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Sponsored by: |
GlaxoSmithKline |
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Information provided by: | GlaxoSmithKline |
ClinicalTrials.gov Identifier: | NCT00517946 |
The purpose of this study is to establish whether MRI scanning is a sensitive measure of the effects of existing drug treatments on nasal dimensions following challenge with intranasal allergen in subjects with hayfever. If successful this technique could be applied to increase confidence for internal decision making and ultimately may be used to assess how effective a new drug treatment is.
Condition | Intervention | Phase |
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Seasonal Allergic Rhinitis |
Drug: pseudoephedrine hydrochloride Drug: cetirizine hydrochloride |
Phase I |
Study Type: | Interventional |
Study Design: | Diagnostic, Randomized, Single Blind, Crossover Assignment, Pharmacodynamics Study |
Official Title: | An Investigation to Evaluate the Technique of MRI as an Assessment of the Effect of Anti-Allergy Drug Treatment on Internal Nasal and Sinus Mucosal Anatomy Following Intranasal Allergen Challenge in Subjects With Seasonal Allergic Rhinitis. |
Enrollment: | 21 |
Study Start Date: | March 2007 |
Ages Eligible for Study: | 18 Years to 60 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Responsible Party: | GSK ( Study Director ) |
Study ID Numbers: | RES101509 |
Study First Received: | August 15, 2007 |
Last Updated: | October 9, 2008 |
ClinicalTrials.gov Identifier: | NCT00517946 |
Health Authority: | United Kingdom: Medicines and Healthcare Products Regulatory Agency |
MRI, intranasal allergen challenge, seasonal allergic rhinitis (SAR), anti-allergy. |
Pseudoephedrine Otorhinolaryngologic Diseases SARS Rhinitis Cetirizine Histamine Naphazoline Oxymetazoline Hypersensitivity Respiratory Tract Diseases |
Respiratory Tract Infections Guaifenesin Phenylephrine Rhinitis, Allergic, Seasonal Hypersensitivity, Immediate Histamine phosphate Ephedrine Phenylpropanolamine Respiratory Hypersensitivity |
Respiratory System Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Adrenergic Agents Immune System Diseases Sympathomimetics Physiological Effects of Drugs Histamine Agents Anti-Asthmatic Agents Central Nervous System Stimulants Anti-Allergic Agents Cardiovascular Agents |
Nose Diseases Pharmacologic Actions Nasal Decongestants Histamine Antagonists Autonomic Agents Therapeutic Uses Vasoconstrictor Agents Histamine H1 Antagonists Peripheral Nervous System Agents Histamine H1 Antagonists, Non-Sedating Central Nervous System Agents Bronchodilator Agents |