| | This journal provides immediate access to some articles. From the Academy The role of science in solving the world's emerging water problems William A. Jury and Henry Vaux, Jr PMCID: PMC1276073 In This Issue Proc Natl Acad Sci U S A. 2005 November 1; 102(44): 15713–15714. doi: 10.1073/iti4405102.PMCID: PMC1276114 Commentaries The search for glycan function: Fucosylation of the TGF-β1 receptor is required for receptor activation Harry Schachter PMCID: PMC1276088 The sodium pump and hypertension: A physiological role for the cardiac glycoside binding site of the Na,K-ATPase Jack H. Kaplan PMCID: PMC1276099 Profiles Profile of Stephen H. Schneider Regina Nuzzo PMCID: PMC1276082 Profile of Deborah P. Delmer Nick Zagorski PMCID: PMC1276077 Physical Sciences Applied Mathematics Species lifetime distribution for simple models of ecologies Simone Pigolotti, Alessandro Flammini, Matteo Marsili, and Amos Maritan PMCID: PMC1276042 Applied Physical Sciences In vitro and in vivo two-photon luminescence imaging of single gold nanorods Haifeng Wang, Terry B. Huff, Daniel A. Zweifel, Wei He, Philip S. Low, Alexander Wei, and Ji-Xin Cheng PMCID: PMC1276057 Marker-specific sorting of rare cells using dielectrophoresis Xiaoyuan Hu, Paul H. Bessette, Jiangrong Qian, Carl D. Meinhart, Patrick S. Daugherty, and Hyongsok T. Soh PMCID: PMC1276091 Chemistry Breath sulfides and pulmonary function in cystic fibrosis M. A. Kamboures, D. R. Blake, D. M. Cooper, R. L. Newcomb, M. Barker, J. K. Larson, S. Meinardi, E. Nussbaum, and F. S. Rowland PMCID: PMC1276081 Environmental Sciences INAUGURAL ARTICLE by a Recently Elected Academy Member: Probabilistic assessment of “dangerous” climate change and emissions pathways Stephen H. Schneider and Michael D. Mastrandrea PMCID: PMC1276072 Scientific issues in the design of metrics for inclusion of oxides of nitrogen in global climate agreements K. P. Shine, T. K. Berntsen, J. S. Fuglestvedt, and R. Sausen PMCID: PMC1276078 Geophysics Fine-scale processes regulate the response of extreme events to global climate change Noah S. Diffenbaugh, Jeremy S. Pal, Robert J. Trapp, and Filippo Giorgi PMCID: PMC1276070 Biological Sciences Agricultural Sciences INAUGURAL ARTICLE by a Recently Elected Academy Member: Agriculture in the developing world: Connecting innovations in plant research to downstream applications Deborah P. Delmer PMCID: PMC1200091 Applied Biological Sciences Synergy between interstitial flow and VEGF directs capillary morphogenesis in vitro through a gradient amplification mechanism Cara-Lynn E. Helm, Mark E. Fleury, Andreas H. Zisch, Federica Boschetti, and Melody A. Swartz PMCID: PMC1276047 Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry Mathias Ehrich, Matthew R. Nelson, Patrick Stanssens, Marc Zabeau, Triantafillos Liloglou, George Xinarianos, Charles R. Cantor, John K. Field, and Dirk van den Boom PMCID: PMC1276092 Biochemistry From the Cover:
