| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2006 February 7; 103(6): 1657–1658. doi: 10.1073/pnas.iti0606103.PMCID: PMC1413678 Commentary Protein–protein interactions for cancer therapy Curtis C. Harris PMCID: PMC1413676 Perspective Lewy bodies Clifford W. Shults PMCID: PMC1413649 Profiles Profile of Alan M. Lambowitz Nick Zagorski PMCID: PMC1413635 Profile of George Oster Regina Nuzzo PMCID: PMC1413643 Physical Sciences Applied Mathematics A method for determining the dependence of calcium oscillations on inositol trisphosphate oscillations J. Sneyd, K. Tsaneva-Atanasova, V. Reznikov, Y. Bai, M. J. Sanderson, and D. I. Yule PMCID: PMC1413622 Multiple events on single molecules: Unbiased estimation in single-molecule biophysics Daniel A. Koster, Chris H. Wiggins, and Nynke H. Dekker PMCID: PMC1413656 Chemistry A fast response mechanism for insulin storage in crystals may involve kink generation by association of 2D clusters Dimitra K. Georgiou and Peter G. Vekilov PMCID: PMC1413625 Geology Historical contingency and the purported uniqueness of evolutionary innovations Geerat J. Vermeij PMCID: PMC1413639 Biological Sciences Agricultural Sciences Interaction of MEQ protein and C-terminal-binding protein is critical for induction of lymphomas by Marek’s disease virus Andrew C. Brown, Susan J. Baigent, Lorraine P. Smith, Jason P. Chattoo, Lawrence J. Petherbridge, Pippa Hawes, Martin J. Allday, and Venugopal Nair PMCID: PMC1413633 Applied Biological Sciences Selection of biocatalysts for chemical synthesis Stephan van Sint Fiet, Jan B. van Beilen, and Bernard Witholt PMCID: PMC1413619 Zinc supplementation of young men alters metallothionein, zinc transporter, and cytokine gene expression in leukocyte populations Tolunay Beker Aydemir, Raymond K. Blanchard, and Robert J. Cousins PMCID: PMC1413653 Biochemistry A fast response mechanism for insulin storage in crystals may involve kink generation by association of 2D clusters Dimitra K. Georgiou and Peter G. Vekilov PMCID: PMC1413625 Crystal structure, catalytic mechanism, and mitogenic properties of Trypanosoma cruzi proline racemase Alejandro Buschiazzo, Maira Goytia, Francis Schaeffer, Wim Degrave, William Shepard, Christophe Grégoire, Nathalie Chamond, Alain Cosson, Armand Berneman, Nicolas Coatnoan, Pedro M. Alzari, and Paola Minoprio PMCID: PMC1413642 Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D Hui Zhu, Jayakrishnan Nandakumar, Jideofor Aniukwu, Li Kai Wang, Michael S. Glickman, Christopher D. Lima, and Stewart Shuman PMCID: PMC1413644 Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change Ewen Gallagher, Min Gao, Yun-Cai Liu, and Michael Karin PMCID: PMC1413664 Manipulating phospholipids for crystallization of a membrane transport protein Lan Guan, Irina N. Smirnova, Gill Verner, Shushi Nagamori, and H. Ronald Kaback PMCID: PMC1413674 Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis Noriyuki Miyoshi, Hammou Oubrahim, P. Boon Chock, and Earl R. Stadtman PMCID: PMC1413652 Biophysics Insight into autoproteolytic activation from the structure of cephalosporin acylase: A protein with two proteolytic chemistries Jin Kwang Kim, In Seok Yang, Hye Jeong Shin, Ki Joon Cho, Eui Kyung Ryu, Sun Hwa Kim, Sung Soo Park, and Kyung Hyun Kim PMCID: PMC1413634 Determination of the geometric structure of the metal site in a blue copper protein by paramagnetic NMR D. Flemming Hansen and