillips, Jr. PMCID: PMC1413891 Environmental Sciences-PS From the Cover:
The effect of climate variation on agro-pastoral production in Africa Leif Christian Stige, Jørn Stave, Kung-Sik Chan, Lorenzo Ciannelli, Nathalie Pettorelli, Michael Glantz, Hans R. Herren, and Nils Chr. Stenseth PMCID: PMC1413945 Geophysics Equation of state of the postperovskite phase synthesized from a natural (Mg,Fe)SiO3 orthopyroxene Sean R. Shieh, Thomas S. Duffy, Atsushi Kubo, Guoyin Shen, Vitali B. Prakapenka, Nagayoshi Sata, Kei Hirose, and Yasuo Ohishi PMCID: PMC1413868 Physics Depth sectioning with the aberration-corrected scanning transmission electron microscope Albina Y. Borisevich, Andrew R. Lupini, and Stephen J. Pennycook PMCID: PMC1413870 Biological Sciences Agricultural Sciences From the Cover:
The effect of climate variation on agro-pastoral production in Africa Leif Christian Stige, Jørn Stave, Kung-Sik Chan, Lorenzo Ciannelli, Nathalie Pettorelli, Michael Glantz, Hans R. Herren, and Nils Chr. Stenseth PMCID: PMC1413945 Biochemistry Opsin is present as dimers in COS1 cells: Identification of amino acids at the dimeric interface Parvathi Kota, Philip J. Reeves, Uttam L. RajBhandary, and H. Gobind Khorana PMCID: PMC1413904 Rhodopsin self-associates in asolectin liposomes Steven E. Mansoor, Krzysztof Palczewski, and David L. Farrens PMCID: PMC1413906 The molecular architecture of the metalloprotease FtsH Christoph Bieniossek, Thomas Schalch, Mario Bumann, Markus Meister, Reto Meier, and Ulrich Baumann PMCID: PMC1413944 Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis Ting-Wan Lin, Melrose M. Melgar, Daniel Kurth, S. Joshua Swamidass, John Purdon, Teresa Tseng, Gabriela Gago, Pierre Baldi, Hugo Gramajo, and Shiou-Chuan Tsai PMCID: PMC1413898 From the Cover:
Aminoacyl-transferases and the N-end rule pathway of prokaryotic/eukaryotic specificity in a human pathogen Emmanuelle Graciet, Rong-Gui Hu, Konstantin Piatkov, Joon Haeng Rhee, Erich M. Schwarz, and Alexander Varshavsky PMCID: PMC1413915 Structure and mechanism of mouse cysteine dioxygenase Jason G. McCoy, Lucas J. Bailey, Eduard Bitto, Craig A. Bingman, David J. Aceti, Brian G. Fox, and George N. Phillips, Jr. PMCID: PMC1413891 Chromatin remodeling by nucleosome disassembly in vitro Yahli Lorch, Barbara Maier-Davis, and Roger D. Kornberg PMCID: PMC1413907 Combined top-down and bottom-up proteomics identifies a phosphorylation site in stem–loop-binding proteins that contributes to high-affinity RNA binding Christoph H. Borchers, Roopa Thapar, Evgeniy V. Petrotchenko, Matthew P. Torres, J. Paul Speir, Michael Easterling, Zbigniew Dominski, and William F. Marzluff PMCID: PMC1413926 Ligand-specific allosteric regulation of coactivator functions of androgen receptor in prostate cancer cells Sung Hee Baek, Kenneth A. Ohgi, Charles A. Nelson, Derek Welsbie, Charlie Chen, Charles L. Sawyers, David W. Rose, and Michael G. Rosenfeld PMCID: PMC1413901 Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor Tilman M. Hackeng, Kristin M. Seré, Guido Tans, and Jan Rosing PMCID: PMC1413864 TNFα induces ABCA1 through NF-κB in macrophages and in phagocytes ingesting apoptotic cells Marie-Christine Gerbod-Giannone, Yankun Li, Adriaan Holleboom, Seongah Han, Li-Chung Hsu, Ira Tabas, and Alan R. Tall PMCID: PMC1413897 Myo1c binds tightly and specifically to phosphatidylinositol 4,5-bisphosphate and inositol 1,4,5-trisphosphate David E. Hokanson and E. Michael Ostap PMCID: PMC1413866 Biophysics Self-assembly of synthetic collagen triple helices Frank W. Kotch and Ronald T. Raines PMCID: PMC1413887 Overcoming photodamage in second-harmonic