National Toxicology Program

CASRN: 822-36-6

Related: 693-98-1 (2-METHYLIMIDAZOLE)

Formula: C4-H6-N2

Synonyms/Common Names:

• 1H-IMIDAZOLE, 4-METHYL (9CI)
• 4-MEI

Known Uses:

HAS BEEN REPORTED AS ONE OF SEVERAL COMPOUNDS RESULTING FROM INTERACTION OF REDUCING SUGARS WITH AMMONIA; MAJOR PHARMACEUTICAL INTERMEDIATE; STARTING MATERIAL FOR DRUG USED FOR ULCER THERAPY & OTHER DRUGS, ANTISEPTIC AGENTS; PHOTO DEVEL SOLUN.

Nomination Background

Short-Term Toxicity

• 2-WEEK (Dosed-Feed)  (C92013) Completed 
  • TOX-67 (NTIS No. PB2004-105393)  (Peer Review 04/22/2003)   (Toxicity Peer Review 06/15/2002)
    Toxicity Studies of 2-Methylimidazole and 4-Methylimidazole Administered in Feed to F344/N Rats and B6C3F1Mice (CAS No. 693-98-1 and 822-36-6)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 18, 54, OR 161 MG/KG M: 0, 41, 125, OR 375 MG/KG (0, 300, 800, OR 2500 PPM IN FEED) 5/SEX/SPECIES/GROUP
• 13-WEEK (Dosed-Feed)  (C92013) Report Complete 
  • TOX-67 (NTIS No. PB2004-105393)  (Peer Review 04/22/2003)   (Toxicity Peer Review 06/15/2002)
    Toxicity Studies of 2-Methylimidazole and 4-Methylimidazole Administered in Feed to F344/N Rats and B6C3F1Mice (CAS No. 693-98-1 and 822-36-6)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 625, 1250, 2500, 5000, OR 10000 PPM IN FEED; 10/SEX/DOSE

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C92013B) Report Complete 
  • TR-535 (NTIS No. PB2007-106091)  (Peer Review 09/28/2005)
    Toxicology and Carcinogenesis Studies of 4-Methylimidazole (CAS No. 822-36-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats Equivocal Evidence 
  • Male Mice Clear Evidence 
  • Female Mice Clear Evidence 
  • Dose: MR: 0, 625, 1250, OR 2500 PPM; FR: 0, 1250, 2500, OR 5000 PPM; M: 0, 312, 625, OR 1250 PPM; 50/SEX/SPECIES/GROUP

Special Studies

• Toxicokinetic Study (Gavage; Intravenous)  (S0332) Completed 
  • Citation: YUAN, JH & BURKA, LT, TOXICOKINETICS OF 4-METHYLIMIDAZOLE IN THE MALE F344 RAT, XENOBIOTICA 25, 885-894, 1995.
  • M Rats: F344/N; M Rats: F344/N
  • Dose: 5, 50, 150 MG/KG ORAL; 5 MG/KG IV

Genetic Toxicology

• Micronucleus  (A12637) Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Micronucleus  (A38684) Completed 
  • Rats: F344
  • Male Negative 
• Micronucleus  (A49564) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (A41578) Completed 
  •  Negative 
• Salmonella  (A53668) Completed 
  •  Negative