National Toxicology Program

CASRN: 20265-96-7

Related: P-CHLOROANILINE (106-47-8)

Formula: C6-H6-NCL HCL

Synonyms/Common Names:

• 4-CHLOROBENZENAMINE HYDROCHLORIDE (9CI)

Known Uses:

AN AROMATIC AMINE WIDELY USED IN THE DYE, CHEMICAL, TEXTILE, RUBBER AND OTHER INDUSTRIES; AS AN INTERMEDIATE IN THE MANUFACTURE OF DYES AND PIGMENTS; DETECTED AS A DEGRADATION PRODUCT IN SOME PHARMACEUTICAL PREPARATIONS.

Short-Term Toxicity

• 14-Day (Gavage)  (C02039B) Completed 
  • NTIS No. PB90-222563  (Peer Review 04/18/1988)
    Citation: Toxicology and Carcinogenesis Studies of para-Chloroaniline Hydrochloride (CAS No. 20265-96-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C02039B) Completed 
  • NTIS No. PB90-222563  (Peer Review 04/18/1988)
    Citation: Toxicology and Carcinogenesis Studies of para-Chloroaniline Hydrochloride (CAS No. 20265-96-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,5,80, M: 0,7.5,120 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C02039B) Report Complete 
  • TR-351 (NTIS No. PB90-222563)  (Peer Review 04/18/1988)
    Toxicology and Carcinogenesis Studies of para-Chloroaniline Hydrochloride (CAS No. 20265-96-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Clear Evidence 
  • Female Rats Equivocal Evidence 
  • Male Mice Some Evidence 
  • Female Mice No Evidence 
  • Dose: R: 0,2,6,18, M: 0,3,10,30 MG/KG/50 PER GROUP

Genetic Toxicology

• Micronucleus  (A79778) Completed 
  • Mice: B6C3F1
  • Male Positive