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Sponsored by: |
National Taiwan University Hospital |
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Information provided by: | National Taiwan University Hospital |
ClinicalTrials.gov Identifier: | NCT00745758 |
Extensive research has shown that the big event that leads to the initiation of vasospasm is the release of oxyhemoglobin (blood breakdown product).Depletion of NO synthase (19,20,21) was also noted after SAH.CSF is produced from choroid plexus in the ventricle. If the SAH is too dense, the blood in the subarachnoid space will not easy to be washed out.
Condition |
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Subarachnoid Hemorrhage Vasospasm, Intracranial |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | The Factors Cause Vasospasm After Aneurysmal Subarachnoid Hemorrhage |
CSF
Estimated Enrollment: | 20 |
Study Start Date: | May 2008 |
Estimated Study Completion Date: | September 2008 |
Cerebral vasospasm remains a significant source of morbidity and mortality in patients with subarachnoid hemorrhage (SAH) after an aneurysmal rupture. Despite being a significant source of morbidity and mortality, death and disability from vasospasm have declined from approximately 35% in the early 1970's, to between 15% and 20% in the 1980's to <10% in the 1990's(1,2,3,4).Extensive research has shown that the big event that leads to the initiation of vasospasm is the release of oxyhemoglobin (blood breakdown product)(1,12,13). This mechanism appears to be a multifactorial process that involves the generation of free radicals, lipid peroxidation and activation of protein kinase C as well as phospholipase C and A2 with resultant accumulation of diacylglycerol and the release of endothelin-1(14,15,16,17,18). On the other hand, depletion of NO synthase (19,20,21) was also noted after SAH. Previous reports showed that shunting of CSF through a lumbar drain after an SAH markedly reduces the risk of clinically evident vasospasm and its sequelae, shortens hospital stay, and improves outcome. Its beneficial effects are probably mediated through the removal of spasmogens that exist in the CSF(22). In our preliminary data, we have demonstrated a case with severe vasospasm, CSF was collected both from EVD and lumbar drain. The ADMA level and amount of Nitrate was well correlate with vasospasm and the level was much higher in lumbar drain then EVD. So, we will compared the CSF from EVD and lumbar puncture to see which factor is correlate with vasospasm.
Ages Eligible for Study: | 18 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
patient of spontaneous SAH
Inclusion Criteria:
Exclusion Criteria:
Contact: Kuo-Chuan Wang, MD | 886-223123456 ext 5077 | wang081466@yahoo.com.tw |
Taiwan | |
devision of neurosurgery, National taiwan university hospital | Recruiting |
Taipei, Taiwan, 112 | |
Contact: Kuo-Chuan Wang, MD 886223123456 wang081466@yahoo.com.tw | |
Principal Investigator: Kuo-Chuan Wang, MD |
Principal Investigator: | Kuo-Chuan Wang, MD | NTUH |
Responsible Party: | Devision of neurosurgery ( Kuo-Chuan Wang ) |
Study ID Numbers: | 200803080R |
Study First Received: | August 31, 2008 |
Last Updated: | September 2, 2008 |
ClinicalTrials.gov Identifier: | NCT00745758 |
Health Authority: | Taiwan: Department of Health |
SAH, vasospasm, ADMA |
Vascular Diseases Subarachnoid Hemorrhage Central Nervous System Diseases Intracranial Hemorrhages |
Brain Diseases Hemorrhage Cerebrovascular Disorders Vasospasm, Intracranial |
Pathologic Processes Nervous System Diseases Cardiovascular Diseases |