National Toxicology Program

CASRN: 108-10-1

Formula: C6-H12-O

Synonyms/Common Names:

• HEXONE
• ISOPROPYLACETONE
• 4-METHYL-2-OXOPENTANE
• 4-METHYL-2-PENTANONE
• MIBK

Known Uses:

MIBK IS PRODUCED AT APPROX 200 MILLION LBS/YR AND IS USED AS A CHEMICAL INTERMED; AS A SOLVENT FOR PAINTS, VARNISHES AND NITROCELLULOSE; IN DRY CLEANING PREPARATIONS; AND AS A SYNTHETIC FLAVOR ADJUVANT. MIBK ALSO HAS A HIGH ENVIRONMENTAL RELEASE (27.7 MILLION LBS.YR, WITH >98% GOING INTO THE AIR) AND IS LISTED AS A HAZARDOUS AIR POLLUTANT UNDER THE 1990 AMENDS TO THE CLEAN AIR ACT. (EXEC SUM '95)

Long-Term Carcinogenicity

• 2-YEAR (Inhalation)  (C97006) Report Complete 
  • TR-538 (NTIS No. PB2007-107706)  (Peer Review 09/27/2005)
    Toxicology and Carcinogenesis Studies of Methyl Isobutyl Ketone (CAS No. 108-10-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Some Evidence 
  • Female Rats Equivocal Evidence 
  • Male Mice Some Evidence 
  • Female Mice Some Evidence 
  • Dose: R&M: 0, 450, 900, OR 1800 PPM

Genetic Toxicology

• Salmonella  (661200) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
  •  Negative