Dysregulation of TGF-β1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice Xiangchun Wang, Shinya Inoue, Jianguo Gu, Eiji Miyoshi, Katsuhisa Noda, Wenzhe Li, Yoko Mizuno-Horikawa, Miyako Nakano, Michio Asahi, Motoko Takahashi, Naofumi Uozumi, Shinji Ihara, Seung Ho Lee, Yoshitaka Ikeda, Yukihiro Yamaguchi, Yoshiya Aze, Yoshiaki Tomiyama, Junichi Fujii, Keiichiro Suzuki, Akihiro Kondo, Steven D. Shapiro, Carlos Lopez-Otin, Tomoyuki Kuwaki, Masaru Okabe, Koichi Honke, and Naoyuki Taniguchi PMCID: PMC1257418 Structure of the metal-independent restriction enzyme BfiI reveals fusion of a specific DNA-binding domain with a nonspecific nuclease Saulius Grazulis, Elena Manakova, Manfred Roessle, Matthias Bochtler, Giedre Tamulaitiene, Robert Huber, and Virginijus Siksnys PMCID: PMC1266039 Probing the active site tightness of DNA polymerase in subangstrom increments Tae Woo Kim, James C. Delaney, John M. Essigmann, and Eric T. Kool PMCID: PMC1276059 Multiple modes of interaction of the deglycosylation enzyme, mouse peptide N-glycanase, with the proteasome Guangtao Li, Xiaoke Zhou, Gang Zhao, Hermann Schindelin, and William J. Lennarz PMCID: PMC1276080 Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase Jun Yin, Paul D. Straight, Shaun M. McLoughlin, Zhe Zhou, Alison J. Lin, David E. Golan, Neil L. Kelleher, Roberto Kolter, and Christopher T. Walsh PMCID: PMC1276090 A structural model for maturation of the hepatitis B virus core Alan M. Roseman, John A. Berriman, Samantha A. Wynne, P. Jonathan G. Butler, and R. Anthony Crowther PMCID: PMC1276056 A fully dissociated compound of plant origin for inflammatory gene repression Karolien De Bosscher, Wim Vanden Berghe, Ilse M. E. Beck, Wim Van Molle, Nathalie Hennuyer, Janet Hapgood, Claude Libert, Bart Staels, Ann Louw, and Guy Haegeman PMCID: PMC1276063 Recruitment of governing elements for electron transfer in the nitric oxide synthase family M. Jáchymová, P. Martásek, S. Panda, L. J. Roman, M. Panda, T. M. Shea, Y. Ishimura, J.-J. P. Kim, and B. S. S. Masters PMCID: PMC1276075 Crystal structure of the Bacillus subtilis anti-alpha, global transcriptional regulator, Spx, in complex with the α C-terminal domain of RNA polymerase Kate J. Newberry, Shunji Nakano, Peter Zuber, and Richard G. Brennan PMCID: PMC1266077 From the Cover:
The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation Iva Dostanic-Larson, James W. Van Huysse, John N. Lorenz, and Jerry B Lingrel PMCID: PMC1276084 Biophysics A geometric construction determines all permissible strand arrangements of sandwich proteins A. S. Fokas, T. S. Papatheodorou, A. E. Kister, and I. M. Gelfand PMCID: PMC1276083 Simulating movement of tRNA into the ribosome during decoding Kevin Y. Sanbonmatsu, Simpson Joseph, and Chang-Shung Tung PMCID: PMC1266076 Spectral and redox characterization of the heme ci of the cytochrome b6f complex Jean Alric, Yves Pierre, Daniel Picot, Jérôme Lavergne, and Fabrice Rappaport PMCID: PMC1276102 Light scattered by model phantom bacteria reveals molecular interactions at their surface A. Ghetta, D. Prosperi, F. Mantegazza, L. Panza, S. Riva, and T. Bellini PMCID: PMC1276067 Molecular-level secondary structure, polymorphism, and dynamics of full-length α-synuclein fibrils studied by solid-state NMR Henrike Heise, Wolfgang Hoyer, Stefan Becker, Ovidiu C. Andronesi, Dietmar Riedel, and Marc Baldus PMCID: PMC1276071 Pore conformations and gating mechanism of a Cys-loop receptor Yoav Paas, Gilad Gibor, Regis Grailhe, Nathalie Savatier-Duclert, Virginie Dufresne, Morten Sunesen, Lia Prado de Carvalho, Jean-Pierre Changeux, and Bernard Attali PMCID: PMC1276086 From the Cover:
Measurement of the contributions of 1D and 3D pathways to the translocation of a protein along DNA Darren M. Gowers, Geoffrey G. Wilson, and Stephen E. Halford PMCID: PMC1262116 Cell Biology 3D structure of eukaryotic flagella in a quiescent state revealed by cryo-electron tomography Daniela Nicastro, J. Richard McIntosh, and Wolfgang Baumeister PMCID: PMC1276108 From the Cover:
