| | This journal provides immediate access to some articles. Commentaries Closing the gaps in kinetoplast DNA network replication Michele M. Klingbeil and Paul T. Englund PMCID: PMC384744 Unzipping the mysteries of amyloid fiber formation Andrew D. Miranker PMCID: PMC384745 Extending molecular modeling methodology to study insertion of membrane nanopores Aleksij Aksimentiev and Klaus Schulten PMCID: PMC384746 Unraveling the mystery of Nod factor signaling by a genomic approach in Medicago trunactula Douglas R. Cook PMCID: PMC384747 Physical Sciences Applied Mathematics Response of complex networks to stimuli Yaneer Bar-Yam and Irving R. Epstein PMCID: PMC384748 Chemistry The structure of zetekitoxin AB, a saxitoxin analog from the Panamanian golden frog Atelopus zeteki: A potent sodium-channel blocker Mari Yotsu-Yamashita, Yong H. Kim, Samuel C. Dudley, Jr., Gaurav Choudhary, Arnold Pfahnl, Yasukatsu Oshima, and John W. Daly PMCID: PMC384749 Mathematics The strong Nagata conjecture Ualbai U. Umirbaev and Jie-Tai Yu PMCID: PMC384750 Biological Sciences Anthropology Morphometrics and hominoid phylogeny: Support for a chimpanzee–human clade and differentiation among great ape subspecies Charles A. Lockwood, William H. Kimbel, and John M. Lynch PMCID: PMC384751 Biochemistry From the Cover:
Mitochondrial DNA ligase in Crithidia fasciculata Krishna Murari Sinha, Jane C. Hines, Nicholas Downey, and Dan S. Ray PMCID: PMC384752 Molecular clamp mechanism of substrate binding by hydrophobic coiled-coil residues of the archaeal chaperone prefoldin Victor F. Lundin, Peter C. Stirling, Juan Gomez-Reino, Jill C. Mwenifumbo, Jennifer M. Obst, José M. Valpuesta, and Michel R. Leroux PMCID: PMC384753 The arginine finger of bacteriophage T7 gene 4 helicase: Role in energy coupling Donald J. Crampton, Shenyuan Guo, Donald E. Johnson, and Charles C. Richardson PMCID: PMC384754 Purification and architecture of the ubiquitous Wave complex Alexis Gautreau, Hsin-yi H. Ho, Jiaxu Li, Hanno Steen, Steven P. Gygi, and Marc W. Kirschner PMCID: PMC384755 Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum Puran S. Sijwali and Philip J. Rosenthal PMCID: PMC384756 Characterization of a regiospecific epivancosaminyl transferase GtfA and enzymatic reconstitution of the antibiotic chloroeremomycin Wei Lu, Markus Oberthür, Catherine Leimkuhler, Junhua Tao, Daniel Kahne, and Christopher T. Walsh PMCID: PMC384757 The role of RNA polymerase σ subunit in promoter-independent initiation of transcription Nikolay Zenkin and Konstantin Severinov PMCID: PMC384758 Functional association between Wwox tumor suppressor protein and p73, a p53 homolog Rami I. Aqeilan, Yuri Pekarsky, Juan J. Herrero, Alexey Palamarchuk, Jean Letofsky, Teresa Druck, Francesco Trapasso, Shuang-Yin Han, Gerry Melino, Kay Huebner, and Carlo M. Croce PMCID: PMC384759 Mammalian GLD-2 homologs are poly(A) polymerases Jae Eun Kwak, Liaoteng Wang, Scott Ballantyne, Judith Kimble, and Marvin Wickens PMCID: PMC384760 Isoprenoid biosynthesis in the diatoms Rhizosolenia setigera (Brightwell) and Haslea ostrearia (Simonsen) Guillaume Massé, Simon T. Belt, Steven J. Rowland, and Michel Rohmer PMCID: PMC384761 M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFβ-TrCP Nobumoto Watanabe, Harumi Arai, Yoshifumi Nishihara, Makoto Taniguchi, Naoko Watanabe, Tony Hunter, and Hiroyuki Osada PMCID: PMC384762 Biophysics The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation Kyung H. Choi, James M. Groarke, Dorothy C. Young, Richard J. Kuhn, Janet L. Smith, Daniel C. Pevear, and Michael G. Rossmann PMCID: PMC384763 From the Cover:
