National Toxicology Program

CASRN: 116355-83-0

Formula: C34 H59 N O15

Synonyms/Common Names:

• 1,2,3-PROPANETRICARBOXYLIC ACID, 1,1'-(1-(12-AMINO-4,9,11-TRIHYDROXY-2-METHYLTRIDECYL)-2-(1-METHYLPENTYL)-1,2-ETHANEDIYL) ESTER (9CI)

Known Uses:

MYCOTOXIN PRODUCED BY CERTAIN STRAINS OF FUSARIUM MONILIFORME, A COMMONLY OCCURRING FUNGI ON U.S. AGRICULTURAL PRODUCTS, ESPECIALLY CORN. NO KNOWN USES

Nomination Background

Short-Term Toxicity

• 4-WEEK (Dosed-Feed)  (C92002B) Completed 
  • NTIS No. PB2002-103492  (Peer Review 05/21/1999)
    Citation: Toxicology and Carcinogenesis Studies of Fumonisin B1 (CAS No. 116355-83-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
  • Dose: R&M: 100, 175, 250, OR 500 PPM
• 13-WEEK (Dosed-Feed)  (C92002) Completed 
  • NTIS No. PB2002-103492
    Citation: Toxicology and Carcinogenesis Studies of Fumonisin B1 (CAS No. 116355-83-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 1, 3, 9, 27, OR 81 PPM; 15/SEX/SPECIES/GROUP

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C92002B) Report Complete 
  • TR-496 (NTIS No. PB2002-103492)  (Peer Review 05/21/1999)
    Toxicology and Carcinogenesis Studies of Fumonisin B1 (CAS No. 116355-83-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
  • Carcinogenesis Results
  • Male Rats Clear Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice Clear Evidence 
  • Dose: R&M: 0, 5, 15, 50, 100, OR 150 PPM

Special Studies

• C. elegans  (S0952) Completed 
  • Nematode: C. elegans

Genetic Toxicology

• Salmonella  (A44914) On Test 

Organ Systems Toxicity

• GD 3-19 Conventional Teratology (Gavage)  (TER94002) Completed 
  • F Rabbit: New Zealand White
  • Dose: 0.25, 0.50, 1.25, OR 1.75 MG/KG -- DOSE FINDING STUDY