| | This journal provides immediate access to some articles. In This Issue Proc Natl Acad Sci U S A. 2005 April 26; 102(17): 5899–5900. doi: 10.1073/iti1705102.PMCID: PMC1087967 Commentaries A model of intracellular organization Gary J. Pielak PMCID: PMC1087939 Symmetrical recognition of cellular DNA target sequences during retroviral integration Duane P. Grandgenett PMCID: PMC1087955 PNAS Classic Article Perspective: How restriction enzymes became the workhorses of molecular biology Richard J. Roberts PMCID: PMC1087929 Classics: Danna and Nathans: Restriction enzymes and the boon to modern molecular biology Christen Brownlee PMCID: PMC1087965 Biography INAUGURAL ARTICLE by a Recently Elected Academy Member: Biography of Kathryn V. Anderson Bijal Trivedi PMCID: PMC1087943 Physical Sciences Chemistry From the Cover:
Dynamic microcompartmentation in synthetic cells M. Scott Long, Clinton D. Jones, Marcus R. Helfrich, Lauren K. Mangeney-Slavin, and Christine D. Keating PMCID: PMC1087917 Four-color DNA sequencing by synthesis on a chip using photocleavable fluorescent nucleotides Tae Seok Seo, Xiaopeng Bai, Dae Hyun Kim, Qinglin Meng, Shundi Shi, Hameer Ruparel, Zengmin Li, Nicholas J. Turro, and Jingyue Ju PMCID: PMC1087949 Design and synthesis of a 3′-O-allyl photocleavable fluorescent nucleotide as a reversible terminator for DNA sequencing by synthesis Hameer Ruparel, Lanrong Bi, Zengmin Li, Xiaopeng Bai, Dae Hyun Kim, Nicholas J. Turro, and Jingyue Ju PMCID: PMC1087948 Chemistry Gelation-driven component selection in the generation of constitutional dynamic hydrogels based on guanine-quartet formation Nampally Sreenivasachary and Jean-Marie Lehn PMCID: PMC1087938 Supramolecular blueprint approach to metal-coordinated capsules Robert M. McKinlay, Gareth W. V. Cave, and Jerry L. Atwood PMCID: PMC1087908 Mathematics Evidence of singularities for a family of contour dynamics equations Diego Córdoba, Marco A. Fontelos, Ana M. Mancho, and Jose L. Rodrigo PMCID: PMC1087950 Biological Sciences Four-color DNA sequencing by synthesis on a chip using photocleavable fluorescent nucleotides Tae Seok Seo, Xiaopeng Bai, Dae Hyun Kim, Qinglin Meng, Shundi Shi, Hameer Ruparel, Zengmin Li, Nicholas J. Turro, and Jingyue Ju PMCID: PMC1087949 Design and synthesis of a 3′-O-allyl photocleavable fluorescent nucleotide as a reversible terminator for DNA sequencing by synthesis Hameer Ruparel, Lanrong Bi, Zengmin Li, Xiaopeng Bai, Dae Hyun Kim, Nicholas J. Turro, and Jingyue Ju PMCID: PMC1087948 Applied Biological Sciences Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation Benjamin G. Keselowsky, David M. Collard, and Andrés J. García PMCID: PMC1087905 Biochemistry A mutation in T7 RNA polymerase that facilitates promoter clearance Jean Guillerez, Pascal J. Lopez, Florence Proux, Hélène Launay, and Marc Dreyfus PMCID: PMC1087904 The human Kv1.1 channel is palmitoylated, modulating voltage sensing: Identification of a palmitoylation consensus sequence Rose A. Gubitosi-Klug, David J. Mancuso, and Richard W. Gross PMCID: PMC1087951 Scanning the human proteome for calmodulin-binding proteins Xinchun Shen, C. Alexander Valencia, Jack Szostak, Biao Dong, and Rihe Liu PMCID: PMC1087907 Structural basis for the interaction of Asf1 with histone H3 and its functional implications Florence Mousson, Aurélie Lautrette, Jean-Yves Thuret, Morgane Agez, Régis Courbeyrette, Béatrice Amigues, Emmanuelle Becker, Jean-Michel Neumann, Raphaël Guerois, Carl Mann, and Françoise Ochsenbein PMCID: PMC1087920 Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase Mindy