Jens J. Led PMCID: PMC1413626 Polyproline II conformation is one of many local conformational states and is not an overall conformation of unfolded peptides and proteins Joanna Makowska, Sylwia Rodziewicz-Motowidło, Katarzyna Bagińska, Jorge A. Vila, Adam Liwo, Lech Chmurzyński, and Harold A. Scheraga PMCID: PMC1413657 Multiple events on single molecules: Unbiased estimation in single-molecule biophysics Daniel A. Koster, Chris H. Wiggins, and Nynke H. Dekker PMCID: PMC1413656 Weighting of experimental evidence in macromolecular structure determination Michael Habeck, Wolfgang Rieping, and Michael Nilges PMCID: PMC1413624 Prestressed F-actin networks cross-linked by hinged filamins replicate mechanical properties of cells M. L. Gardel, F. Nakamura, J. H. Hartwig, J. C. Crocker, T. P. Stossel, and D. A. Weitz PMCID: PMC1413620 Cell Biology Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency G. López-Lluch, N. Hunt, B. Jones, M. Zhu, H. Jamieson, S. Hilmer, M. V. Cascajo, J. Allard, D. K. Ingram, P. Navas, and R. de Cabo PMCID: PMC1413655 Integrins regulate VE-cadherin and catenins: Dependence of this regulation on Src, but not on Ras Yingxiao Wang, Gang Jin, Hui Miao, Julie Y.-S. Li, Shunichi Usami, and Shu Chien PMCID: PMC1413667 Activation of phosphatidylinositol 3-kinase signaling by a mutant thyroid hormone β receptor Fumihiko Furuya, John A. Hanover, and Sheue-yann Cheng PMCID: PMC1413672 Chemosensing in Escherichia coli: Two regimes of two-state receptors Juan E. Keymer, Robert G. Endres, Monica Skoge, Yigal Meir, and Ned S. Wingreen PMCID: PMC1413630 Developmental Biology Immortalized keratinocyte lines derived from human embryonic stem cells Shiro Iuchi, Sally Dabelsteen, Karen Easley, James G. Rheinwald, and Howard Green PMCID: PMC1413677 Evolution Transposable elements have contributed to thousands of human proteins Roy Britten PMCID: PMC1413650 Historical contingency and the purported uniqueness of evolutionary innovations Geerat J. Vermeij PMCID: PMC1413639 Genetics Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels Jonathan C. Cohen, Alexander Pertsemlidis, Saleemah Fahmi, Sophie Esmail, Gloria L. Vega, Scott M. Grundy, and Helen H. Hobbs PMCID: PMC1413637 Suppression of gross chromosomal rearrangements by yKu70-yKu80 heterodimer through DNA damage checkpoints Soma Banerjee, Stephanie Smith, and Kyungjae Myung PMCID: PMC1413618 Immunology Development of CD4+ T cells expressing a nominally MHC class I-restricted T cell receptor by two different mechanisms Qing Ge, Phillip D. Holler, Vinay S. Mahajan, Tam Nuygen, Herman N. Eisen, and Jianzhu Chen PMCID: PMC1413658 Activation of anti-hepatitis C virus responses via Toll-like receptor 7 Jongdae Lee, Christina C. N. Wu, Ki Jeong Lee, Tsung-Hsien Chuang, Kyoko Katakura, Yu-Tsueng Liu, Michael Chan, Rommel Tawatao, Michelle Chung, Carol Shen, Howard B. Cottam, Michael M. C. Lai, Eyal Raz, and Dennis A. Carson PMCID: PMC1413670 Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury Thorsten Berger, Atsushi Togawa, Gordon S. Duncan, Andrew J. Elia, Annick You-Ten, Andrew Wakeham, Hannah E. H. Fong, Carol C. Cheung, and Tak W. Mak PMCID: PMC1413671 Nod1-dependent control of tumor growth Jean da Silva Correia, Yvonne Miranda, Nikki Austin-Brown, Jenny Hsu, John Mathison, Rong Xiang, Huamin Zhou, Qinxi Li, Jiahuai Han, and Richard J. Ulevitch PMCID: PMC1413646 First molecular and biochemical