Cooperative effects of Rho and mechanical stretch on stress fiber organization Roland Kaunas, Phu Nguyen, Shunichi Usami, and Shu Chien PMCID: PMC1276069 Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1 Edward Htun van der Horst, Yan Y. Degenhardt, Astrid Strelow, Anthony Slavin, Lawrence Chinn, Jessica Orf, Minqing Rong, Shyun Li, Lei-Hoon See, Ken Q. C. Nguyen, Timothy Hoey, Holger Wesche, and Scott Powers PMCID: PMC1276100 Developmental Biology Spatial regulation of microRNA gene expression in the Drosophila embryo Frédéric Biemar, Robert Zinzen, Matthew Ronshaugen, Victor Sementchenko, J. Robert Manak, and Michael S. Levine PMCID: PMC1276093 Diapause in the mosquito Culex pipiens evokes a metabolic switch from blood feeding to sugar gluttony Rebecca M. Robich and David L. Denlinger PMCID: PMC1276097 Involvement of winged eye encoding a chromatin-associated bromo-adjacent homology domain protein in disc specification Tomonori Katsuyama, Tomo Sugawara, Masanobu Tatsumi, Yoshiteru Oshima, Walter J. Gehring, Toshiro Aigaki, and Shoichiro Kurata PMCID: PMC1276095 Evolution Adaptation and incipient sympatric speciation of Bacillus simplex under microclimatic contrast at “Evolution Canyons” I and II, Israel Johannes Sikorski and Eviatar Nevo PMCID: PMC1276094 Centromere-proximal differentiation and speciation in Anopheles gambiae Aram D. Stump, Meagan C. Fitzpatrick, Neil F. Lobo, Sékou Traoré, N′Fale Sagnon, Carlo Costantini, Frank H. Collins, and Nora J. Besansky PMCID: PMC1276105 Evolutionary population genetics of promoters: Predicting binding sites and functional phylogenies Ville Mustonen and Michael Lässig PMCID: PMC1276062 Support from the relationship of genetic and geographic distance in human populations for a serial founder effect originating in Africa Sohini Ramachandran, Omkar Deshpande, Charles C. Roseman, Noah A. Rosenberg, Marcus W. Feldman, and L. Luca Cavalli-Sforza PMCID: PMC1276087 Genetics Distinctions in the specificity of E2F function revealed by gene expression signatures Esther P. Black, Timothy Hallstrom, Holly K. Dressman, Mike West, and Joseph R. Nevins PMCID: PMC1276052 The error-free component of the RAD6/RAD18 DNA damage tolerance pathway of budding yeast employs sister-strand recombination Hengshan Zhang and Christopher W. Lawrence PMCID: PMC1276054 Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita Mary Armanios, Jiunn-Liang Chen, Yen-Pei Christy Chang, Robert A. Brodsky, Anita Hawkins, Constance A. Griffin, James R. Eshleman, Alan R. Cohen, Aravinda Chakravarti, Ada Hamosh, and Carol W. Greider PMCID: PMC1276104 Evidence for maternally transmitted small interfering RNA in the repression of transposition in Drosophila virilis Justin P. Blumenstiel and Daniel L. Hartl PMCID: PMC1276106 From the Cover:
Combining two genomes in one cell: Stable cloning of the Synechocystis PCC6803 genome in the Bacillus subtilis 168 genome Mitsuhiro Itaya, Kenji Tsuge, Maki Koizumi, and Kyoko Fujita PMCID: PMC1276048 Identification of 14-3-3σ mutation causing cutaneous abnormality in repeated-epilation mutant mouse Qiutang Li, Qingxian Lu, Gabriela Estepa, and Inder M. Verma PMCID: PMC1276109 Essential role of Shp2-binding sites on FRS2α for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells