Study Results & Research Projects

Summaries & Associations of Study Results

Levels from TR-546 Sodium Dichromate Dihydrate (CAS No. 7789-12-0)

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Target Organs and Levels of Evidence for:

TR-546 Toxicology and Carcinogenesis Studies of Sodium Dichromate Dihydrate (CAS No. 7789-12-0) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)

Chemical (CAS Number)Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Sodium dichromate dihydrate (VI)
7789-12-0		05/16/2007INTERMEDIATE; INDUSTRIAL CHEMICALDosed-Water
M/F RATS AND FM: 0, 14.3, 57.3, 172, OR 516 MG/L; MM: 0, 14.3, 28.6, 85.7, OR 258 MG/L		Southern Research Institute
Levels of Evidence
Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Oral Cavity: squamous cell carcinoma (0/50, 0/50, 0/49, 0/50, 6/49); squamous cell papilloma or carcinoma (0/50, 1/50, 0/49, 0/50, 7/49)
    • Non-Neoplastic Lesions
  • Lymph Node, Mesenteric: infiltration cellular, histiocyte
  • Liver: infiltration cellular, histiocyte
  • Intestines, Duodenum: infiltration cellular, histiocyte
    • Female Rats: Clear Evidence
    TypeOrgan/Tissue (Lesion)
    Neoplastic Lesions
  • Oral Cavity: squamous cell carcinoma (0/50, 0/50, 0/50, 2/50, 11/50); squamous cell papilloma, or carcinoma (1/50, 1/50, 0/50, 2/50, 11/50)
    • Non-Neoplastic Lesions
  • Lymph Node, Pancreatic: infiltration cellular, histiocyte
  • Lymph Node, Mesenteric: infiltration cellular, histiocyte
  • Intestines, Duodenum: infiltration cellular, histiocyte
  • Liver: infiltration cellular, histiocyte
    • Male Mice: Clear Evidence
    TypeOrgan/Tissue (Lesion)
    Neoplastic Lesions
  • Intestines: Duodenum: adenoma (1/50, 0/50, 1/50, 5/50, 15/50); Duodenum, Jejunum, or Ileum: adenoma (1/50, 1/50, 1/50, 5/50, 17/50), carcinoma (0/50, 2/50, 1/50, 3/50, 5/50), adenoma or carcinoma (1/50, 3/50, 2/50, 7/50, 20/50)
    • Non-Neoplastic Lesions
  • Lymph Node, Pancreatic: infiltration cellular, histiocyte
  • Lymph Node, Mesenteric: infiltration cellular, histiocyte
  • Intestines, Duodenum: epithelium, hyperplasia, diffuse; infiltration cellular, histiocyte
    • Female Mice: Clear Evidence
    TypeOrgan/Tissue (Lesion)
    Neoplastic Lesions
  • Intestines: Duodenum: adenoma (0/50, 0/50, 2/50, 13/50, 12/50); carcinoma (0/50, 0/50, 0/50, 1/50, 6/50); Jejunum: adenoma (0/50, 1/50, 0/50, 2/50, 5/50); Duodenum, Jejunum, or Ileum: adenoma (0/50, 1/50, 2/50, 15/50, 16/50), carcinoma (1/50, 0/50, 2/50, 3/50, 7/50), adenoma or carcinoma (1/50, 1/50, 4/50, 17/50, 22/50)
    • Non-Neoplastic Lesions
  • Intestines, Jejunum: epithelium, hyperplasia, diffuse; infiltration cellular, histiocyte
  • Lymph Node, Pancreatic: infiltration cellular, histiocyte
  • Intestines, Duodenum: epithelium, hyperplasia, diffuse; infiltration cellular, histiocyte
  • Liver: infiltration cellular, histiocyte
  • Lymph Node, Mesenteric: infiltration cellular, histiocyte


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    Web page last updated on January 28, 2008