analysis of in vivo affinity maturation in an ectothermic vertebrate Helen Dooley, Robyn L. Stanfield, Rebecca A. Brady, and Martin F. Flajnik PMCID: PMC1413636 Medical Sciences In situ labeling of immune cells with iron oxide particles: An approach to detect organ rejection by cellular MRI Yijen L. Wu, Qing Ye, Lesley M. Foley, T. Kevin Hitchens, Kazuya Sato, John B. Williams, and Chien Ho PMCID: PMC1413627 In vivo disruption of TGF-β signaling by Smad7 leads to premalignant ductal lesions in the pancreas Chenzhong Kuang, Yan Xiao, Xubao Liu, Teresa M. Stringfield, Shaobo Zhang, Zhenzhen Wang, and Yan Chen PMCID: PMC1413640 The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase Vladimir Vartanian, Brian Lowell, Irina G. Minko, Thomas G. Wood, Jeffrey D. Ceci, Shakeeta George, Scott W. Ballinger, Christopher L. Corless, Amanda K. McCullough, and R. Stephen Lloyd PMCID: PMC1413631 C/EBPβ is a critical mediator of steroid hormone-regulated cell proliferation and differentiation in the uterine epithelium and stroma Srinivasa Raju Mantena, Athilakshmi Kannan, Yong-Pil Cheon, Quanxi Li, Peter F. Johnson, Indrani C. Bagchi, and Milan K. Bagchi PMCID: PMC1413629 Potent diarrheagenic mechanism mediated by the cooperative action of three enteropathogenic Escherichia coli-injected effector proteins Paul Dean, Marc Maresca, Stephanie Schüller, Alan D. Phillips, and Brendan Kenny PMCID: PMC1413648 Chimpanzee/human mAbs to vaccinia virus B5 protein neutralize vaccinia and smallpox viruses and protect mice against vaccinia virus Zhaochun Chen, Patricia Earl, Jeffrey Americo, Inger Damon, Scott K. Smith, Yi-Hua Zhou, Fujuan Yu, Andrew Sebrell, Suzanne Emerson, Gary Cohen, Roselyn J. Eisenberg, Juraj Svitel, Peter Schuck, William Satterfield, Bernard Moss, and Robert Purcell PMCID: PMC1413659 From the Cover:
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in
cancer: Implications for therapy Christian Tovar, James Rosinski, Zoran Filipovic, Brian Higgins, Kenneth Kolinsky, Holly Hilton, Xiaolan Zhao, Binh T. Vu, Weiguo Qing, Kathryn Packman, Ola Myklebost, David C. Heimbrook, and Lyubomir T. Vassilev PMCID: PMC1413632 Microbiology From the Cover:
Chlamydia trachomatis polymorphic membrane protein D is a species-common pan-neutralizing antigen Deborah D. Crane, John H. Carlson, Elizabeth R. Fischer, Patrik Bavoil, Ru-ching Hsia, Chun Tan, Cho-chou Kuo, and Harlan D. Caldwell PMCID: PMC1413641 RNAs induced by Epstein–Barr virus nuclear antigen 2 in lymphoblastoid cell lines Bo Zhao, Seiji Maruo, Andrew Cooper, Michael R. Chase, Eric Johannsen, Elliott Kieff, and Ellen Cahir-McFarland PMCID: PMC1413661 Transcriptome of Salmonella enterica serovar Typhi within macrophages revealed through the selective capture of transcribed sequences Sébastien P. Faucher, Steffen Porwollik, Charles M. Dozois, Michael McClelland, and France Daigle PMCID: PMC1413645 Neuroscience In vivo imaging of juxtaglomerular neuron turnover in the mouse olfactory bulb Adi Mizrahi, Jing Lu, Ryan Irving, Guoping Feng, and Lawrence C. Katz PMCID: PMC1413623 Imaging hair cell transduction at the speed of sound: Dynamic behavior of mammalian stereocilia Anders Fridberger, Igor Tomo, Mats Ulfendahl, and Jacques Boutet de Monvel PMCID: PMC1413628 The diacylglycerol-binding protein α1-chimaerin regulates dendritic morphology Philip Buttery, Asim A. Beg, Ben Chih, Arkady Broder, Carol A. Mason, and