I. Davis, Melanie J. Bennett, Leonard M. Thomas, and Pamela J. Bjorkman PMCID: PMC556220 Reversible redox-dependent modulation of mitochondrial aconitase and proteolytic activity during in vivo cardiac ischemia/reperfusion Anne-Laure Bulteau, Kathleen C. Lundberg, Masao Ikeda-Saito, Grazia Isaya, and Luke I. Szweda PMCID: PMC1087934 Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements Arvind Ramanathan, Connie Wang, and Stuart L. Schreiber PMCID: PMC1087961 Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells Sangkil Nam, Ralf Buettner, James Turkson, Donghwa Kim, Jin Q. Cheng, Stephan Muehlbeyer, Frankie Hippe, Sandra Vatter, Karl-Heinz Merz, Gerhard Eisenbrand, and Richard Jove PMCID: PMC1087919 Biophysics Semipermeable lipid bilayers exhibit diastereoselectivity favoring ribose M. G. Sacerdote and J. W. Szostak PMCID: PMC556129 From the Cover:
Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors Anna Codina, James D. Love, Yun Li, Mitchell A. Lazar, David Neuhaus, and John W. R. Schwabe PMCID: PMC1087922 Folding events in the 21-30 region of amyloid β-protein (Aβ) studied in silico Jose M. Borreguero, Brigita Urbanc, Noel D. Lazo, Sergey V. Buldyrev, David B. Teplow, and H. Eugene Stanley PMCID: PMC1087952 Cell Biology Implications of the serine protease HtrA1 in amyloid precursor protein processing Sandra Grau, Alfonso Baldi, Rossana Bussani, Xiaodan Tian, Raluca Stefanescu, Michael Przybylski, Peter Richards, Simon A. Jones, Viji Shridhar, Tim Clausen, and Michael Ehrmann PMCID: PMC1087941 G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the β-catenin pathway Ming Yang, Wendy W. Zhong, Neelam Srivastava, Anthony Slavin, Jianxin Yang, Timothy Hoey, and Songzhu An PMCID: PMC1087935 Ecology Ecological controls on water-cycle response to climate variability in deserts B. R. Scanlon, D. G. Levitt, R. C. Reedy, K. E. Keese, and M. J. Sully PMCID: PMC1087913 Evolution From the Cover:
Evolutionary dynamics of olfactory receptor genes in fishes and tetrapods Yoshihito Niimura and Masatoshi Nei PMCID: PMC1087945 Genetic variance in female condition predicts indirect genetic variance in male sexual display traits Donna Petfield, Stephen F. Chenoweth, Howard D. Rundle, and Mark W. Blows PMCID: PMC1087918 Genetics INAUGURAL ARTICLE by a Recently Elected Academy Member: Analysis of mouse embryonic patterning and morphogenesis by forward genetics María J. García-García, Jonathan T. Eggenschwiler, Tamara Caspary, Heather L. Alcorn, Michael R. Wyler, Danwei Huangfu, Andrew S. Rakeman, Jeffrey D. Lee, Evan H. Feinberg, John R. Timmer, and Kathryn V. Anderson PMCID: PMC1087930 Gain-of-function amino acid substitutions drive positive selection of FGFR2 mutations in human spermatogonia Anne Goriely, Gilean A. T. McVean, Ans M. M. van Pelt, Anthony W. O'Rourke, Steven A. Wall, Dirk G. de Rooij, and Andrew O. M. Wilkie PMCID: PMC1087921 Rare creation of recombinant mtDNA haplotypes in mammalian tissues Akitsugu Sato, Kazuto Nakada, Miho Akimoto, Kaori Ishikawa, Tomoko Ono, Hiroshi Shitara, Hiromichi Yonekawa, and Jun-Ichi Hayashi PMCID: PMC1087914 Germ cell mutagenesis in medaka fish after exposures to high-energy cosmic ray nuclei: A human model Atsuko Shimada, Akihiro Shima, Kumie Nojima, Yo Seino, and Richard B. Setlow PMCID: PMC1087928 Immunology Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia David M. Langenau, Hui Feng, Stephane Berghmans, John P. Kanki, Jeffery L. Kutok, and A. Thomas Look PMCID: PMC1087915 Effector CD8+ T cells recovered from an influenza pneumonia differentiate to a state of focused gene