EDITORIAL: Old and New Policy Issues at PNAS

Temperature-derivative spectroscopy: a tool for protein dynamics.

C-terminal truncation of the retinoblastoma gene product leads to functional inactivation.

Evidence for additional subunits associated to the mouse interleukin 2 receptor p55/p75 complex.

Involvement of myosin light-chain kinase in endothelial cell retraction.

Stable DNA heteroduplex formation catalyzed by the Escherichia coli RecA protein in the absence of ATP hydrolysis.

Albumin Redhill (-1 Arg, 320 Ala----Thr): a glycoprotein variant of human serum albumin whose precursor has an aberrant signal peptidase cleavage site.

Drosophila glutathione S-transferase 1-1 shares a region of sequence homology with the maize glutathione S-transferase III.

Induction of transcription from the long terminal repeat of Moloney murine sarcoma provirus by UV-irradiation, x-irradiation, and phorbol ester.

Conserved aspartate residues and phosphorylation in signal transduction by the chemotaxis protein CheY.

Maize regulatory gene opaque-2 encodes a protein with a "leucine-zipper" motif that binds to zein DNA.

Molecular dissection of mutations at the heterozygous thymidine kinase locus in mouse lymphoma cells.

Capelli bitableaux and Z-forms of general linear Lie superalgebras.

Interleukin 5 is required for the blood and tissue eosinophilia but not granuloma formation induced by infection with Schistosoma mansoni.

Characterization of a class of nonformylated Enterococcus faecalis-derived neutrophil chemotactic peptides: the sex pheromones.

Do thylakoids really contain phosphatidylcholine?

Fibroblast-mediated acceleration of human epithelial tumor growth in vivo.

Holomorphic curves in surfaces of general type.

Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells.

Transient foreign gene expression in chloroplasts of cultured tobacco cells after biolistic delivery of chloroplast vectors.

Regulation of surface expression of the granulocyte/macrophage colony-stimulating factor receptor in normal human myeloid cells.

Isolation of complementary DNA clones encoding pathogenesis-related proteins P and Q, two acidic chitinases from tobacco.

Bacteriophage P1 cloning system for the isolation, amplification, and recovery of DNA fragments as large as 100 kilobase pairs.

Parathyroid hormone-related peptide gene is expressed in the mammalian central nervous system.

Phorbol ester induces photoreceptor-specific degeneration in a Drosophila mutant.

Automatic generation of primary sequence patterns from sets of related protein sequences.

Pasteurella multocida toxin: potent mitogen for cultured fibroblasts.

B-type receptor for platelet-derived growth factor mediates a chemotactic response by means of ligand-induced activation of the receptor protein-tyrosine kinase.

Expression of functional pituitary somatostatin receptors in Xenopus oocytes.

Spectroscopic studies of wild-type and mutant "zinc finger" peptides: determinants of domain folding and structure.

Expression of a cloned streptavidin gene in Escherichia coli.

Higher order nuclear organization: three-dimensional distribution of small nuclear ribonucleoprotein particles.

Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies.

Selectivity of the cleavage/attachment site of phosphatidylinositol-glycan-anchored membrane proteins determined by site-specific mutagenesis at Asp-484 of placental alkaline phosphatase.

Influence of the hinge region on complement activation, C1q binding, and segmental flexibility in chimeric human immunoglobulins.

Surface tension measurements show that chaotropic salting-in denaturants are not just water-structure breakers.

Long-distance activation of the Myc protooncogene by provirus insertion in Mlvi-1 or Mlvi-4 in rat T-cell lymphomas.

Mammalian dihydroorotase: nucleotide sequence, peptide sequences, and evolution of the dihydroorotase domain of the multifunctional protein CAD.

Nonminimum phase non-Gaussian autoregressive processes.

[Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist.

Nerve growth factor receptor immunoreactivity is transiently associated with the subplate neurons of the mammalian cerebral cortex.

Acetylaminofluorene bound to different guanines of the sequence -GGCGCC- is excised with different efficiencies by the UvrABC excision nuclease in a pattern not correlated to the potency of mutation induction.

Defective chlorophyll a/b-binding protein genes in the genome of a homosporous fern.

Evolution of the first metabolic cycles.

Metastable intermediates in myoglobin at low pH.

Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes.

Femtosecond dynamics of energy transfer in B800-850 light-harvesting complexes of Rhodobacter sphaeroides.

Active-site zinc ligands and activated H2O of zinc enzymes.

A single clone of Staphylococcus aureus causes the majority of cases of toxic shock syndrome.

Dopamine receptor gene expression by enkephalin neurons in rat forebrain.

Self-tolerance to HLA focuses the response of immunized HLA-transgenic mice on production of antibody to precise polymorphic HLA alloantigens.

On-line analysis of penicillin blood levels in the live rat by combined microdialysis/fast-atom bombardment mass spectrometry.

Determination of the crystal structure and composition of Li6Be4OH12 by the stochastic method.

gamma-Preprotachykinin-(72-92)-peptide amide: an endogenous preprotachykinin I gene-derived peptide that preferentially binds to neurokinin-2 receptors.

