Testing Information

Testing Status of Agents at NTP

Water disinfection byproducts (Dibromoacetonitrile)

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http://ntp.niehs.nih.gov/go/TS-M970038

CASRN: 3252-43-5

Formula: C2-H-BR2-N

Synonyms/Common Names:

  • DIBROMOACETONITRILE (WATER DISINFECTION BYPRODUCTS)

Known Uses:

INTERMEDIATE IN ORGANIC SYNTHESIS

Short-Term Toxicity

  • 2-WEEK (Dosed-Water)  (C96015) Completed 
    •   (Peer Review 02/27/2008) Citation: Toxicology and Carcinogenesis Studies of Dibromoacetonitrile (CAS No. 3252-43-5) in F344/N Rats and B6C3F1 Mice (Drinking Water studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 12.5, 25, 50, 100, OR 200 MG/L; 5/SEX/SPECIES
  • 13-WEEK (Dosed-Water)  (C96015) Completed 
    •   (Peer Review 02/27/2008) Citation: Toxicology and Carcinogenesis Studies of Dibromoacetonitrile (CAS No. 3252-43-5) in F344/N Rats and B6C3F1 Mice (Drinking Water studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 12.5, 25, 50, 100, OR 200 MG/L; 20 SEX/SPECIES

Long-Term Carcinogenicity

  • 2-YEAR (Dosed-Water)  (C96015) Report Draft 
    • TR-544   (Peer Review 02/27/2008)
      Toxicology and Carcinogenesis Studies of Dibromoacetonitrile (CAS No. 3252-43-5) in F344/N Rats and B6C3F1 Mice (Drinking Water studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Some Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R&M: 0, 50 100, OR 200 MG/L; 50 SEX/SPECIES/DOSE

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Web page last updated on January 22, 2009