generation microscopy: Real-time optical recording of neuronal action potentials L. Sacconi, D. A. Dombeck, and W. W. Webb PMCID: PMC1413939 Base-tetrad swapping results in dimerization of RNA quadruplexes: Implications for formation of the i-motif RNA octaplex Baocheng Pan, Ke Shi, and Muttaiya Sundaralingam PMCID: PMC1413875 Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex Taro Tamada, Eijiro Honjo, Yoshitake Maeda, Tomoyuki Okamoto, Matsujiro Ishibashi, Masao Tokunaga, and Ryota Kuroki PMCID: PMC1413920 Shaping up the protein folding funnel by local interaction: Lesson from a structure prediction study George Chikenji, Yoshimi Fujitsuka, and Shoji Takada PMCID: PMC1413881 Common dynamical signatures of familial amyotrophic lateral sclerosis-associated structurally diverse Cu, Zn superoxide dismutase mutants Sagar D. Khare and Nikolay V. Dokholyan PMCID: PMC1413921 Cell Biology An efficient rapid system for profiling the cellular activities of molecular libraries Jonathan S. Melnick, Jeff Janes, Sungjoon Kim, Jim Y. Chang, Daniel G. Sipes, Drew Gunderson, Laura Jarnes, Jason T. Matzen, Michael E. Garcia, Tami L. Hood, Ronak Beigi, Gang Xia, Richard A. Harig, Hayk Asatryan, S. Frank Yan, Yingyao Zhou, Xiang-Ju Gu, Alham Saadat, Vicki Zhou, Frederick J. King, Christopher M. Shaw, Andrew I. Su, Robert Downs, Nathanael S. Gray, Peter G. Schultz, Markus Warmuth, and Jeremy S. Caldwell PMCID: PMC1413928 Proteomic analysis of adaptor protein 1A coats selectively assembled on liposomes Thorsten Baust, Cornelia Czupalla, Eberhard Krause, Line Bourel-Bonnet, and Bernard Hoflack PMCID: PMC1413908 Ecology From The Cover:
Emerging infectious disease and the loss of biodiversity in a Neotropical amphibian community Karen R. Lips, Forrest Brem, Roberto Brenes, John D. Reeve, Ross A. Alford, Jamie Voyles, Cynthia Carey, Lauren Livo, Allan P. Pessier, and James P. Collins PMCID: PMC1413869 Fishing through marine food webs Timothy E. Essington, Anne H. Beaudreau, and John Wiedenmann PMCID: PMC1413903 Ecological functions of tetrodotoxin in a deadly polyclad flatworm Raphael Ritson-Williams, Mari Yotsu-Yamashita, and Valerie J. Paul PMCID: PMC1413867 Evolution Lamprey type II collagen and Sox9 reveal an ancient origin of the vertebrate collagenous skeleton GuangJun Zhang, Michael M. Miyamoto, and Martin J. Cohn PMCID: PMC1413883 Phylogenetic comparisons suggest that distance from the locus control region guides developmental expression of primate β-type globin genes Robert M. Johnson, Tom Prychitko, Deborah Gumucio, Derek E. Wildman, Monica Uddin, and Morris Goodman PMCID: PMC1413942 Heterogeneous but conserved natural killer receptor gene complexes in four major orders of mammals Li Hao, Jan Klein, and Masatoshi Nei PMCID: PMC1413923 An optimal brain can be composed of conflicting agents Adi Livnat and Nicholas Pippenger PMCID: PMC1413902 Evolution of the mammalian placenta revealed by phylogenetic analysis Derek E. Wildman, Caoyi Chen, Offer Erez, Lawrence I. Grossman, Morris Goodman, and Roberto Romero PMCID: PMC1413940 Ecological divergence exhibits consistently positive associations with reproductive isolation across disparate taxa Daniel J. Funk, Patrik Nosil, and William J. Etges PMCID: PMC1413886 Spatial heterogeneity, predator cognition, and the evolution of color polymorphism in virtual prey Alan B. Bond and Alan C. Kamil PMCID: PMC1413896 Evolutionary fate of retroposed gene copies in the human genome Nicolas Vinckenbosch, Isabelle Dupanloup, and Henrik Kaessmann PMCID: PMC1413932 Evolutionary dynamics of social dilemmas in structured heterogeneous populations