Peter Scheiffele PMCID: PMC1413663 The role of neuregulin–ErbB4 interactions on the proliferation and organization of cells in the subventricular zone H. T. Ghashghaei, Janet Weber, Larysa Pevny, Ralf Schmid, Markus H. Schwab, K. C. Kent Lloyd, David D. Eisenstat, Cary Lai, and E. S. Anton PMCID: PMC1413654 Phospholipase D1 corrects impaired βAPP trafficking and neurite outgrowth in familial Alzheimer’s disease-linked presenilin-1 mutant neurons Dongming Cai, Minghao Zhong, Runsheng Wang, William J. Netzer, Dennis Shields, Hui Zheng, Sangram S. Sisodia, David A. Foster, Fred S. Gorelick, Huaxi Xu, and Paul Greengard PMCID: PMC1413666 Presenilin-1 uses phospholipase D1 as a negative regulator of β-amyloid formation Dongming Cai, William J. Netzer, Minghao Zhong, Yixin Lin, Guangwei Du, Michael Frohman, David A. Foster, Sangram S. Sisodia, Huaxi Xu, Fred S. Gorelick, and Paul Greengard PMCID: PMC1413665 Illusory motion in Enigma: A psychophysical investigation T. Kumar and D. A. Glaser PMCID: PMC1413651 From the Cover:
Aβ and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer’s disease Jian-Ping Guo, Tetsuaki Arai, Judit Miklossy, and Patrick L. McGeer PMCID: PMC1413647 Differential involvement of the hippocampus, anterior cingulate cortex, and basolateral amygdala in memory for context and footshock Emily L. Malin and James L. McGaugh PMCID: PMC1413673 Regulation of blood flow in activated human brain by cytosolic NADH/NAD+ ratio Andrei G. Vlassenko, Melissa M. Rundle, Marcus E. Raichle, and Mark A. Mintun PMCID: PMC1413662 From the Cover:
Odorant responses of olfactory sensory neurons expressing the odorant receptor MOR23: A patch clamp analysis in gene-targeted mice Xavier Grosmaitre, Anne Vassalli, Peter Mombaerts, Gordon M. Shepherd, and Minghong Ma PMCID: PMC1413638 Physiology A method for determining the dependence of calcium oscillations on inositol trisphosphate oscillations J. Sneyd, K. Tsaneva-Atanasova, V. Reznikov, Y. Bai, M. J. Sanderson, and D. I. Yule PMCID: PMC1413622 WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway Paola de los Heros, Kristopher T. Kahle, Jesse Rinehart, Norma A. Bobadilla, Norma Vázquez, Pedro San Cristobal, David B. Mount, Richard P. Lifton, Steven C. Hebert, and Gerardo Gamba PMCID: PMC1413675 Subunit–subunit interactions are critical for proton sensitivity of ROMK: Evidence in support of an intermolecular gating mechanism Qiang Leng, Gordon G. MacGregor, Ke Dong, Gerhard Giebisch, and Steven C. Hebert PMCID: PMC1413660 Plant Biology Abscisic acid-dependent multisite phosphorylation regulates the activity of a transcription activator AREB1 Takashi Furihata, Kyonoshin Maruyama, Yasunari Fujita, Taishi Umezawa, Riichiro Yoshida, Kazuo Shinozaki, and Kazuko Yamaguchi-Shinozaki PMCID: PMC1413621 From the Cover:
F-box-like domain in the polerovirus protein P0 is required for silencing suppressor function Maghsoud Pazhouhandeh, Monika Dieterle, Katia Marrocco, Esther Lechner, Bassam Berry, Véronique Brault, Odile Hemmer, Thomas Kretsch, Kenneth E. Richards, Pascal Genschik, and Véronique Ziegler-Graff PMCID: PMC1413668 Correction Correction for Munoz et al., Human steprogenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice PMCID: PMC1413669 Corrects: James R. Munoz, et al. Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice. Proc Natl Acad Sci U S A. 2005 December 13; 102(50): 18171–18176. |