S. Yamamoto, I. Yoshino, T. Shimazaki, M. Murohashi, R. F. Hevner, I. Lax, H. Okano, M. Shibuya, J. Schlessinger, and N. Gotoh PMCID: PMC1276098 Immunology Negative regulation of Toll-like-receptor signaling by IRF-4 Hideo Negishi, Yusuke Ohba, Hideyuki Yanai, Akinori Takaoka, Kiri Honma, Katsuyuki Yui, Toshifumi Matsuyama, Tadatsugu Taniguchi, and Kenya Honda PMCID: PMC1257749 The role of TNF-α in the pathogenesis of type 1 diabetes in the nonobese diabetic mouse: Analysis of dendritic cell maturation Li-Fen Lee, Baohui Xu, Sara A. Michie, Georg F. Beilhack, Tibor Warganich, Shannon Turley, and Hugh O. McDevitt PMCID: PMC1276103 Interferon regulatory factor 4 negatively regulates the production of proinflammatory cytokines by macrophages in response to LPS Kiri Honma, Heiichiro Udono, Tomoko Kohno, Kazuo Yamamoto, Asako Ogawa, Toshitada Takemori, Atsushi Kumatori, Shoichi Suzuki, Toshifumi Matsuyama, and Katsuyuki Yui PMCID: PMC1276050 Regulation of relB in dendritic cells by means of modulated association of vitamin D receptor and histone deacetylase 3 with the promoter Xiangyang Dong, Ward Lutz, Tania M. Schroeder, Lori A. Bachman, Jennifer J. Westendorf, Rajiv Kumar, and Matthew D. Griffin PMCID: PMC1257750 Medical Sciences The response of autologous T cells to a human melanoma is dominated by mutated neoantigens Volker Lennerz, Martina Fatho, Chiara Gentilini, Roy A. Frye, Alexander Lifke, Dorothea Ferel, Catherine Wölfel, Christoph Huber, and Thomas Wölfel PMCID: PMC1266037 Pivotal role of Harakiri in the induction and prevention of gentamicin-induced hearing loss Gilda M. Kalinec, Martin E. Fernandez-Zapico, Raul Urrutia, Nora Esteban-Cruciani, Shanping Chen, and Federico Kalinec PMCID: PMC1276101 Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans Martin Kohlmeier, Kerry-Ann da Costa, Leslie M. Fischer, and Steven H. Zeisel PMCID: PMC1276051 A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes Annick Le Dur, Vincent Béringue, Olivier Andréoletti, Fabienne Reine, Thanh Lan Laï, Thierry Baron, Bjørn Bratberg, Jean-Luc Vilotte, Pierre Sarradin, Sylvie L. Benestad, and Hubert Laude PMCID: PMC1276041 Microbiology Central role of a bacterial two-component gene regulatory system of previously unknown function in pathogen persistence in human saliva Samuel A. Shelburne, III, Paul Sumby, Izabela Sitkiewicz, Chanel Granville, Frank R. DeLeo, and James M. Musser PMCID: PMC1276065 Comparative phylogenomics of the food-borne pathogen Campylobacter jejuni reveals genetic markers predictive of infection source Olivia L. Champion, Michael W. Gaunt, Ozan Gundogdu, Abdi Elmi, Adam A. Witney, Jason Hinds, Nick Dorrell, and Brendan W. Wren PMCID: PMC1276044 A hypervariable N-terminal region of Yersinia LcrV determines Toll-like receptor 2-mediated IL-10 induction and mouse virulence Andreas Sing, Dagmar Reithmeier-Rost, Kaisa Granfors, Jim Hill, Andreas Roggenkamp, and Jürgen Heesemann PMCID: PMC1276055 Herpesviral latency-associated transcript gene promotes assembly of heterochromatin on viral lytic-gene promoters in latent infection Qing-Yin Wang, Changhong Zhou, Karen E. Johnson, Robert C. Colgrove, Donald M. Coen, and David M. Knipe PMCID: PMC1266038 Neuroscience Orbitofrontal cortex activity related to emotional processing changes across the menstrual cycle Xenia Protopopescu, Hong Pan, Margaret Altemus, Oliver Tuescher, Margaret Polanecsky, Bruce McEwen, David Silbersweig, and Emily Stern PMCID: PMC1276043 Prostaglandin E receptor