National Toxicology Program

CASRN: 98-82-8

Related: CUMENE HYDROPEROXIDE (80-15-9)

Formula: C6 H5 CH(CH3)2

Synonyms/Common Names:

• ISOPROPYLBENZENE

Known Uses:

USED IN THE PRODUCTION OF PHENOL, ACETONE, AND ALPHA-METHYLSTYRENE; SOLVENT

Nomination Background

Short-Term Toxicity

• 2-WEEK (Inhalation)  (C96011) Completed 
  •   (Peer Review 05/16/2007) Citation: Toxicology and Carcinogenesis Studies of Cumene (CAS No. 98-82-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 250, 500, 1000, 2000, OR 4000 PPM; 5/SEX/SPECIES
• 13-WEEK (Inhalation)  (C96011) Completed 
  •   (Peer Review 05/16/2007) Citation: Toxicology and Carcinogenesis Studies of Cumene (CAS No. 98-82-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 62.5, 125, 250, 500, OR 1000 (20/SEX) M: 0, 62.5, 125, 250, 500, OR 1000 (10/SEX)

Long-Term Carcinogenicity

• 2-YEAR (Inhalation)  (C96011) Report Draft 
  • TR-542   (Peer Review 05/16/2007)
    Toxicology and Carcinogenesis Studies of Cumene (CAS No. 98-82-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Clear Evidence 
  • Female Rats Some Evidence 
  • Male Mice Clear Evidence 
  • Female Mice Clear Evidence 
  • Dose: R: 0, 250, 500, OR 1000 PPM MM: 0, 250, 500, OR 1000 PPM FM: 0, 125, 250, OR 500 PPM 50/SEX/SPECIES

Special Studies

• Absorption Disposition Metabolism Elimination (Gavage)  (S0972) On Test 
  • M/F Mice: B6C3F1; M Rats: F344/N
  • Dose: 10-1000 mg/kg

Genetic Toxicology

• Micronucleus  (A60520) Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Micronucleus  (A98265) Completed 
  • Rats: F344
  • Male Positive 
• Salmonella  (A42965) Completed 
  •  Negative