National Toxicology Program

CASRN: 3296-90-0

Related: 2,2-BIS(BROMOMETHYL)1,3-PROPANEDIOL

Known Uses:

SPECIAL STUDY TO EVALUATE THE UTILITY OF THE SMALL FISH MODELS IN HAZARD CHARACTERIZATION AND HOW IT CAN BE RELATED TO RODENT STUDIES.

Short-Term Toxicity

• 1-WEEK (Aquat)  (C94002A) Completed 
  • NTIS No. PB 2006-102382  (Peer Review 02/18/2004)
    Citation: Carcinogenesis Studies of 2,2-bis(Bromomethyl)-1,3-Propanediol, Nitromethane, and 1,2,3-Trichloropropane (CAS Nos. 3296-90-0, 75-52-5, and 96-18-4) in Guppies (Poecilia reticulata) and Medaka (Oryzias latipes) (Waterborne Studies)
  • Fish: Medaka (Oryzias Latipes)
  • Dose: 0, 32.4, 54, 90, 150, OR 250 MG/L; 10 FISH/DOSE/SPECIES (14-DAY-OLD FISH)
• 1-WEEK (Aquat)  (C94002B) Completed 
  • NTIS No. PB 2006-102382  (Peer Review 02/18/2004)
    Citation: Carcinogenesis Studies of 2,2-bis(Bromomethyl)-1,3-Propanediol, Nitromethane, and 1,2,3-Trichloropropane (CAS Nos. 3296-90-0, 75-52-5, and 96-18-4) in Guppies (Poecilia reticulata) and Medaka (Oryzias latipes) (Waterborne Studies)
  • Fish: Guppy (Poecilia Reticulata)
  • Dose: 0, 32.4, 54, 90, 150, OR 250 MG/L; 10 FISH/DOSE/SPECIES (14-DAY-OLD FISH)
• 4-WEEK (Aquat)  (C94002A) Completed 
  • NTIS No. PB 2006-102382  (Peer Review 02/18/2004)
    Citation: Carcinogenesis Studies of 2,2-bis(Bromomethyl)-1,3-Propanediol, Nitromethane, and 1,2,3-Trichloropropane (CAS Nos. 3296-90-0, 75-52-5, and 96-18-4) in Guppies (Poecilia reticulata) and Medaka (Oryzias latipes) (Waterborne Studies)
  • Fish: Medaka (Oryzias Latipes)
  • Dose: 0, 19.4, 32.4, 54, 90, OR 150 MG/L; 20 FISH/D0SE/SPECIES
• 4-WEEK (Aquat)  (C94002B) Completed 
  • NTIS No. PB 2006-102382  (Peer Review 02/18/2004)
    Citation: Carcinogenesis Studies of 2,2-bis(Bromomethyl)-1,3-Propanediol, Nitromethane, and 1,2,3-Trichloropropane (CAS Nos. 3296-90-0, 75-52-5, and 96-18-4) in Guppies (Poecilia reticulata) and Medaka (Oryzias latipes) (Waterborne Studies)
  • Fish: Guppy (Poecilia Reticulata)
  • Dose: 0, 19.4, 32.4, 54, 90, OR 150 MG/L; 20 FISH/DOSE/SPECIES

Long-Term Carcinogenicity

• 14-MONTH (Aquat)  (C94002A) Report Complete 
  • TR-528 (NTIS No. PB 2006-102382)  (Peer Review 02/18/2004)
    Carcinogenesis Studies of 2,2-bis(Bromomethyl)-1,3-Propanediol, Nitromethane, and 1,2,3-Trichloropropane (CAS Nos. 3296-90-0, 75-52-5, and 96-18-4) in Guppies (Poecilia reticulata) and Medaka (Oryzias latipes) (Waterborne Studies)
  • Fish: Medaka (Oryzias Latipes)
  • Carcinogenesis Results
  • Male Fish Positive 
  • Female Fish Negative 
  • Dose: Medaka: 0, 24, 60, 150 MG/L 160 FISH/DOSE/SPECIES
• 16-MONTH (Aquat)  (C94002B) Report Complete 
  • TR-528 (NTIS No. PB 2006-102382)  (Peer Review 02/18/2004)
    Carcinogenesis Studies of 2,2-bis(Bromomethyl)-1,3-Propanediol, Nitromethane, and 1,2,3-Trichloropropane (CAS Nos. 3296-90-0, 75-52-5, and 96-18-4) in Guppies (Poecilia reticulata) and Medaka (Oryzias latipes) (Waterborne Studies)
  • Fish: Guppy (Poecilia Reticulata)
  • Carcinogenesis Results
  • Male Fish Positive 
  • Female Fish Inconclusive 
  • Dose: Guppy: 160 FISH/DOSE/SPECIES