Understanding nature's design for a nanosyringe Carlos F. Lopez, Steve O. Nielsen, Preston B. Moore, and Michael L. Klein PMCID: PMC384764 Exploring amyloid formation by a de novo design Richard A. Kammerer, Dirk Kostrewa, Jesús Zurdo, Andreas Detken, Carlos García-Echeverría, Janelle D. Green, Shirley A. Müller, Beat H. Meier, Fritz K. Winkler, Christopher M. Dobson, and Michel O. Steinmetz PMCID: PMC384765 Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity Delphine Bichet, Yu-Fung Lin, Christian A. Ibarra, Cindy Shen Huang, B. Alexander Yi, Yuh Nung Jan, and Lily Yeh Jan PMCID: PMC384766 Percolation and criticality in a mitochondrial network Miguel A. Aon, Sonia Cortassa, and Brian O'Rourke PMCID: PMC384767 Cell Biology Partially redundant functions of SRC-1 and TIF2 in postnatal survival and male reproduction Manuel Mark, Hiromi Yoshida-Komiya, Martine Gehin, Lan Liao, Ming-Jer Tsai, Bert W. O'Malley, Pierre Chambon, and Jianming Xu PMCID: PMC384768 Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells Loren Michel, Elena Diaz-Rodriguez, Gopeshwar Narayan, Eva Hernando, Vundavalli V. V. S. Murty, and Robert Benezra PMCID: PMC384769 Regulation of cyclin-dependent kinase activity during mitotic exit and maintenance of genome stability by p21, p27, and p107 Taku Chibazakura, Seth G. McGrew, Jonathan A. Cooper, Hirofumi Yoshikawa, and James M. Roberts PMCID: PMC384770 A transgenic mouse model of metastatic carcinoma involving transdifferentiation of a gastric epithelial lineage progenitor to a neuroendocrine phenotype Andrew J. Syder, Sherif M. Karam, Jason C. Mills, Joseph E. Ippolito, Habib R. Ansari, Vidya Farook, and Jeffrey I. Gordon PMCID: PMC384771 Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair Chang-Goo Huh, Valentina M. Factor, Aránzazu Sánchez, Koichi Uchida, Elizabeth A. Conner, and Snorri S. Thorgeirsson PMCID: PMC384772 Caenorhabditis elegans functional orthologue of human protein h-mucolipin-1 is required for lysosome biogenesis Sebastian Treusch, Sarah Knuth, Susan A. Slaugenhaupt, Ehud Goldin, Barth D. Grant, and Hanna Fares PMCID: PMC384773 Developmental Biology Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling Wei Liu, Jennifer Selever, Degang Wang, Mei-Fang Lu, Kelvin A. Moses, Robert J. Schwartz, and James F. Martin PMCID: PMC384774 Self-renewal capacity is a widespread property of various types of neural crest precursor cells Andréa Trentin, Corinne Glavieux-Pardanaud, Nicole M. Le Douarin, and Elisabeth Dupin PMCID: PMC384775 Ecology The ecological and evolutionary consequences of sperm chemoattraction Jeffrey A. Riffell, Patrick J. Krug, and Richard K. Zimmer PMCID: PMC384776 Evolution Body plan evolution of ascomycetes, as inferred from an RNA polymerase II phylogeny Yajuan J. Liu and Benjamin D. Hall PMCID: PMC384777 Evolutionary stability of DNA uptake signal sequences in the Pasteurellaceae M. Bakkali, T.-Y. Chen, H. C. Lee, and R. J. Redfield PMCID: PMC384778 Genetics Tying synaptonemal complex initiation to the formation and programmed repair of DNA double-strand breaks Kiersten A. Henderson and Scott Keeney PMCID: PMC384779 Yeast genome-wide drug-induced haploinsufficiency screen to determine drug mode of action Kristin Baetz, Lianne McHardy, Ken Gable, Tamsin Tarling, Delphine Rebérioux, Jenny Bryan, Raymond J. Andersen, Teresa Dunn, Phil Hieter, and Michel Roberge PMCID: PMC384780 Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults Julio Licinio, Sinan Caglayan, Metin Ozata, Bulent O. Yildiz, Patricia B. de Miranda, Fiona O'Kirwan, Robert Whitby, Liyin Liang, Pinchas Cohen, Shalender Bhasin, Ronald M. Krauss, Johannes D. Veldhuis, Anthony J. Wagner, Alex M. DePaoli, Samuel M. McCann, and Ma-Li Wong PMCID: PMC384781 Genome-wide identification of DNaseI hypersensitive sites using active chromatin sequence libraries Peter J. Sabo, Richard Humbert, Michael Hawrylycz, James C. Wallace, Michael O. Dorschner, Michael McArthur, and John A. Stamatoyannopoulos PMCID: PMC384782 Peroxisome proliferator-activated receptor γ is required in mature white and brown adipocytes for their survival in the mouse Takeshi Imai, Reiko Takakuwa, Sandra Marchand, Emilie Dentz, Jean-Marc Bornert, Nadia