Sex Differences in Gene Expression in Human Adipose Tissue - Full Text View

Sponsors and Collaborators:	University of California, San Diego University of Maryland
Information provided by:	University of California, San Diego
ClinicalTrials.gov Identifier:	NCT00677651

Purpose

This project was created to assess sex differences in adipose tissue gene expression in different locations in the body. The primary objectives are to understand:

The mechanisms of differential body fat distribution in men and women
How body fat distribution is affected by reproductive hormones
The mechanisms linking fat distribution to health risks such as diabetes

Condition	Intervention
Healthy Obesity	Procedure: Adipose Biopsy Procedure: Blood sample Radiation: CT Scan Radiation: DEXA

MedlinePlus related topics: CT Scans Nuclear Scans Obesity

U.S. FDA Resources

Study Type:	Observational
Study Design:	Case-Only, Prospective
Official Title:	Sex Differences in Gene Expression in Human Adipose Tissue

Further study details as provided by University of California, San Diego:

Primary Outcome Measures:

Adipose and blood sampling [ Time Frame: 1 year ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

CT scan and DEXA scan [ Time Frame: 1 year ] [ Designated as safety issue: No ]

Biospecimen Retention: Samples With DNA

Biospecimen Description:

Blood, Fat tissue from abdomen and buttock

Estimated Enrollment:	10
Study Start Date:	April 2008
Estimated Study Completion Date:	April 2009
Estimated Primary Completion Date:	April 2009 (Final data collection date for primary outcome measure)

Groups/Cohorts	Assigned Interventions
1 Five caucasian women	Procedure: Adipose Biopsy Adipose tissue will be sampled from the abdomen and buttock Procedure: Blood sample Blood will be sampled from an IV line Radiation: CT Scan Single image at the level of the liver Radiation: DEXA Whole body scan
2 Five caucasian men	Procedure: Adipose Biopsy Adipose tissue will be sampled from the abdomen and buttock Procedure: Blood sample Blood will be sampled from an IV line Radiation: CT Scan Single image at the level of the liver Radiation: DEXA Whole body scan

Eligibility

Ages Eligible for Study:	20 Years to 35 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

General Population

Criteria

Inclusion Criteria:

Caucasian men and women 20-35 years of age
Lean (BMI less than 25)
Obese (BMI 30-35)

Exclusion Criteria:

Hormonal birth control
Pregnancy
Smokers
History of diabetes, kidney, liver or thyroid disease
History of cancer

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00677651

Contacts

Contact: Marcus A Rosencrantz, M.D.

858-534-8930

mrosencrantz@ucsd.edu

Locations

United States, California
UCSD	Recruiting
La Jolla, California, United States, 91963-0063
Contact: Rosencrantz mrosencrantz@ucsd.edu

Sponsors and Collaborators

University of California, San Diego

University of Maryland

Investigators

Principal Investigator:

Jeffrey Chang, M.D.

UCSD

More Information

Responsible Party:	University of California, San Diego ( R. Jeffrey Chang, MD )
Study ID Numbers:	070668
Study First Received:	May 12, 2008
Last Updated:	May 12, 2008
ClinicalTrials.gov Identifier:	NCT00677651
Health Authority:	United States: Institutional Review Board

Keywords provided by University of California, San Diego:

adipose
lean
obese
overweight
healthy

Study placed in the following topic categories:

Body Weight
Signs and Symptoms
Obesity
Nutrition Disorders

Overnutrition
Overweight
Healthy

ClinicalTrials.gov processed this record on January 14, 2009