Testing Information

Testing Status of Agents at NTP

Water disinfection byproducts (Bromochloroacetic acid)

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http://ntp.niehs.nih.gov/go/TS-M980085

CASRN: 5589-96-8

Formula: C2 H2 BR CL O2

Synonyms/Common Names:

  • BROMOCHLOROACETIC ACID (WATER DISINFECTION BYPRODUCTS)

Known Uses:

EPA WATER CHEMICAL; BYPRODUCT OF WATER CHLORINATION

Short-Term Toxicity

  • 2-WEEK (Dosed-Water)  (C96019) Completed 
    •   (Peer Review 02/27/2008) Citation: Toxicology and Carcinogenesis Studies of Bromochloroacetic acid (CAS No. 5589-96-8) in F344/N Rats and B6C3F1 Mice (Drinking water studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 62.5, 125, 250, 500, OR 1000 MG/L; 10 SEX/SPECIES
  • 13-WEEK (Dosed-Water)  (C96019) Completed 
    •   (Peer Review 02/27/2008) Citation: Toxicology and Carcinogenesis Studies of Bromochloroacetic acid (CAS No. 5589-96-8) in F344/N Rats and B6C3F1 Mice (Drinking water studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 62.5, 125, 250, 500, OR 1000 MG/L; 20/SEX/SPECIES

Long-Term Carcinogenicity

  • 2-YEAR (Dosed-Water)  (C96019) Report Draft 
    • TR-549   (Peer Review 02/27/2008)
      Toxicology and Carcinogenesis Studies of Bromochloroacetic acid (CAS No. 5589-96-8) in F344/N Rats and B6C3F1 Mice (Drinking water studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R&M: 0, 250, 500, OR 1000 MG/L; 50/SEX/SPECIES/DOSE

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Web page last updated on January 22, 2009