National Toxicology Program

CASRN: EMF+DMBA

Related: MAGENTIC FIELDS; DMBA

Formula: N/A

Synonyms/Common Names:

• DMBA + EMF INIT PROM
• EMF + DMBA INIT PROM
• MAGNETIC FIELDS (EMF) + DIMETHYLBENZANTHRACENE INITIATION PROMOTION

Secondary:

• 57-97-6 - 7,12-Dimethylbenzanthracene
• ELECTROMAG - Magnetic fields (EMF)

Known Uses:

SPECIAL EXPOSURE STUDY TO EVALUATE THE POTENTIAL OF 50/60 HZ MAGNETIC FIELDS TO PROMOTE BREAST CANCER IN DMBA TREATED FEMALE SPRAGUE DAWLEY RATS.

Short-Term Toxicity

• 13&26-WK (Gavage, Whole Body Exposure)  (C89029D) Completed 
  • NTIS No. PB2000-101313  (Peer Review 03/11/1998)
    Citation: Studies of Magnetic Field Promotion (DMBA Initiation) in Sprague-Dawley Rats (Gavage/Whole-Body Exposure Studies)
  • Rats: Sprague Dawley; Rats: Sprague Dawley; Rats: Sprague Dawley
  • Dose: 13-WEEK STUDY (female rats only): 5 mg/rat DMBA @ 4 wkly intervals (total 20 mg DMBA) followed by 50 hz (1 gauss), 60 hz (1 gauss) or 50 hz (5 gauss)/18.5 hr/day. 26-WEEK STUDY (female rats only): 10 mg/rat DMBA followed by 50 hz (1 gauss), 60 hz (1 gauss), or 50 hz (5 gauss)/18.5 hr/day. Controls will receive vehicle (sesame oil) or DMBA with <1 milligauss. 100 per group.