Diagnostic Value of Hyperbilirubinaemia as a Predictive Factor for Appendiceal Perforation in Acute Appendicitis - Full Text View

Sponsored by:	Ruhr University of Bochum
Information provided by:	Ruhr University of Bochum
ClinicalTrials.gov Identifier:	NCT00677417

Purpose

The values of laboratory examinations which are useful for the diagnoses of appendicitis are white blood cell count (WBC), C-reactive protein (CRP) and erythrocyte blood sedimentation rate (ESR). However up to date there is no laboratory marker for the pre-operative diagnosis of appendiceal perforation in acute appendicitis. Recently hyperbilirubinaemia has been associated with appendiceal perforation. Aim of this retrospective study is therefore to investigate if hyperbilirubinaemia has a diagnostic value for the pre-operative diagnosis of appendiceal perforation in patients with appendicitis.

Condition
Perforated Appendicitis

MedlinePlus related topics: Appendicitis Jaundice

U.S. FDA Resources

Study Type:	Observational
Study Design:	Case-Only, Retrospective
Official Title:	A Retrospective Study Investigating the Diagnostic Value of Hyperbilirubinaemia as a Predictive Factor for Appendiceal Perforation in Acute Appendicitis

Further study details as provided by Ruhr University of Bochum:

Biospecimen Retention: None Retained

Biospecimen Description:

Enrollment:	538
Study Start Date:	May 2008
Study Completion Date:	May 2008
Primary Completion Date:	May 2008 (Final data collection date for primary outcome measure)

Detailed Description:

We identified 538 patients with histologically proved acute appendicitis who underwent laparoscopic or conventional appendicectomy between January, 2004 and December, 2007 in a surgical department of an academic teaching hospital. A retrospective multiple chart review of the medical records including laboratory values (bilirubin, CRP, white blood count) and histological results was conducted.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

Patients who are appendectomied and who received preoperative Liver function test (bilirubin, liver transaminases GOT and GPT)

Criteria

Inclusion Criteria:

Appendicitis and a preoperative laboratory workup with Leukocytes, C-reactive Protein, Bilirubin and liver transaminases GOT and GPT

Exclusion Criteria:

Alcoholism
A history of viral hepatitis
Gilbert's disease
Dubin Johnson syndrome
BRIC (benign recurrent intra-hepatic cholestasis) and other documented biliary
Hemolytic or liver diseases associated with hyperbilirubinaemia.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00677417

Sponsors and Collaborators

Ruhr University of Bochum

Investigators

Principal Investigator:	Benno Mann, PD Dr. med.	Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital of the Ruhr-University Bochum, Germany
Principal Investigator:	Michael Sand, Dr. med.	Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital of the Ruhr-University Bochum, Germany

More Information

Responsible Party:	Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital of the Ruhr-University Bochum, Germany ( Dr. med. Michael Sand )
Study ID Numbers:	001
Study First Received:	May 12, 2008
Last Updated:	August 4, 2008
ClinicalTrials.gov Identifier:	NCT00677417
Health Authority:	Germany: Ethics Commission

Study placed in the following topic categories:

Digestive System Diseases
Gastrointestinal Diseases
Hyperbilirubinemia

Appendicitis
Intestinal Diseases
Gastroenteritis

Additional relevant MeSH terms:

Pathologic Processes
Cecal Diseases

ClinicalTrials.gov processed this record on January 14, 2009