expression Dana R. Marshall, Elvia Olivas, Samita Andreansky, Nicole L. La Gruta, Geoff A. Neale, Astrid Gutierrez, David G. Wichlan, Suzette Wingo, Cheng Cheng, Peter C. Doherty, and Stephen J. Turner PMCID: PMC1087947 Medical Sciences Absence of a desmopressin response after therapeutic expression of factor VIII in hemophilia A dogs with liver-directed neonatal gene therapy Lingfei Xu, Timothy C. Nichols, Rita Sarkar, Stephanie McCorquodale, Dwight A. Bellinger, and Katherine P. Ponder PMCID: PMC1087916 Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice Aimin Xu, Michael C. Lam, Kok Weng Chan, Yu Wang, Jialiang Zhang, Ruby L. C. Hoo, Jian Yu Xu, Baoying Chen, Wing-Sun Chow, Annette W. K. Tso, and Karen S. L. Lam PMCID: PMC1087912 From the Cover:
The gene expression signatures of melanoma progression Christopher Haqq, Mehdi Nosrati, Daniel Sudilovsky, Julia Crothers, Daniel Khodabakhsh, Brian L. Pulliam, Scot Federman, James R. Miller, III, Robert E. Allen, Mark I. Singer, Stanley P. L. Leong, Britt-Marie Ljung, Richard W. Sagebiel, and Mohammed Kashani-Sabet PMCID: PMC1087936 Protein fibrils in nature can enhance amyloid protein A amyloidosis in mice: Cross-seeding as a disease mechanism Katarzyna Lundmark, Gunilla T. Westermark, Arne Olsén, and Per Westermark PMCID: PMC1087940 Microbiology Symmetrical base preferences surrounding HIV-1, avian sarcoma/leukosis virus, and murine leukemia virus integration sites Alexander G. Holman and John M. Coffin PMCID: PMC1087937 Direct activation of fission yeast adenylate cyclase by the Gpa2 Gα of the glucose signaling pathway F. Douglas Ivey and Charles S. Hoffman PMCID: PMC1087962 A polymerization-depolymerization model that accurately generates the self-sustained oscillatory system involved in bacterial division site placement Donald A. Drew, Mary J. Osborn, and Lawrence I. Rothfield PMCID: PMC1087953 Self-limiting nature of seasonal cholera epidemics: Role of host-mediated amplification of phage Shah M. Faruque, M. Johirul Islam, Qazi Shafi Ahmad, A. S. G. Faruque, David A. Sack, G. Balakrish Nair, and John J. Mekalanos PMCID: PMC1087956 Neuroscience Identification of network-level coding units for real-time representation of episodic experiences in the hippocampus Longnian Lin, Remus Osan, Shy Shoham, Wenjun Jin, Wenqi Zuo, and Joe Z. Tsien PMCID: PMC1087910 From the Cover:
Synaptic vesicle recycling studied in transgenic mice expressing synaptopHluorin Zhiying Li, Juan Burrone, William J. Tyler, Kenichi N. Hartman, Dinu F. Albeanu, and Venkatesh N. Murthy PMCID: PMC1087931 Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter Christine I. Nam and Lu Chen PMCID: PMC1087954 Aneuploid neurons are functionally active and integrated into brain circuitry M. A. Kingsbury, B. Friedman, M. J. McConnell, S. K. Rehen, A. H. Yang, D. Kaushal, and J. Chun PMCID: PMC1087909 Neuronal migration in the murine rostral migratory stream requires serum response factor Siegfried Alberti, Sven M. Krause, Oliver Kretz, Ulrike Philippar, Thomas Lemberger, Emilio Casanova, Franziska F. Wiebel, Heinz Schwarz, Michael Frotscher, Günther Schütz, and Alfred Nordheim PMCID: PMC1087932 Zinc inhibition of γ-aminobutyric acid transporter 4 (GAT4) reveals a link between excitatory and inhibitory neurotransmission Einav Cohen-Kfir, William Lee, Sepehr Eskandari, and Nathan Nelson PMCID: PMC556128 Fluorescence measurements reveal stoichiometry of K+ channels formed by modulatory and delayed rectifier α-subunits Daniel Kerschensteiner, Florentina Soto, and Martin Stocker PMCID: PMC1087924 Glutamate induces the