| | This journal provides immediate access to some articles. Commentary Tracking the cryptic pumiliotoxins Stanton Q. Smith and Tappey H. Jones PMCID: PMC419517 Physical Sciences Applied Physical Sciences From the Cover:
Shape insensitive optimal adhesion of nanoscale fibrillar structures Huajian Gao and Haimin Yao PMCID: PMC419520 Microtesla MRI with a superconducting quantum interference device Robert McDermott, SeungKyun Lee, Bennie ten Haken, Andreas H. Trabesinger, Alexander Pines, and John Clarke PMCID: PMC419521 Chemistry Scanning electrochemical microscopy of menadione-glutathione conjugate export from yeast cells Janine Mauzeroll and Allen J. Bard PMCID: PMC419522 Identification of Ald6p as the target of a class of small-molecule suppressors of FK506 and their use in network dissection Rebecca A. Butcher and Stuart L. Schreiber PMCID: PMC419523 From the Cover:
Formicine ants: An arthropod source for the pumiliotoxin alkaloids of dendrobatid poison frogs Ralph A. Saporito, H. Martin Garraffo, Maureen A. Donnelly, Adam L. Edwards, John T. Longino, and John W. Daly PMCID: PMC419554 Engineering Programmable motion and patterning of molecules on solid surfaces Z. Suo and W. Hong PMCID: PMC419524 Geophysics Flint mining in prehistory recorded by in situ-produced cosmogenic 10Be G. Verri, R. Barkai, C. Bordeanu, A. Gopher, M. Hass, A. Kaufman, P. Kubik, E. Montanari, M. Paul, A. Ronen, S. Weiner, and E. Boaretto PMCID: PMC419525 Statistics INAUGURAL ARTICLE by a Recently Elected Academy Member: Biography of David O. Siegmund David Appell PMCID: PMC419518 INAUGURAL ARTICLE by a Recently Elected Academy Member: Mapping quantitative traits with random and with ascertained sibships Jie Peng and D. Siegmund PMCID: PMC419519 Biological Sciences Biochemistry A model for Ure2p prion filaments and other amyloids: The parallel superpleated β-structure Andrey V. Kajava, Ulrich Baxa, Reed B. Wickner, and Alasdair C. Steven PMCID: PMC419526 The mechanism of transmembrane S-nitrosothiol transport Yanhong Zhang and Neil Hogg PMCID: PMC419527 From the Cover:
The ribosome as an entropy trap Annette Sievers, Malte Beringer, Marina V. Rodnina, and Richard Wolfenden PMCID: PMC419528 Trigger factor binds to ribosome–signal-recognition particle (SRP) complexes and is excluded by binding of the SRP receptor Iwona Buskiewicz, Elke Deuerling, Shan-Qing Gu, Johannes Jöckel, Marina V. Rodnina, Bernd Bukau, and Wolfgang Wintermeyer PMCID: PMC419529 Computational design of receptors for an organophosphate surrogate of the nerve agent soman Malin Allert, Shahir S. Rizk, Loren L. Looger, and Homme W. Hellinga PMCID: PMC419530 Quinone biogenesis: Structure and mechanism of PqqC, the final catalyst in the production of pyrroloquinoline quinone Olafur Th. Magnusson, Hirohide Toyama, Megumi Saeki, Ana Rojas, John C. Reed, Robert C. Liddington, Judith P. Klinman, and Robert Schwarzenbacher PMCID: PMC419531 A new activity for an old enzyme: Escherichia coli bacterial alkaline phosphatase is a phosphite-dependent hydrogenase Kechao Yang and William W. Metcalf PMCID: PMC419532 Design of temperature-sensitive mutants solely from amino acid sequence Ghadiyaram Chakshusmathi, Kajari Mondal, G. Santosh Lakshmi, Guramrit Singh, Ankita Roy, Ravindra Babu Ch., S. Madhusudhanan, and Raghavan Varadarajan PMCID: PMC419533 The crystal structure of xanthine oxidoreductase during catalysis: Implications for reaction mechanism and enzyme inhibition Ken Okamoto, Koji Matsumoto, Russ Hille, Bryan T. Eger, Emil F. Pai, and Takeshi Nishino PMCID: PMC419534 Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome Yakir Moshe, Jérôme Boulaire, Michele Pagano, and Avram Hershko PMCID: PMC419535 Activity-based probes for protein tyrosine phosphatases Sanjai Kumar, Bo Zhou, Fubo Liang, Wei-Qing Wang, Zhonghui Huang, and Zhong-Yin Zhang PMCID: PMC419536 Biophysics Mechanical tweezer action by self-tightening knots in surfactant nanotubes Tatsiana Lobovkina, Paul Dommersnes, Jean-Francois Joanny, Patricia Bassereau, Mattias Karlsson, and Owe Orwar PMCID: PMC419537 Dramatic acceleration of protein folding by stabilization of a nonnative backbone conformation Ariel A. Di Nardo, Dmitry M. Korzhnev, Peter J. Stogios, Arash Zarrine-Afsar, Lewis E. Kay, and Alan R. Davidson PMCID: PMC419538 Geometry and symmetry presculpt the free-energy landscape of proteins Trinh Xuan Hoang, Antonio Trovato, Flavio Seno, Jayanth R. Banavar, and Amos Maritan PMCID: PMC419539 Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles Irene A. Chen and Jack W. Szostak PMCID: PMC419540 Resonant optical rectification in bacteriorhodopsin Géza I. Groma, Anne Colonna, Jean-Christophe Lambry, Jacob W. Petrich, György Váró, Manuel Joffre, Marten H. Vos, and Jean-Louis Martin PMCID: PMC419541 Φ-Value analysis and the nature of protein-folding transition states Alan R. Fersht and Satoshi Sato PMCID: PMC419542 Cell Biology Discovery and characterization of an epithelial-specific galectin in the endometrium that forms crystals in the trophectoderm C. Allison Gray, David L. Adelson, Fuller W. Bazer, Robert C. Burghardt, Els N. T. Meeusen, and Thomas E. Spencer PMCID: PMC419543 Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria Damien Arnoult, Laura M. Bartle, Anna Skaletskaya, Delphine Poncet, Naoufal Zamzami, Peter U. Park, Juanita Sharpe, Richard J. Youle, and Victor S. Goldmacher PMCID: PMC419544 Inhibitor of κB kinase is required to activate a subset of interferon γ-stimulated genes Nywana Sizemore, Anju Agarwal, Kingshuk Das, Natalia Lerner, Michael Sulak, Sandhya Rani, Richard Ransohoff, David Shultz, and George R. Stark PMCID: PMC419545 Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging Ahmet Koc, Audrey P. Gasch, Julian C. Rutherford, Hwa-Young Kim, and Vadim N. Gladyshev PMCID: PMC419546 E-selectin is required for the antiangiogenic activity of endostatin Ying Yu, Karen S. Moulton, Mohamed K. Khan, Sabrina Vineberg, Eileen Boye, Vannessa M. Davis, Peter E. O'Donnell, Joyce Bischoff, and David S. Milstone PMCID: PMC419547 Developmental Biology Establishment of a normal medakafish spermatogonial cell line capable of sperm production in vitro Yunhan Hong, Tongming Liu, Haobin Zhao, Hongyan Xu, Weijia Wang, Rong Liu, Tiansheng Chen, Jiaorong Deng, and Jianfang Gui PMCID: PMC419548 Anteriorization of neural fate by inhibitor of β-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling Kiyotoshi Satoh, Mana Kasai, Takefumi Ishidao, Kenichi Tago, Susumu Ohwada, Yoshimi Hasegawa, Takao Senda, Shinji Takada, Shigeyuki Nada, Tsutomu Nakamura, and Tetsu Akiyama PMCID: PMC419549 A balance between the diap1 death inhibitor