Messaddeq, Olivia Wendling, Manuel Mark, Béatrice Desvergne, Walter Wahli, Pierre Chambon, and Daniel Metzger PMCID: PMC384783 Circle-to-circle amplification for precise and sensitive DNA analysis Fredrik Dahl, Johan Banér, Mats Gullberg, Maritha Mendel-Hartvig, Ulf Landegren, and Mats Nilsson PMCID: PMC384784 A regulator that inhibits transcription by targeting an intersubunit interaction of the RNA polymerase holoenzyme B. D. Gregory, B. E. Nickels, S. J. Garrity, E. Severinova, L. Minakhin, R. J. Bieber Urbauer, J. L. Urbauer, T. Heyduk, K. Severinov, and A. Hochschild PMCID: PMC384785 Immunology Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria Frank A. W. Verreck, Tjitske de Boer, Dennis M. L. Langenberg, Marieke A. Hoeve, Matthijs Kramer, Elena Vaisberg, Robert Kastelein, Arend Kolk, René de Waal-Malefyt, and Tom H. M. Ottenhoff PMCID: PMC384786 Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-κB activation Marc Schmidt-Supprian, Jane Tian, Ethan P. Grant, Manolis Pasparakis, René Maehr, Huib Ovaa, Hidde L. Ploegh, Anthony J. Coyle, and Klaus Rajewsky PMCID: PMC384787 TGF-β regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes Yufeng Peng, Yasmina Laouar, Ming O. Li, E. Allison Green, and Richard A. Flavell PMCID: PMC384788 Medical Sciences Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells Wen-Chien Chou, Chunfa Jie, Andrew A. Kenedy, Richard J. Jones, Michael A. Trush, and Chi V. Dang PMCID: PMC384789 A zebrafish model for pyruvate dehydrogenase deficiency: Rescue of neurological dysfunction and embryonic lethality using a ketogenic diet Michael R. Taylor, James B. Hurley, Heather A. Van Epps, and Susan E. Brockerhoff PMCID: PMC384790 Highly attenuated smallpox vaccine protects mice with and without immune deficiencies against pathogenic vaccinia virus challenge Linda S. Wyatt, Patricia L. Earl, Leigh Anne Eller, and Bernard Moss PMCID: PMC384791 Microbiology From the Cover:
Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota John F. Rawls, Buck S. Samuel, and Jeffrey I. Gordon PMCID: PMC384792 The temporal expression profile of Mycobacterium tuberculosis infection in mice Adel M. Talaat, Rick Lyons, Susan T. Howard, and Stephen Albert Johnston PMCID: PMC384793 Mycobacterial polyketide-associated proteins are acyltransferases: Proof of principle with Mycobacterium tuberculosis PapA5 Kenolisa C. Onwueme, Julian A. Ferreras, John Buglino, Christopher D. Lima, and Luis E. N. Quadri PMCID: PMC384794 Salmonella typhi encodes a functional cytolethal distending toxin that is delivered into host cells by a bacterial-internalization pathway Erik Haghjoo and Jorge E. Galán PMCID: PMC384795 Human and avian influenza viruses target different cell types in cultures of human airway epithelium Mikhail N. Matrosovich, Tatyana Y. Matrosovich, Thomas Gray, Noel A. Roberts, and Hans-Dieter Klenk PMCID: PMC384796 Inhibition of Epstein-Barr virus-induced growth proliferation by a nuclear antigen EBNA2-TAT peptide Christopher J. Farrell, Jae Myun Lee, Eui-Cheol Shin, Marek Cebrat, Philip A. Cole, and S. Diane Hayward PMCID: PMC384797 Temperature dependence of metabolic rates for microbial growth, maintenance, and survival P. Buford Price and Todd Sowers PMCID: PMC384798 Neuroscience Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI Michael D. Greicius, Gaurav Srivastava, Allan L. Reiss, and Vinod Menon PMCID: PMC384799 Proteomic mapping provides powerful insights into functional myelin biology Christopher M. Taylor, Cecilia B. Marta, Robert J. Claycomb, David K. Han, Matthew N. Rasband, Timothy Coetzee, and Steven E. Pfeiffer PMCID: PMC384800 From the Cover:
Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice Michihiro Mieda, Jon T. Willie, Junko Hara, Christopher M. Sinton, Takeshi Sakurai, and Masashi Yanagisawa PMCID: PMC384801 Chaos may enhance information transmission in the inferior olive Nicolas Schweighofer, Kenji Doya, Hidekazu Fukai, Jean Vianney Chiron, Tetsuya Furukawa, and Mitsuo Kawato PMCID: PMC384802 Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation Qian Gao, Michael J. Wolfgang, Susanne Neschen, Katsutaro Morino, Tamas L. Horvath, Gerald I. Shulman, and Xin-Yuan Fu PMCID: PMC384803 Behavioral impairments caused by injections of the protein synthesis inhibitor anisomycin after contextual retrieval reverse with time K. Matthew Lattal and Ted Abel PMCID: PMC384804 Pharmacology The structure of zetekitoxin AB, a saxitoxin analog from the Panamanian golden frog Atelopus zeteki: A potent sodium-channel blocker Mari Yotsu-Yamashita, Yong H. Kim, Samuel C. Dudley, Jr., Gaurav Choudhary, Arnold Pfahnl, Yasukatsu Oshima, and John W. Daly PMCID: PMC384749 Quantitative analysis of the formation and diffusion of A1-adenosine receptor-antagonist complexes in single living cells S. J. Briddon, R. J. Middleton, Y. Cordeaux, F. M. Flavin, J. A. Weinstein, M. W. George, B. Kellam, and S. J. Hill PMCID: PMC384805 Physiology Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor Yuxiang Sun, Pei Wang, Hui Zheng, and Roy G. Smith PMCID: PMC384806 Relaxin regulation of endometrial structure and function in the rhesus monkey Laura T. Goldsmith, Gerson Weiss, Smita Palejwala, Tony M. Plant, Andrea Wojtczuk, W. Clark Lambert, Nael Ammur, Debra Heller, Joan H. Skurnick, Dean Edwards, and Donna M. Cole PMCID: PMC384807 Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins Kozue Yamauchi, Tatemitsu Rai, Katsuki Kobayashi, Eisei Sohara, Tatsunori Suzuki, Tomohiro Itoh, Shin Suda, Atsushi Hayama, Sei Sasaki, and Shinichi Uchida PMCID: PMC384808 Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY3-36 B. G. Challis, A. P. Coll, G. S. H. Yeo, S. B. Pinnock, S. L. Dickson, R. R. Thresher, J. Dixon, D. Zahn, J. J. Rochford, A. White, R. L. Oliver, G. Millington, S. A. Aparicio, W. H. Colledge, A. P. Russ, M. B. Carlton, and S. O'Rahilly PMCID: PMC384809 Plant Biology From the Cover:
A Ca2+/calmodulin-dependent protein kinase required for symbiotic nodule development: Gene identification by transcript-based cloning Raka M. Mitra, Cynthia A. Gleason, Anne Edwards, James Hadfield, J. Allan Downie, Giles E. D. Oldroyd, and Sharon R. Long PMCID: PMC384810 WIN1, a transcriptional activator of epidermal wax accumulation in Arabidopsis Pierre Broun, Patricia Poindexter, Erin Osborne, Cai-Zhong Jiang, and José Luis Riechmann PMCID: PMC384811 A latitudinal cline in flowering time in Arabidopsis thaliana modulated by the flowering time gene FRIGIDA John R. Stinchcombe, Cynthia Weinig, Mark Ungerer, Kenneth M. Olsen, Charlotte Mays, Solveig S. Halldorsdottir, Michael D. Purugganan, and Johanna Schmitt PMCID: PMC384812 Corrections Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4718. doi: 10.1073/pnas.0401128101.PMCID: PMC384813 Corrects: Teresa Laragione, et al. Redox regulation of surface protein thiols: Identification of integrin α-4 as a molecular target by using redox proteomics. Proc Natl Acad Sci U S A. 2003 December 9; 100(25): 14737–14741. Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4718. doi: 10.1073/pnas.0400811101.PMCID: PMC384814 Corrects: Joseph Ziegelbauer, et al. Myc-interacting protein 1 target gene profile: A link to microtubules, extracellular signal-regulated kinase, and cell growth. Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 458–463. Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4718. doi: 10.1073/pnas.0401134101.PMCID: PMC384815 Corrects: Elizabeth M. Boon, et al. DNA-mediated charge transport for DNA repair. Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 12543–12547. Proc Natl Acad Sci U S A. 2004 March 30; 101(13): 4718–4719. doi: 10.1073/pnas.0400841101.PMCID: PMC384816 Corrects: Vaishali Parikh, et al. A strabismus susceptibility locus on chromosome 7p. Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12283–12288. |