rapid formation of spine head protrusions in hippocampal slice cultures David A. Richards, José Maria Mateos, Sylvain Hugel, Vincenzo de Paola, Pico Caroni, Beat H. Gähwiler, and R. Anne McKinney PMCID: PMC556130 Adaptation without parameter change: Dynamic gain control in motion detection Alexander Borst, Virginia L. Flanagin, and Haim Sompolinsky PMCID: PMC1087925 Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success Samuel G. Jacobson, Tomas S. Aleman, Artur V. Cideciyan, Alexander Sumaroka, Sharon B. Schwartz, Elizabeth A. M. Windsor, Elias I. Traboulsi, Elise Heon, Steven J. Pittler, Ann H. Milam, Albert M. Maguire, Krzysztof Palczewski, Edwin M. Stone, and Jean Bennett PMCID: PMC1087926 Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas Damián Refojo, Carlos Echenique, Marianne B. Müller, Johannes M. H. M. Reul, Jan M. Deussing, Wolfgang Wurst, Inge Sillaber, Marcelo Paez-Pereda, Florian Holsboer, and Eduardo Arzt PMCID: PMC1087957 Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens Jeffrey W. Dalley, Kristjan Lääne, David E. H. Theobald, Hannah C. Armstrong, Philip R. Corlett, Yogita Chudasama, and Trevor W. Robbins PMCID: PMC556132 Pharmacology A brain detoxifying enzyme for organophosphorus nerve poisons Daniel K. Nomura, Donmienne Leung, Kyle P. Chiang, Gary B. Quistad, Benjamin F. Cravatt, and John E. Casida PMCID: PMC1087944 Structural basis for antagonism and resistance of bicalutamide in prostate cancer Casey E. Bohl, Wenqing Gao, Duane D. Miller, Charles E. Bell, and James T. Dalton PMCID: PMC1087923 Physiology Deletion of PPARγ in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance Julie R. Jones, Cordelia Barrick, Kyoung-Ah Kim, Jill Lindner, Bertrand Blondeau, Yuka Fujimoto, Masakazu Shiota, Robert A. Kesterson, Barbara B. Kahn, and Mark A. Magnuson PMCID: PMC556131 The rapid release of corticosterone from the adrenal induced by ACTH is mediated by nitric oxide acting by prostaglandin E2 Claudia E. Mohn, Javier Fernandez-Solari, Andrea De Laurentiis, Juan Pablo Prestifilippo, Carolina de la Cal, Richard Funk, Stefan R. Bornstein, Samuel M. McCann, and Valeria Rettori PMCID: PMC1087960 Plant Biology A coiled-coil interaction mediates cauliflower mosaic virus cell-to-cell movement Livia Stavolone, Maria Elena Villani, Denis Leclerc, and Thomas Hohn PMCID: PMC1087906 Dual targeting of the protein disulfide isomerase RB60 to the chloroplast and the endoplasmic reticulum Alexander Levitan, Tova Trebitsh, Vladimir Kiss, Yaron Pereg, Inbal Dangoor, and Avihai Danon PMCID: PMC1087927 Social Sciences Anthropology Global archaeological evidence for proboscidean overkill Todd Surovell, Nicole Waguespack, and P. Jeffrey Brantingham PMCID: PMC1087946 Corrections Proc Natl Acad Sci U S A. 2005 April 26; 102(17): 6237. doi: 10.1073/pnas.0502360102.PMCID: PMC1087963 Corrects: Shuen-Iu Hung, et al. HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. Proc Natl Acad Sci U S A. 2005 March 15; 102(11): 4134–4139. Proc Natl Acad Sci U S A. 2005 April 26; 102(17): 6237. doi: 10.1073/pnas.0502717102.PMCID: PMC1087964 Corrects: Melissa Marino. INAUGURAL ARTICLE by a Recently Elected Academy Member: Biography of Cornelia I. Bargmann. Proc Natl Acad Sci U S A. 2005 March 1; 102(9): 3181–3183. Proc Natl Acad Sci U S A. 2005 April 26; 102(17): 6238. doi: 10.1073/pnas.0502810102.PMCID: PMC1087966 Corrects: Alexander G. Holman, et al. Symmetrical base preferences surrounding HIV-1, avian sarcoma/leukosis virus, and murine leukemia virus integration sites. Proc Natl Acad Sci U S A. 2005 April 26; 102(17): 6103–6107. |