and reaper and hid death inducers controls steroid-triggered cell death in Drosophila Viravuth P. Yin and Carl S. Thummel PMCID: PMC419550 Endometrial calbindins are critical for embryo implantation: Evidence from in vivo use of morpholino antisense oligonucleotides Kien C. Luu, Gui Ying Nie, and Lois A. Salamonsen PMCID: PMC419551 Telomere length is reset during early mammalian embryogenesis Sonja Schaetzlein, Andrea Lucas-Hahn, Erika Lemme, Wilfried A. Kues, Martina Dorsch, Michael P. Manns, Heiner Niemann, and K. Lenhard Rudolph PMCID: PMC419552 Auxin regulation of cytokinin biosynthesis in Arabidopsis thaliana: A factor of potential importance for auxin–cytokinin-regulated development Anders Nordström, Petr Tarkowski, Danuse Tarkowska, Rikke Norbaek, Crister Åstot, Karel Dolezal, and Göran Sandberg PMCID: PMC419553 Ecology From the Cover:
Formicine ants: An arthropod source for the pumiliotoxin alkaloids of dendrobatid poison frogs Ralph A. Saporito, H. Martin Garraffo, Maureen A. Donnelly, Adam L. Edwards, John T. Longino, and John W. Daly PMCID: PMC419554 Previous-year reproduction reduces photosynthetic capacity and slows lifetime growth in females of a neotropical tree Nathaniel T. Wheelwright and Barry A. Logan PMCID: PMC419555 Evolution Cretaceous flowers of Nymphaeaceae and implications for complex insect entrapment pollination mechanisms in early Angiosperms M. A. Gandolfo, K. C. Nixon, and W. L. Crepet PMCID: PMC419556 Genetic variation in cancer predisposition: Mutational decay of a robust genetic control network Steven A. Frank PMCID: PMC419557 From the Cover:
The twilight of Heliozoa and rise of Rhizaria, an emerging supergroup of amoeboid eukaryotes Sergey I. Nikolaev, Cédric Berney, José F. Fahrni, Ignacio Bolivar, Stephane Polet, Alexander P. Mylnikov, Vladimir V. Aleshin, Nikolai B. Petrov, and Jan Pawlowski PMCID: PMC419558 The evolution of a pleiotropic fitness tradeoff in Pseudomonas fluorescens R. Craig MacLean, Graham Bell, and Paul B. Rainey PMCID: PMC419559 Genetics Identification of Ald6p as the target of a class of small-molecule suppressors of FK506 and their use in network dissection Rebecca A. Butcher and Stuart L. Schreiber PMCID: PMC419523 Cti1/C1D interacts with condensin SMC hinge and supports the DNA repair function of condensin Ee Sin Chen, Takashi Sutani, and Mitsuhiro Yanagida PMCID: PMC419560 Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans Cheng Huang, Chengjie Xiong, and Kerry Kornfeld PMCID: PMC419561 SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1–SIX1–DNA complexes Rainer G. Ruf, Pin-Xian Xu, Derek Silvius, Edgar A. Otto, Frank Beekmann, Ulla T. Muerb, Shrawan Kumar, Thomas J. Neuhaus, Markus J. Kemper, Richard M. Raymond, Jr., Patrick D. Brophy, Jennifer Berkman, Michael Gattas, Valentine Hyland, Eva-Maria Ruf, Charles Schwartz, Eugene H. Chang, Richard J. H. Smith, Constantine A. Stratakis, Dominique Weil, Christine Petit, and Friedhelm Hildebrandt PMCID: PMC419562 The minimal promoter plays a major role in silencing of the galago γ-globin gene in adult erythropoiesis Qiliang Li, Xiangdong Fang, Hemei Han, and George Stamatoyannopoulos PMCID: PMC419563 Immunology Natural killer cells distinguish innocuous and destructive forms of pancreatic islet autoimmunity Laurent Poirot, Christophe Benoist, and