EP1 controls impulsive behavior under stress Yoko Matsuoka, Tomoyuki Furuyashiki, Kiyofumi Yamada, Taku Nagai, Haruhiko Bito, Yasuhiro Tanaka, Shiho Kitaoka, Fumitaka Ushikubi, Toshitaka Nabeshima, and Shuh Narumiya PMCID: PMC1276058 Cofilin expression induces cofilin-actin rod formation and disrupts synaptic structure and function in Aplysia synapses Dong-Hyuk Jang, Jin-Hee Han, Seung-Hee Lee, Yong-Seok Lee, Hyungju Park, Sue-Hyun Lee, Hyoung Kim, and Bong-Kiun Kaang PMCID: PMC1276089 Pharmacology Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580 James G. Conway, Brad McDonald, Janet Parham, Barry Keith, David W. Rusnak, Eva Shaw, Marilyn Jansen, Peiyuan Lin, Alan Payne, Renae M. Crosby, Jennifer H. Johnson, Lloyd Frick, Min-Hwa Jasmine Lin, Scott Depee, Sarva Tadepalli, Bart Votta, Ian James, Karen Fuller, Timothy J. Chambers, Frederick C. Kull, Stanley D. Chamberlain, and Jeff T. Hutchins PMCID: PMC1276040 Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism Marián Castro, Viacheslav O. Nikolaev, Dieter Palm, Martin J. Lohse, and Jean-Pierre Vilardaga PMCID: PMC1276049 Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim Yan Zhao, Jing Tan, Li Zhuang, Xia Jiang, Edison T. Liu, and Qiang Yu PMCID: PMC1276064 Physiology Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice Yuki Takayanagi, Masahide Yoshida, Isadora F. Bielsky, Heather E. Ross, Masaki Kawamata, Tatsushi Onaka, Teruyuki Yanagisawa, Tadashi Kimura, Martin M. Matzuk, Larry J. Young, and Katsuhiko Nishimori PMCID: PMC1276060 pH sensing in the two-pore domain K+ channel, TASK2 Michael J. Morton, Abdulrahman Abohamed, Asipu Sivaprasadarao, and Malcolm Hunter PMCID: PMC1276079 Plant Biology Vacuolar Na+/H+ antiporter cation selectivity is regulated by calmodulin from within the vacuole in a Ca2+- and pH-dependent manner Toshio Yamaguchi, Gilad S. Aharon, Jordan B. Sottosanto, and Eduardo Blumwald PMCID: PMC1276053 AtCCMH, an essential component of the c-type cytochrome maturation pathway in Arabidopsis mitochondria, interacts with apocytochrome c Etienne H. Meyer, Philippe Giegé, Eric Gelhaye, Naganand Rayapuram, Umesh Ahuja, Linda Thöny-Meyer, Jean-Michel Grienenberger, and Géraldine Bonnard PMCID: PMC1276046 Corrections Proc Natl Acad Sci U S A. 2005 November 1; 102(44): 16119. Published online 2005 October 19. doi: 10.1073/pnas.0508220102.PMCID: PMC1276107 Corrects: Edward O. Wilson, et al. Eusociality: Origin and consequences. Proc Natl Acad Sci U S A. 2005 September 20; 102(38): 13367–13371. Proc Natl Acad Sci U S A. 2005 November 1; 102(44): 16119. Published online 2005 October 19. doi: 10.1073/pnas.0508348102.PMCID: PMC1276111 Corrects: Filiz M. Aslan, et al. Engineered single-chain dimeric streptavidins with an unexpected strong preference for biotin-4-fluorescein. Proc Natl Acad Sci U S A. 2005 June 14; 102(24): 8507–8512. Proc Natl Acad Sci U S A. 2005 November 1; 102(44): 16119. Published online 2005 October 21. doi: 10.1073/pnas.0508351102.PMCID: PMC1276112 Corrects: Cory M. Johannessen, et al. The NF1 tumor suppressor critically regulates TSC2 and mTOR. Proc Natl Acad Sci U S A. 2005 June 14; 102(24): 8573–8578. Proc Natl Acad Sci U S A. 2005 November 1; 102(44): 16120. Published online 2005 October 18. doi: 10.1073/pnas.0508487102.PMCID: PMC1276113 Corrects: Takeshi Nishimura, et al. Descent of the larynx in chimpanzee infants. Proc Natl Acad Sci U S A. 2003 June 10; 100(12): 6930–6933. |
