Study Results & Research Projects

Summaries & Associations of Study Results

Levels from TR-552 Propargyl Alcohol (CAS No. 107-19-7)

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Target Organs and Levels of Evidence for:

TR-552 Toxicology and Carcinogenesis Studies of Propargyl Alcohol (CAS No. 107-19-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (CAS Number)Peer Review Date Primary UsesRoute/Exposure LevelsStudy Laboratory
Propargyl alcohol
107-19-7		05/17/2007STARTING MATERIAL/CHEM INTERMEDIATE (PHARM, ELECT & AGRI CHEMS.) STABILIZER (SOLVENTS IN PAINT PRODUCTS & STABILIZER USED IN ELECTROLESS PLATING BATHS.) CORROSION INHIBITOR (COMPONENT OF SOLDER FLUXES, SCALE-REMOVING PICKLING AGENTS & IN PETROLEUM WELLS.) MONOMER/POLYMER STARTING MATERIALS ( POLYDIACETYLENE-POLYESTERS, POLYSILOXANE RUBBERS & SEALANTS; MONOMER FOR SYN FIBERS & ADHESIVES & RESINS)Inhalation
R: 0, 16, 32, OR 64 PPM M: 0, 8, 16, OR 32 PPM; 50/SEX/SPECIES		Battelle Northwest Laboratory
Levels of Evidence
Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: adenoma, respiratory epithelium (0/49, 0/49, 0/50, 3/49)
    • Non-Neoplastic Lesions
  • Nasal Cavity: hyperplasia, respiratory epithelium; hyperplasia, glands, respiratory epithelium; hyperplasia, basal cell, olfactory epithelium; hyperplasia, olfactory epithelium; hyperplasia, glands, olfactory epithelium; atrophy, olfactory epithelium; metaplasia, respiratory, olfactory epithelium; degeneration, olfactory epithelium; necrosis, olfactory epithelium; hyaline droplet accumulation, olfactory epithelium; inflammation, chronic active
    • Other Considerations
  • Mononuclear cell leukemia: 21/49, 26/50, 23/50, 37/50
    • Female Rats: No Evidence
    TypeOrgan/Tissue (Lesion)
    Non-Neoplastic Lesions
  • Nasal Cavity: hyperplasia, respiratory epithelium; hyperplasia, glands, respiratory epithelium; hyperplasia, basal cell, olfactory epithelium; hyperplasia, glands, olfactory epithelium; atrophy, olfactory epithelium; metaplasia, respiratory, olfactory epithelium; necrosis, olfactory epithelium; hyaline droplet accumulation, olfactory epithelium, inflammation, chronic active
    • Male Mice: Some Evidence
    TypeOrgan/Tissue (Lesion)
    Neoplastic Lesions
  • Nasal Cavity: adenoma, respiratory epithelium (0/49, 1/50, 4/50, 7/50)
    		•
    May Have Been Related
  • Harderian Gland: adenoma 3/50, 10/50, 6/50, 11/50
    • Non-Neoplastic Lesions
  • Nasal Cavity: hyperplasia, respiratory epithelium; hyperplasia, glands, respiratory epithelium; metaplasia, squamous, respiratory epithelium; inflammation, suppurative; atrophy, turbinate; atrophy, olfactory epithelium; metaplasia, respiratory, olfactory epithelium
    • Female Mice: Some Evidence
    <
    TypeOrgan/Tissue (Lesion)
    Neoplastic Lesions
  • Nasal Cavity: adenoma, respiratory epithelium (0/50, 2/50, 4/50, 6/50)
    • Non-Neoplastic Lesions
  • Nasal Cavity: hyperplasia, respiratory epithelium; hyperplasia, glands, respiratory epithelium; metaplasia, squamous, respiratory epithelium; inflammation, suppurative; atrophy, turbinate; atrophy, olfactory epithelium; metaplasia, respiratory, olfactory epithelium


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    Web page last updated on January 28, 2008