Mouse insulin-responsive glucose transporter gene: characterization of the gene and trans-activation by the CCAAT/enhancer binding protein.

The anterior cingulate cortex mediates processing selection in the Stroop attentional conflict paradigm.

Inhibition by Ca2+ of inositol trisphosphate-mediated Ca2+ liberation: a possible mechanism for oscillatory release of Ca2+.

Type II hereditary angioneurotic edema that may result from a single nucleotide change in the codon for alanine-436 in the C1 inhibitor gene.

Specific high molecular weight mRNAs induced by associative learning in Hermissenda.

Production of abiotic receptors by molecular imprinting of proteins.

Sequence analysis and DNA-protein interactions within the 5' flanking region of the Ca2+/calmodulin-dependent protein kinase II alpha-subunit gene.

Major cold shock protein of Escherichia coli.

Identification of a noncatalytic cGMP-binding domain conserved in both the cGMP-stimulated and photoreceptor cyclic nucleotide phosphodiesterases.

Bovine cone photoreceptor cGMP phosphodiesterase structure deduced from a cDNA clone.

Progastrin expression in mammalian pancreas.

Selective alterations of RNA in rat hippocampus after entorhinal cortex lesioning.

Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicity.

Cytotoxic T-cell precursors with low-level CD8 in the diabetes-prone Biobreeding rat: implications for generation of an autoimmune T-cell repertoire.

Constitutive expression of growth-related mRNAs in proliferating and nonproliferating lung epithelial cells in primary culture: evidence for growth-dependent translational control.

A neutral amino acid change in segment IIS4 dramatically alters the gating properties of the voltage-dependent sodium channel.

Translation of bicistronic viral mRNA in transfected cells: regulation at the level of elongation.

Identification and characterization of a Neisseria gonorrhoeae gene encoding a glycolipid-binding adhesin.

Crystal structure of the antigen-binding fragment of the murine anti-arsonate monoclonal antibody 36-71 at 2.9-A resolution.

The allosteric glycine site of the N-methyl-D-aspartate receptor modulates GABAergic-mediated synaptic events in neonatal rat CA3 hippocampal neurons.

Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.

Specific binding of antigenic peptides to separate alpha and beta chains of class II molecules of the major histocompatibility complex.

GTP-binding Ypt1 protein and Ca2+ function independently in a cell-free protein transport reaction.

Mutations in the bglY gene increase the frequency of spontaneous deletions in Escherichia coli K-12.

Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.

DNA sequences in the rat osteocalcin gene that bind the 1,25-dihydroxyvitamin D3 receptor and confer responsiveness to 1,25-dihydroxyvitamin D3.

Identification of heat shock protein hsp70 homologues in chloroplasts.

Thyroid hormone regulates expression of a transfected human alpha-myosin heavy-chain fusion gene in fetal rat heart cells.

Manganese-dependent disproportionation of hydrogen peroxide in bicarbonate buffer.

Manganese(II) catalyzes the bicarbonate-dependent oxidation of amino acids by hydrogen peroxide and the amino acid-facilitated dismutation of hydrogen peroxide.

Manganese(II)-bicarbonate-mediated catalytic activity for hydrogen peroxide dismutation and amino acid oxidation: detection of free radical intermediates.

Unusual molecular characteristics of a repeat sequence island within a Giemsa-positive band on the mouse X chromosome.

Overexpression of fibronectin induced by diabetes or high glucose: phenomenon with a memory.

Identification of a viral gene encoding a ubiquitin-like protein.

Alteration of cross-bridge kinetics by myosin light chain phosphorylation in rabbit skeletal muscle: implications for regulation of actin-myosin interaction.

Labile disulfide bonds in human placental insulin receptor.

Selectivity of phospholipase C phosphorylation by the epidermal growth factor receptor, the insulin receptor, and their cytoplasmic domains.

A simple model for the immune network.

Genomic RNA of an insect virus directs synthesis of infectious virions in plants.

Expression of human adenosine deaminase in mice reconstituted with retrovirus-transduced hematopoietic stem cells.

Gene imprinting and major histocompatibility complex class I antigen expression in the rat placenta.

Innervation patterns of single physiologically identified geniculocortical axons in the striate cortex of the tree shrew.

Subcellular distribution of an inhalational anesthetic in situ.

Neurons and glia arise from a common progenitor in chicken optic tectum: demonstration with two retroviruses and cell type-specific antibodies.

Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements.

Histidine-94 is the only important histidine residue in the melibiose permease of Escherichia coli.

Human gene transfer: characterization of human tumor-infiltrating lymphocytes as vehicles for retroviral-mediated gene transfer in man.

Bialgebra cohomology, deformations, and quantum groups.

Relation of spontaneous transformation in cell culture to adaptive growth and clonal heterogeneity.

Factors governing helical preference of peptides containing multiple alpha,alpha-dialkyl amino acids.

Tumor trapping of 5-fluorouracil: in vivo 19F NMR spectroscopic pharmacokinetics in tumor-bearing humans and rabbits.

Point substitutions in albumin genetic variants from Asia.