National Toxicology Program

CASRN: 96-18-4

Related: 1,2,3-TRICHLOROPROPANE

Formula: C3 H5 CL3

Known Uses:

SPECIAL STUDY TO EVALUATE THE UTILITY OF THE SMALL FISH MODELS IN HAZARD CHARACTERIZATION AND HOW IT CAN BE RELATED TO RODENT STUDIES.

Short-Term Toxicity

• 1-WEEK (Aquat)  (C95008A) Completed 
  • NTIS No. PB 2006-102382  (Peer Review 02/18/2004)
    Citation: Carcinogenesis Studies of 2,2-bis(Bromomethyl)-1,3-Propanediol, Nitromethane, and 1,2,3-Trichloropropane (CAS Nos. 3296-90-0, 75-52-5, and 96-18-4) in Guppies (Poecilia reticulata) and Medaka (Oryzias latipes) (Waterborne Studies)
  • Fish: Medaka (Oryzias Latipes)
  • Dose: 0, 10.4, 17.4, 29, 48, OR 80 MG/L
• 1-WEEK (Aquat)  (C95008B) Completed 
  • NTIS No. PB 2006-102382  (Peer Review 02/18/2004)
    Citation: Carcinogenesis Studies of 2,2-bis(Bromomethyl)-1,3-Propanediol, Nitromethane, and 1,2,3-Trichloropropane (CAS Nos. 3296-90-0, 75-52-5, and 96-18-4) in Guppies (Poecilia reticulata) and Medaka (Oryzias latipes) (Waterborne Studies)
  • Fish: Guppy (Poecilia Reticulata)
  • Dose: 0, 10.4, 17.4, 29, 48, OR 80 MG/L
• 4-WEEK (Aquat)  (C95008A) Completed 
  • NTIS No. PB 2006-102382  (Peer Review 02/18/2004)
    Citation: Carcinogenesis Studies of 2,2-bis(Bromomethyl)-1,3-Propanediol, Nitromethane, and 1,2,3-Trichloropropane (CAS Nos. 3296-90-0, 75-52-5, and 96-18-4) in Guppies (Poecilia reticulata) and Medaka (Oryzias latipes) (Waterborne Studies)
  • Fish: Medaka (Oryzias Latipes)
  • Dose: 0, 6.5, 10.8, 18, 30, OR 50 MG/L
• 4-WEEK (Aquat)  (C95008B) Completed 
  • NTIS No. PB 2006-102382  (Peer Review 02/18/2004)
    Citation: Carcinogenesis Studies of 2,2-bis(Bromomethyl)-1,3-Propanediol, Nitromethane, and 1,2,3-Trichloropropane (CAS Nos. 3296-90-0, 75-52-5, and 96-18-4) in Guppies (Poecilia reticulata) and Medaka (Oryzias latipes) (Waterborne Studies)
  • Fish: Guppy (Poecilia Reticulata)
  • Dose: 0, 6.5, 10.8, 18, 30, OR 50 MG/L

Long-Term Carcinogenicity

• 13-MONTH (Aquat)  (C95008A) Report Complete 
  • TR-528 (NTIS No. PB 2006-102382)  (Peer Review 02/18/2004)
    Carcinogenesis Studies of 2,2-bis(Bromomethyl)-1,3-Propanediol, Nitromethane, and 1,2,3-Trichloropropane (CAS Nos. 3296-90-0, 75-52-5, and 96-18-4) in Guppies (Poecilia reticulata) and Medaka (Oryzias latipes) (Waterborne Studies)
  • Fish: Medaka (Oryzias Latipes)
  • Carcinogenesis Results
  • Male Fish Positive 
  • Female Fish Positive 
  • Dose: Medaka: 0, 4.5, 9, OR 18 MG/L (2 REPLICATES PER TREATMENT GROUP) 170 FISH/EACH REPLICATE AQUARIUM
• 16-MONTH (Aquat)  (C95008B) Report Complete 
  • TR-528 (NTIS No. PB 2006-102382)  (Peer Review 02/18/2004)
    Carcinogenesis Studies of 2,2-bis(Bromomethyl)-1,3-Propanediol, Nitromethane, and 1,2,3-Trichloropropane (CAS Nos. 3296-90-0, 75-52-5, and 96-18-4) in Guppies (Poecilia reticulata) and Medaka (Oryzias latipes) (Waterborne Studies)
  • Fish: Guppy (Poecilia Reticulata)
  • Carcinogenesis Results
  • Male Fish Positive 
  • Female Fish Positive 
  • Dose: Guppy: 0, 4.5, 9, OR 18 MG/L (2 REPLICATES PER TREATMENT GROUP) 170 FISH/EACH REPLICATE AQUARIUM