Testing Information

Testing Status of Agents at NTP

Water disinfection byproducts (Bromodichloromethane)

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http://ntp.niehs.nih.gov/go/TS-M970019

CASRN: 75-27-4

Formula: C-H-BR-CL2

Synonyms/Common Names:

  • BROMODICHLOROMETHANE (WATER DISINFECTION BYPRODUCTS)

Known Uses:

SOLVENT. CHEMICAL INTERMEDIATE. FLAME RETARDANT. (TDB)

Short-Term Toxicity

  • 4-WEEK (Dosed-Water)  (C20103A) Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: MR & FM: 0, 350, OR 700 MG/L
  • 4-WEEK (Gavage)  (C20103B) Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: MR & FM: 0, 50, OR 100 MG/KG
  • 3-WEEK (Dosed-Water)  (C96018) Completed 
    • NTIS No. PB 2006-111415  (Peer Review 12/09/2004)
      Citation: Toxicology and Carcinogenesis Studies of Bromodichloromethane (CAS No. 75-27-4) in Male F344/N Rats and Female B6C3F1 Mice (Drinking Water Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 43.7, 87.5, 175, 350, OR 700 MG/L; 10/MALE RATS AND 10 FEMALE MICE/GROUP
  • 13-Week (Dosed-Water) 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-YEAR (Dosed-Water)  (C96018) Report Complete 
    • TR-532 (NTIS No. PB 2006-111415)  (Peer Review 12/09/2004)
      Toxicology and Carcinogenesis Studies of Bromodichloromethane (CAS No. 75-27-4) in Male F344/N Rats and Female B6C3F1 Mice (Drinking Water Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Mice No Evidence 
    • Dose: R&M: 0, 175, 350, OR 700 MG/L; 50/GROUP

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Web page last updated on January 22, 2009