National Toxicology Program

CASRN: 75-12-7

Formula: C H3 N O

Synonyms/Common Names:

• CARBAMALDEHYDE
• METHANAMIDE

Known Uses:

SOLVENT, SOFTENER, INTERMEDIATE IN ORGANIC SYNTHESIS; WATER-SOLUBLE INK FORMULATIONS.

Nomination Background

Short-Term Toxicity

• 2-WEEK (Gavage)  (C88123) Completed 
  •   (Peer Review 05/16/2007) Citation: Toxicology and Carcinogenesis Studies of Formamide (CAS No. 75-12-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 160, 312, 625, 1250 OR 2500 MG/KG; 5/SEX/SPECIES/DOSE
• 13-WEEK (Gavage)  (C88123) Subchronic Toxicology Review 
  •   (Peer Review 05/16/2007) Citation: Toxicology and Carcinogenesis Studies of Formamide (CAS No. 75-12-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 10, 20, 40, 80, OR 160 MG/KG; 10/SEX/SPECIES/DOSE

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C88123B) Report Draft 
  • TR-541   (Peer Review 05/16/2007)
    Toxicology and Carcinogenesis Studies of Formamide (CAS No. 75-12-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice Clear Evidence 
  • Female Mice Equivocal Evidence 
  • Dose: R&M: 0, 20, 40, OR 80 MG/KG; 50/SEX/DOSE

Special Studies

• Absorption Disposition Metabolism Elimination (Inhalation)  (S0533) Completed 
  • M Rats: F344/N
  • Dose: 10 mg/kg
• Metabolism (in-vitro)  (S0540) Completed 
  • Citation: ESTRAGOLE
  • M/F Rats: F344/N; M/F Mice: B6C3F1; M Human
  • Dose: NA
• Toxicokinetic Study (Intravenous; Gavage)  (S0613) Completed 
  • Citation: PART OF TWO YEAR TECHNICAL REPORT C88123
  • Rats; Mice; Rats; Mice
  • Dose: rats-IV: 10,30,90 mg/kg mice-IV: 20,60,100 mg/kg rats-gav: 36,300,600 mg/kg mice-gav:120,1000,2000 mg/kg

Genetic Toxicology

• Drosophila  (462104) Completed 
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Drosophila  (763972) Completed 
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Micronucleus  (A14799) Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (096297) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative 
• Salmonella  (799767) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative 
• Salmonella  (A95988) Completed 
  •  Negative 

Organ Systems Toxicity

• Continuous Breeding (Dosed-Water)  (RACB90005) Completed 
  • NTIS No. PB93-109213
    Citation: Final Report on the Reproductive Toxicity of Formamide in CD-1 Swiss Mice
  • Mice: Swiss
  • Dose: 0,250,500,1000,2000,3000; 0,100,350,750 PPM; 0,100,350,750 PPM; 0,100,350,750 PPM
• GD 6-19 Conventional Teratology (Gavage)  (TER97002) Completed 
  • NTIS No. PB99-139701
    Citation: Final Report on the Developmental Toxicity of Formamide (CAS# 75-12-7) Administered by Gavage to Sprague-Dawley CD Rats on Gestational Days 6-19
  • F Rats: Sprague Dawley
  • Dose: 0, 50, 100, OR 200 MG/KG/DAY
• GD 6-29 Conventional Teratology (Gavage)  (TER98002) Completed 
  • NTIS No. PB2001-104060
    Citation: Developmental Toxicity Evaluation of Formamide (CAS No. 75-12-7) Administered by Gavage to New Zealand White Rabbits on Gestational Days 6 through 29.
  • Citation: TER98002
  • F Rabbit: New Zealand White
  • Dose: 0, 35, 70 OR 140 MG/KG/DAY
• GD 6 - 19 Teratology Pilot Studies (Gavage)  (TRP97008) Completed 
  • F Rats: Sprague Dawley
  • Dose: 0, 62, 125, 250, 500, OR 1000 MG/KG/DAY
• GD 6-29 Teratology Pilot Studies (Gavage)  (TRP98002) Completed 
  • F Rabbit: New Zealand White
  • Dose: 0, 10, 20, 40, 80, OR 120 MG/KG/DAY