Testing Information

Testing Status of Agents at NTP

Chromium picolinate monohydrate

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http://ntp.niehs.nih.gov/go/TS-M010098

CASRN: 27882-76-4

Related: 14639-25-9

Known Uses:

USED AS A DIETARY SUPPLEMENT FOR LOSING WEIGHT

Short-Term Toxicity

  • 13-WEEK (Dosed-Feed)  (C99027) Completed 
    •   (Peer Review 02/27/2008) Citation: Toxicology and Carcinogenesis Studies of Chromium Picolinate Monohydrate (CAS No. 27882-76-4) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 80, 240, 2000, 10000, OR 50000 PPM; 10/SEX/SPECIES

Long-Term Carcinogenicity

  • 2-YEAR (Dosed-Feed)  (C99027) Report Draft 
    • TR-556   (Peer Review 02/27/2008)
      Toxicology and Carcinogenesis Studies of Chromium Picolinate Monohydrate (CAS No. 27882-76-4) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R&M: 0, 2000, 10000, OR 50000 PPM; 50/SEX/SPECIES/DOSE

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intraperitoneal Injection; Intravenous)  (S0818) Completed 
    • Citation: [14C] CHROMIUM PICOLINATE MONOHYDRATE: DISPOSITION AND METABOLISM IN RATS AND MICE.
    • M Rats: F344/N; M Rats: F344/N; M Rats: F344/N
    • Dose: 0.2 mg/kg, 15 mg/kg

Genetic Toxicology

  • Micronucleus  (A39797) Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Equivocal 
  • Salmonella  (A36230) Completed 
    •  Negative 

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Web page last updated on January 22, 2009