National Toxicology Program

CASRN: URETHCOMB

Related: URETHANE (51-79-6) AND ETHYL ALCOHOL (64-17-5)

Formula: C3 H7 N O2 + C2 H6 O

Secondary:

• 64-17-5 - Ethanol
• 51-79-6 - Urethane

Known Uses:

(URETHANE) CHEMICAL INTERMEDIATE; SOLUBILIZER FOR COSMETICS AND PESTICIDES; (ETHANOL) SOLVENT; IN ALCOHOLIC BEVERAGES AND MANF. OF DENATURED ALCOHOLS; IN GASOHOL; ANTI-FREEZE AGENT; CHEMICAL INTERMEDIATE; IN SYNTHETIC RUBBER, PHARMACEUTICALS, DISINFECTANTS

Short-Term Toxicity

• 13-WEEK (Dosed-Water)  (C00602C) Report Complete 
  • TOX-52 (NTIS No. PB96-175575)  (Toxicity Peer Review 06/00/1995)
    Toxicity Studies of Urethane in Drinking Water and Urethane in 5% Ethanol in F344/N Rats and B6C3F1Mice (CAS No. 51-79-6)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M:(WITH 5% ETHANOLIN WATER)0.011, 0.033, 0.11, 0.33, OR 1.0 G/100 ML

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Water)  (C00602F) Report Complete 
  • TR-510 (NTIS No. PB2005-103486)  (Peer Review 09/05/2002)
    Toxicology and Carcinogenesis Studies of Urethane + Ethanol (CAS Nos. 51-79-6 & 64-17-5) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
  • Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
  • Dose: 0, 10, 30, OR 90 PPM

Genetic Toxicology

• Micronucleus  (A23852) Completed 
  • Mice: B6C3F1
  • Male Positive 
  • Female Positive