Testing Status of Agents at NTP
Scopolamine hydrobromide trihydrate
CASRN: 6533-68-2
Related: SCOPOLAMINE HYDROBROMIDE (114-48-8)
Formula: C17 H21 N O4.BR-H.3H2-O
Synonyms/Common Names:
- BENZENEACETIC ACID, ALPHA-(HYDROXYMETNYL)-,9-METHYL-3-OXA-9-AZATRICYCLO(3.3.1.0(2,4))NON-7-YL ESTER, HYDROBROMIDE, TRIHYDRATE, (7(S)-(1ALPHA,2BETA,4BETA,5ALPHA,7BETA))- (9CI)
- HYOSCINE HYDROBROMIDE
Known Uses:
ANTICHOLINERGIC; TREATMENT OF MOTION SICKNESS
Short-Term Toxicity
- 14-Day (Gavage)
(C03098A) Completed
- NTIS No. PB97-208946
Citation: Toxicology and Carcinogenesis Studies of Scopolamine Hydrobromide Trihydrate (CAS No. 6533-68-2) in F344 Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB97-208946
- 14-Day (Dosed-Water)
(C03098B) Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Gavage)
(C03098A) Completed
- NTIS No. PB97-208946
Citation: Toxicology and Carcinogenesis Studies of Scopolamine Hydrobromide Trihydrate (CAS No. 6533-68-2) in F344 Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: 0,15,1200 MG/KG/10 PER GROUP
- NTIS No. PB97-208946
Long-Term Carcinogenicity
- 2&3-YEAR (Gavage)
(C03098C) Report Complete
- TR-445 (NTIS No. PB97-208946)
(Peer Review 06/20/1995)
Toxicology and Carcinogenesis Studies of Scopolamine Hydrobromide Trihydrate (CAS No. 6533-68-2) in F344 Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: R&M: 0,1,5, OR 25 MG/KG; 70/GROUP DIET RESTRICTION MICE: 0 OR 25 MG/KG;70/GROUP
- TR-445 (NTIS No. PB97-208946)
(Peer Review 06/20/1995)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(243331) Completed
- Chromosome Aberation Weakly Positive
- Sister Chromatid Exchange Negative
- Salmonella
(907250) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
- Negative
Web page last updated on January 22, 2009