National Toxicology Program

CASRN: 1319-77-3

Formula: C7-H8-O

Synonyms/Common Names:

• CRESOLS (MIXED ISOMERS OF ORTHO, META, PARA)
• CRYSLOL
• HYDROXYTOLUENE
• METHYLPHENOL (9CI)
• TRICRESOL

Known Uses:

HOUSEHOLD DISINFECTANT, PAINTBRUSH CLEANER, IN LUBRICATING OILS, FUMIGANT, PHOTOGRAPHIC DEVELOPERS, EXPLOSIVES, ORGANIC INTERMEDIATE IN PROD'N OF COUMARIN, SALICYLALDEHYDE, SYNTHETIC RESINS, DEGREASING COMPOUNDS, OBTAINED FROM COAL TAR (HSDB 1990)

Short-Term Toxicity

• 4-WEEK (Dosed-Feed)  (C62260) Completed 
  • TOX-09 (NTIS No. PB92-174242)  (Peer Review 11/20/1990)
    Toxicity Studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-WEEK (Dosed-Feed)  (C62260) Report Complete 
  • TOX-09 (NTIS No. PB92-174242)  (Peer Review 11/20/1990)
    Toxicity Studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M:0,.03,.1,.3,1.0,3.0% IN DIET

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C62260B) Report Draft 
  • TR-550   (Peer Review 05/17/2007)
    Toxicology and Carcinogenesis Studies of Cresols (CAS No. 1319-77-3) in Male F344/N Rats and Female B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Equivocal Evidence 
  • Female Mice Some Evidence 
  • Dose: R: 0, 1500, 5000, OR 15,000 PPM AND M: 0, 1000, 3000, OR 10,000 PPM; 50/SPECIES/DOSE

Genetic Toxicology

• Micronucleus  (A73499) Completed 
  • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (990849) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
  •  Negative 
• Salmonella  (A67379) Completed 
  •  Negative 

Organ Systems Toxicity

• 27 WEEKS Continuous Breeding (Dosed-Feed)  (RACB90003) Completed 
  • NTIS No. PB92-191741
    Citation: Final Report on the Reproductive Toxicity of Meta-/Para-Cresol (MCPRE) in CD-1 Swiss Mice
  • Mice: Swiss
  • Dose: 0,0.25,0.5,1.0,2.0,3.0%; 0, 0.25,1.0,1.5%; 0,1.5%; 0,0.25,1.0,1.5%