F. C. Santos, J. M. Pacheco, and Tom Lenaerts PMCID: PMC1413882 Genetics Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development Shunbin Xiong, Carolyn S. Van Pelt, Ana C. Elizondo-Fraire, Geng Liu, and Guillermina Lozano PMCID: PMC1413885 Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo Sarah Francoz, Pascal Froment, Sven Bogaerts, Sarah De Clercq, Marion Maetens, Gilles Doumont, Eric Bellefroid, and Jean-Christophe Marine PMCID: PMC1413884 High frequency of centromere inactivation resulting in stable dicentric chromosomes of maize Fangpu Han, Jonathan C. Lamb, and James A. Birchler PMCID: PMC1413895 From The Cover:
Anthrax lethal factor and edema factor act on conserved targets in
Drosophila Annabel Guichard, Jin Mo Park, Beatriz Cruz-Moreno, Michael Karin, and Ethan Bier PMCID: PMC1413899 Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson–Gilford progeria syndrome Renee Varga, Maria Eriksson, Michael R. Erdos, Michelle Olive, Ingrid Harten, Frank Kolodgie, Brian C. Capell, Jun Cheng, Dina Faddah, Stacie Perkins, Hedwig Avallone, Hong San, Xuan Qu, Santhi Ganesh, Leslie B. Gordon, Renu Virmani, Thomas N. Wight, Elizabeth G. Nabel, and Francis S. Collins PMCID: PMC1413943 Negative epistasis between natural variants of the Saccharomyces cerevisiae MLH1 and PMS1 genes results in a defect in mismatch repair Julie Akiko Heck, Juan Lucas Argueso, Zekeriyya Gemici, Richard Guy Reeves, Ann Bernard, Charles F. Aquadro, and Eric Alani PMCID: PMC1413905 Accumulation of unstable promoter-associated transcripts upon loss of the nuclear exosome subunit Rrp6p in Saccharomyces cerevisiae Carrie Anne Davis and Manuel Ares, Jr. PMCID: PMC1413877 RNA polymerase II subunit Rpb9 is important for transcriptional fidelity in vivo Nicole K. Nesser, David O. Peterson, and Diane K. Hawley PMCID: PMC1413937 Immunology Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells Ashish Banerjee, Raffi Gugasyan, Martin McMahon, and Steve Gerondakis PMCID: PMC1413910 A short isoform of NOD2/CARD15, NOD2-S, is an endogenous inhibitor of NOD2/receptor-interacting protein kinase 2-induced signaling pathways Philip Rosenstiel, Klaus Huse, Andreas Till, Jochen Hampe, Stephan Hellmig, Christian Sina, Susanne Billmann, Oliver von Kampen, Georg H. Waetzig, Matthias Platzer, Dirk Seegert, and Stefan Schreiber PMCID: PMC1413865 Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes Simon P. Graham, Roger Pellé, Yoshikazu Honda, Duncan M. Mwangi, Nyerhovwo J. Tonukari, Mat Yamage, E. Jane Glew, Etienne P. de Villiers, Trushar Shah, Richard Bishop, Evelyne Abuya, Elias Awino, James Gachanja, Anthony E. Luyai, Ferdinand Mbwika, Anthony M. Muthiani, David M. Ndegwa, Moses Njahira, John K. Nyanjui, Fredrick O. Onono, Julius Osaso, Rosemary M. Saya, Claude Wildmann, Claire M. Fraser, Ian Maudlin, Malcolm J. Gardner, Subhash P. Morzaria, Sheena Loosmore, Sarah C. Gilbert, Jean-Christophe Audonnet, Pierre van der Bruggen, Vishvanath Nene, and Evans L. N. Taracha PMCID: PMC1413922 Involvement of a tissue-specific autoantibody in skin disorders of murine systemic lupus erythematosus and autoinflammatory diseases Hiroyuki Nishimura and Jack L. Strominger PMCID: PMC1413900 IL-32, a proinflammatory cytokine in rheumatoid arthritis Leo A. B. Joosten, Mihai G. Netea, Soo-Hyun Kim, Do-Young Yoon, Birgitte Oppers-Walgreen, Timothy R. D. Radstake, Pilar Barrera, Fons A. J. van de Loo, Charles A. Dinarello, and Wim B. van den Berg PMCID: PMC1413916 Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells Chance John Luckey, Deepta Bhattacharya, Ananda W. Goldrath, Irving L. Weissman, Christophe Benoist, and Diane Mathis PMCID: PMC1413911 53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis Julio C. Morales, Sonia Franco, Michael M. Murphy, Craig H. Bassing, Kevin D. Mills, Melissa M. Adams, Nicole C. Walsh, John P. Manis, George Z. Rassidakis, Frederick W. Alt, and Phillip B. Carpenter PMCID: PMC1413919 Proteinase 3 is an IL-32 binding protein Daniela Novick, Menachem Rubinstein, Tania Azam, Aharon Rabinkov, Charles A. Dinarello, and Soo-Hyun Kim PMCID: PMC1413913 Wnt signaling in the thymus is regulated by differential expression of intracellular signaling molecules Floor Weerkamp, Miranda R. M. Baert, Brigitta A. E. Naber, Esther E. L. Koster, Edwin F. E. de Haas, Kondala R. Atkuri, Jacques J. M. van Dongen, Leonard A. Herzenberg, and Frank J. T. Staal PMCID: PMC1413930 Monovalent ligation of the B cell receptor induces receptor activation but fails to promote antigen presentation You-Me Kim, Jennifer Yi-Jiun Pan, Gregory A. Korbel, Victor Peperzak, Marianne Boes, and Hidde L. Ploegh PMCID: PMC1413933 Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion Lisa A. Spencer, Rossana C. N. Melo, Sandra A. C. Perez, Staci P. Bafford, Ann M. Dvorak, and Peter F. Weller PMCID: PMC1413889 Medical Sciences Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling Jean-Pierre Bourquin, Aravind Subramanian, Claudia Langebrake, Dirk Reinhardt, Olivier Bernard, Paola Ballerini, André Baruchel, Hélène Cavé, Nicole Dastugue, Henrik Hasle, Gertjan L. Kaspers, Michel Lessard, Lucienne Michaux, Paresh Vyas, Elisabeth van Wering, Christian M. Zwaan, Todd R. Golub, and Stuart H. Orkin PMCID: PMC1413912 Functional analyses of GB virus B p13 protein: Development of a recombinant GB virus B hepatitis virus with a p7 protein Shingo Takikawa, Ronald E. Engle, Suzanne U. Emerson, Robert H. Purcell, Marisa St. Claire, and Jens Bukh PMCID: PMC1413929 Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors Akash Nanda, Baktiar Karim, Zhongsheng Peng, Guosheng Liu, Weiping Qiu, Christine Gan, Bert Vogelstein, Brad St. Croix, Kenneth W. Kinzler, and David L. Huso PMCID: PMC1413931 Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers Ravi Singh, Davide Pantarotto, Lara Lacerda, Giorgia Pastorin, Cédric Klumpp, Maurizio Prato, Alberto Bianco, and Kostas Kostarelos PMCID: PMC1413890 Microbiology Gene expression patterns in dendritic cells infected with measles virus compared with other pathogens Michael J. Zilliox, Giovanni Parmigiani, and Diane E. Griffin PMCID: PMC1413941 The Vif and Vpr accessory proteins independently cause HIV-1-induced T cell cytopathicity and cell cycle arrest Keiko Sakai, Joseph Dimas, and Michael J. Lenardo PMCID: PMC1413893 Identification of a domain in Yersinia virulence factor YadA that is crucial for extracellular matrix-specific cell adhesion and uptake Tanja Heise and Petra Dersch PMCID: PMC1413876 Neuroscience Amyloid-β peptide binds with heme to form a peroxidase: Relationship to the cytopathologies of Alzheimer’s disease Hani Atamna and Kathleen Boyle PMCID: PMC1413946 A cerebellar model for predictive motor control tested in a brain-based device Jeffrey L. McKinstry, Gerald M. Edelman, and Jeffrey L. Krichmar PMCID: PMC1413924 From the Cover:
Impact of behavior on central and peripheral circadian clocks in the common vole Microtus arvalis, a mammal with ultradian rhythms Daan R. van der Veen, Nguyet Le Minh, Pascal Gos, Milica Arneric, Menno P. Gerkema, and Ueli Schibler PMCID: PMC1413878 Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens Ko-Woon Lee, Yong Kim, Amie M. Kim, Kathryn Helmin, Angus C. Nairn, and Paul Greengard PMCID: PMC1413917 Mutant Huntingtin: Nuclear translocation and cytotoxicity mediated by GAPDH Byoung-Il Bae, Makoto R. Hara, Matthew B. Cascio, Cheryl L. Wellington, Michael R. Hayden, Christopher A. Ross, Hyo Chol Ha, Xiao-Jiang Li, Solomon H. Snyder, and Akira Sawa PMCID: PMC1413934 AMPA receptor downscaling at the onset of Alzheimer’s disease pathology in double knockin mice Eric H. Chang, Mary J. Savage, Dorothy G. Flood, Justin M. Thomas, Robert B. Levy, Veeravan Mahadomrongkul, Tomoaki Shirao, Chiye Aoki, and Patricio T. Huerta PMCID: PMC1413872 Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis Andrew D. Steele, Jason G. Emsley, P. Hande Özdinler, Susan Lindquist, and Jeffrey D. Macklis PMCID: PMC1413927 Inhibition of a background potassium channel by Gq protein α-subunits Xiangdong Chen, Edmund M. Talley, Nitin Patel, Ana Gomis, William E. McIntire, Biwei Dong, Félix Viana, James C. Garrison, and Douglas A. Bayliss PMCID: PMC1413874 Directly reactivated, but not indirectly reactivated, memories undergo reconsolidation in the amygdala Jacek D ![[e ogonek]](corehtml/pmc/pmcents/eogon.gif) biec, Valérie Doyère, Karim Nader, and Joseph E. LeDoux PMCID: PMC1413871 Pharmacology Cyclic GMP-independent mechanisms contribute to the inhibition of platelet adhesion by nitric oxide donor: A role for α-actinin nitration Sisi Marcondes, Marcia H. M. Cardoso, Rafael P. Morganti, Sara M. Thomazzi, Sergio Lilla, Ferid Murad, Gilberto De Nucci, and Edson Antunes PMCID: PMC1413892 Physiology Alternatively spliced neuronal nitric oxide synthase mediates penile erection K. Joseph Hurt, Sena F. Sezen, Hunter C. Champion, Julie K. Crone, Michael A. Palese, Paul L. Huang, Akira Sawa, Xiaojiang Luo, Biljana Musicki, Solomon H. Snyder, and Arthur L. Burnett PMCID: PMC1413936 PPARδ regulates glucose metabolism and insulin sensitivity Chih-Hao Lee, Peter Olson, Andrea Hevener, Isaac Mehl, Ling-Wa Chong, Jerrold M. Olefsky, Frank J. Gonzalez, Jungyeob Ham, Heonjoong Kang, Jeffrey M. Peters, and Ronald M. Evans PMCID: PMC1413918 Differential effects of aging on fluid intake in response to hypovolemia, hypertonicity, and hormonal stimuli in Munich Wistar rats M. J. McKinley, D. A. Denton, C. J. Thomas, R. L. Woods, and M. L. Mathai PMCID: PMC1413909 Analysis of calstabin2 (FKBP12.6)–ryanodine receptor interactions: Rescue of heart failure by calstabin2 in mice Fannie Huang, Jian Shan, Steven Reiken, Xander H. T. Wehrens, and Andrew R. Marks PMCID: PMC1413925 Vital functions of corticotropin-releasing factor (CRF) pathways in maintenance and regulation of energy homeostasis Kendall M. Carlin, Wylie W. Vale, and Tracy L. Bale PMCID: PMC1413935 Plant Biology Genes directly regulated by LEAFY COTYLEDON2 provide insight into the control of embryo maturation and somatic embryogenesis Siobhan A. Braybrook, Sandra L. Stone, Soomin Park, Anhthu Q. Bui, Brandon H. Le, Robert L. Fischer, Robert B. Goldberg, and John J. Harada PMCID: PMC1413938 Defining the primary route for lutein synthesis in plants: The role of Arabidopsis carotenoid β-ring hydroxylase CYP97A3 Joonyul Kim and Dean DellaPenna PMCID: PMC1413914 Psychology Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood Ian C. G. Weaver, Michael J. Meaney, and Moshe Szyf PMCID: PMC1413873 The multisensory representation of number in infancy Kerry E. Jordan and Elizabeth M. Brannon PMCID: PMC1413880 Social Sciences Psychology An optimal brain can be composed of conflicting agents Adi Livnat and Nicholas Pippenger PMCID: PMC1413902 Social Sciences Evolutionary dynamics of social dilemmas in structured heterogeneous populations F. C. Santos, J. M. Pacheco, and Tom Lenaerts PMCID: PMC1413882 |
