National Toxicology Program

CASRN: 93-83-4

Related: 13961-86-9 (OLEIC ACID DIETHANOLAMINE)

Formula: C22 H43 N O3

Synonyms/Common Names:

• N,N-DI(2-HYDROXYETHYL)OLEAMIDE
• 9-OCTADECENAMIDE, N,N-BIS(2-HYDROXYETHYL)-, (Z)- (9CI)
• OLEAMIDE DEA
• OLEIC ACID DIETHANOLAMIDE

Known Uses:

SURFACTANT IN WAX EMULSION; TO INCREASE SHAMPOO VISCOSITY

Short-Term Toxicity

• 13-WEEK (Topical Application)  (C91014) Completed 
  • NTIS No. PB99-167561  (Peer Review 12/10/1997)
    Citation: Toxicology and Carcinogenesis Studies of Oleic Acid Diethanolamine Condensate (CAS No. 93-83-4) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 25, 50, 100, 200, OR 400 MG/KG; 20/SEX/GROUP M: 0, 50, 100, 200, 400, OR 800 MG/KG; 10/SEX/GROUP

Long-Term Carcinogenicity

• 2-YEAR (Topical Application)  (C91014) Report Complete 
  • TR-481 (NTIS No. PB99-167561)  (Peer Review 12/10/1997)
    Toxicology and Carcinogenesis Studies of Oleic Acid Diethanolamine Condensate (CAS No. 93-83-4) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R: 0, 50, OR 100 MG/KG; 50/SEX/GROUP M: 0, 15, OR 30 MG/KG; 55/SEX/GROUP

Genetic Toxicology

• Mouse Lymphoma  (932123) Completed 
  •  Negative 
• Micronucleus  (A72594) Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (669959) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Negative 

Organ Systems Toxicity

• Immunotoxicity (Topical Application)  (IMM90004) Completed 
  • NTIS No. PB92-140383
    Citation: Summary Reports on Immunotoxicology Vol. 1, No. 1-15
  • Citation: SUMMARY (1-15)
  • F Mice: B6C3F1
  • Mice Female Negative 
  • Dose: 0, 1, 3, 10%