• Academic Research Consortium (ARC) defined stent thrombosis [ Time Frame: Annually through to 5 years ] [ Designated as safety issue: Yes ]
  
• Composite rate of cardiac death and any myocardial infarction (MI) [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]
  

• Stent thrombosis [ Time Frame: at 24 hours and 30 days ] [ Designated as safety issue: Yes ]
  
• Composite rate of all death, any MI and any repeat revascularization (percutaneous coronary intervention [PCI] and coronary artery bypass graft [CABG]) [ Time Frame: at 30, 180 days and at 1, 2, 3, 4 and 5 years ] [ Designated as safety issue: Yes ]
  
• Composite rate of cardiac death, any MI attributed to the target vessel, and target lesion revascularization (TLR) [ Time Frame: at 30, 180 days and at 1, 2, 3, 4 and 5 years ] [ Designated as safety issue: Yes ]
  
• Death (cardiac death, vascular death, non-cardiovascular death) [ Time Frame: at 30, 180, days and at 1, 2, 3, 4 and 5 years ] [ Designated as safety issue: Yes ]
  
• MI (both Q-wave and non Q-wave) [ Time Frame: at 30, 180 days and at 1, 2, 3, 4 and 5 years ] [ Designated as safety issue: Yes ]
  
• Revascularization: TLR, TVR and non-TVR.(both PCI and CABG) [ Time Frame: at 30, 180 days and at 1, 2, 3, 4 and 5 years ] [ Designated as safety issue: Yes ]
  
• Compliance and therapy interruptions with prescribed adjunctive antiplatelet therapy [ Time Frame: at 14, 30, 180 days and at 1, 2, 3, 4 and 5 years ] [ Designated as safety issue: Yes ]
  
• Major bleeding complications [ Time Frame: at 14, 30, 180 days and at 1, 2, 3, 4 and 5 years ] [ Designated as safety issue: Yes ]
  
• Clinical device and procedural success [ Time Frame: Acute ] [ Designated as safety issue: No ]
  
• Patient health status (symptoms, physical function, and quality of life) as assessed by the Seattle Angina Questionnaire [ Time Frame: at baseline, 180 days, and 1 year ] [ Designated as safety issue: No ]
  
• Composite rate of cardiac death and any MI [ Time Frame: 30, 180 days and 2, 3, 4, 5 years ] [ Designated as safety issue: Yes ]
  
• Composite rate of all death and any MI [ Time Frame: 30, 180 days and 1, 2, 3, 4, 5 years. ] [ Designated as safety issue: Yes ]
  

Long term surveillance studies using a drug eluting stent (DES) may help elucidate mechanisms responsible for death, myocardial infarction, and late stent thrombosis risks not observed during controlled pre-market trials. This study will evaluate XIENCE™ V Everolimus Eluting Coronary Stent System (EECSS) performance in the "real world" when used by a broad group of physicians at a variety of health care facilities. Consequently, this protocol will include all consecutively enrolled patients in the United States of America (USA) who consent to participate and receive the XIENCE V EECSS, which is expected to represent the range of clinical use during commercialization.

Adjunctive anti-platelet therapy is a critical factor in optimizing long term DES safety.2,3 Despite established guidelines that recommend 6-12 months dual antiplatelet therapy, patients with DES implants frequently stop taking their medication early. Consequently, XIENCE V EECSS USA Post-Approval Study (XIENCE V USA) follow-up will document patient adherence and persistence with adjunctive antiplatelet drug therapy at several time points throughout the study.