Diane Mathis PMCID: PMC419564 Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-κB activation pathways Brian Zarnegar, Jeannie Q. He, Gagik Oganesyan, Alexander Hoffmann, David Baltimore, and Genhong Cheng PMCID: PMC419565 The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1 Kefang Xie, Mark P. Sowden, Geoffrey S. C. Dance, Andrew T. Torelli, Harold C. Smith, and Joseph E. Wedekind PMCID: PMC419566 Inhibition of acute graft-versus-host disease with retention of graft-versus-tumor effects by the proteasome inhibitor bortezomib Kai Sun, Lisbeth A. Welniak, Angela Panoskaltsis-Mortari, Matthew J. O'Shaughnessy, Haiyan Liu, Isabel Barao, William Riordan, Raquel Sitcheran, Christian Wysocki, Jonathan S. Serody, Bruce R. Blazar, Thomas J. Sayers, and William J. Murphy PMCID: PMC419567 NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling Makoto Ohtsuka, Hisashi Arase, Arata Takeuchi, Sho Yamasaki, Ritsuko Shiina, Tadahiro Suenaga, Daiju Sakurai, Tadashi Yokosuka, Noriko Arase, Makio Iwashima, Toshio Kitamura, Hideshige Moriya, and Takashi Saito PMCID: PMC419568 Medical Sciences Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates Tetsufumi Koike, Naoko Kimura, Keiko Miyazaki, Tomonori Yabuta, Kensuke Kumamoto, Seiichi Takenoshita, Jian Chen, Masanobu Kobayashi, Masuo Hosokawa, Akiyoshi Taniguchi, Tetsuhito Kojima, Nobuhiro Ishida, Masao Kawakita, Harumi Yamamoto, Hiromu Takematsu, Akemi Suzuki, Yasunori Kozutsumi, and Reiji Kanangi PMCID: PMC419569 Leptin modulates β cell expression of IL-1 receptor antagonist and release of IL-1β in human islets Kathrin Maedler, Pavel Sergeev, Jan A. Ehses, Zoltan Mathe, Domenico Bosco, Thierry Berney, Jean-Michel Dayer, Manfred Reinecke, Philippe A. Halban, and Marc Y. Donath PMCID: PMC419570 Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancer Hiroyuki Yoshida, Wenjun Cheng, Jamie Hung, Denise Montell, Erika Geisbrecht, Daniel Rosen, Jinsong Liu, and Honami Naora PMCID: PMC419571 Reversal of cystic fibrosis phenotype in a cultured Δ508 cystic fibrosis transmembrane conductance regulator cell line by oligonucleotide insertion Paul C. Zamecnik, Malay K. Raychowdhury, David R. Tabatadze, and Horacio F. Cantiello PMCID: PMC419572 Microbiology H5N1 influenza: A protean pandemic threat Y. Guan, L. L. M. Poon, C. Y. Cheung, T. M. Ellis, W. Lim, A. S. Lipatov, K. H. Chan, K. M. Sturm-Ramirez, C. L. Cheung, Y. H. C. Leung, K. Y. Yuen, R. G. Webster, and J. S. M. Peiris PMCID: PMC419573 Neuroscience Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2 Ruiben Feng, Huimin Wang, Jianlin Wang, David Shrom, Xuemei Zeng, and Joe Z. Tsien PMCID: PMC419574 Molecular changes in neurons in multiple sclerosis: Altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger Matthew J. Craner, Jia Newcombe, Joel A. Black, Caroline Hartle, M. Louise Cuzner, and Stephen G. Waxman PMCID: PMC419575 From the Cover:
Dynamic mapping of human cortical development during childhood through early adulthood Nitin Gogtay, Jay N. Giedd, Leslie Lusk, Kiralee M. Hayashi, Deanna Greenstein, A. Catherine Vaituzis, Tom F. Nugent, III, David H. Herman, Liv S. Clasen, Arthur W. Toga, Judith L. Rapoport, and Paul M. Thompson PMCID: PMC419576 T cell deficiency leads to cognitive dysfunction: Implications for therapeutic vaccination for schizophrenia and other psychiatric conditions Jonathan Kipnis, Hagit Cohen, Michal Cardon, Yaniv Ziv, and Michal Schwartz PMCID: PMC419577 Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors John F. Cryan, Olivia F. O'Leary, Sung-Ha Jin, Julie C. Friedland, Ming Ouyang, Bradford R. Hirsch, Michelle E. Page, Ashutosh Dalvi, Steven A. Thomas, and Irwin Lucki PMCID: PMC419578 Hippocampal long-term depression and long-term potentiation encode different aspects of novelty acquisition Anne Kemp and Denise Manahan-Vaughan PMCID: PMC419579 Pharmacology A steroid modulatory domain on NR2B controls N-methyl-d-aspartate receptor proton sensitivity Ming-Kuei Jang, Dale F. Mierke, Shelley J. Russek, and David H. Farb PMCID: PMC419580 Physiology Placental-specific insulin-like growth factor 2 (Igf2) regulates the diffusional exchange characteristics of the mouse placenta C. P. Sibley, P. M. Coan, A. C. Ferguson-Smith, W. Dean, J. Hughes, P. Smith, W. Reik, G. J. Burton, A. L. Fowden, and M. Constância PMCID: PMC419581 Dehydroepiandrosterone and allopregnanolone protect sympathoadrenal medulla cells against apoptosis via antiapoptotic Bcl-2 proteins Ioannis Charalampopoulos, Christos Tsatsanis, Erene Dermitzaki, Vasilia-Ismini Alexaki, Elias Castanas, Andrew N. Margioris, and Achille Gravanis PMCID: PMC419582 Proximal renal tubular acidosis in TASK2 K+ channel-deficient mice reveals a mechanism for stabilizing bicarbonate transport Richard Warth, Hervé Barrière, Pierre Meneton, May Bloch, Jörg Thomas, Michel Tauc, Dirk Heitzmann, Elisa Romeo, François Verrey, Raymond Mengual, Nicolas Guy, Saïd Bendahhou, Florian Lesage, Philippe Poujeol, and Jacques Barhanin PMCID: PMC419583 Rescuing cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by transcomplementation Estelle Cormet-Boyaka, Michael Jablonsky, Anjaparavanda P. Naren, Patricia L. Jackson, Donald D. Muccio, and Kevin L. Kirk PMCID: PMC419584 Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference Katherine E. Wortley, Keith D. Anderson, Karen Garcia, Jane D. Murray, Lubomira Malinova, Rong Liu, Marshena Moncrieffe, Karen Thabet, Hilary J. Cox, George D. Yancopoulos, Stanley J. Wiegand, and Mark W. Sleeman PMCID: PMC419585 Plant Biology A gene cluster for secondary metabolism in oat: Implications for the evolution of metabolic diversity in plants X. Qi, S. Bakht, M. Leggett, C. Maxwell, R. Melton, and A. Osbourn PMCID: PMC419586 Suppression of pathogen-inducible NO synthase (iNOS) activity in tomato increases susceptibility to Pseudomonas syringae Meena R. Chandok, Sophia K. Ekengren, Gregory B. Martin, and Daniel F. Klessig PMCID: PMC419587 Camalexin is synthesized from indole-3-acetaldoxime, a key branching point between primary and secondary metabolism in Arabidopsis Erich Glawischnig, Bjarne Gram Hansen, Carl Erik Olsen, and Barbara Ann Halkier PMCID: PMC419588 Population Biology Coral decline threatens fish biodiversity in marine reserves Geoffrey P. Jones, Mark I. McCormick, Maya Srinivasan, and Janelle V. Eagle PMCID: PMC419589 Correction Proc Natl Acad Sci U S A. 2004 May 25; 101(21): 8254. doi: 10.1073/pnas.0402658101.PMCID: PMC419590 Corrects: Mark C. Carroll, et al. Mechanisms for activating Cu- and Zn-containing superoxide dismutase in the absence of the CCS Cu chaperone. Proc Natl Acad Sci U S A. 2004 April 20; 101(16): 5964–5969. |
