National Toxicology Program

CASRN: 80-07-9

Formula: C12-H8-CL2-02-S

Synonyms/Common Names:

• 1,1'-SULFONYLBIS(4-CHLORO-BENZENE) (9CI)

Known Uses:

STARTING MATERIAL IN PROD'N OF PLASTICS

Nomination Background

Short-Term Toxicity

• 13-WEEK (Dosed-Feed)  (C88120) Completed 
  • NTIS No. PB2002-100580
    Citation: Toxicology and Carcinogenesis Studies ofp,p'-Dichlorodiphenyl Sulfone (CAS No. 80-07-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 30, 100, 300, 1000, & 3000 PPM; 10/GRP/SEX

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C88120B) Report Complete 
  • TR-501 (NTIS No. PB2002-100580)  (Peer Review 05/18/2000)
    Toxicology and Carcinogenesis Studies ofp,p'-Dichlorodiphenyl Sulfone (CAS No. 80-07-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: MR: 0, 10, 30, OR 100 PPM; FR & MICE: 0, 30, 100, OR 300 PPM; 50/SEX/DOSE

Special Studies

• Absorption Disposition Metabolism Elimination (Gavage)  (S0160) Completed 
  • Citation: ABSORPTION AND DISPOSITION OF [14C]P,P'-DICHLORODIPHENYL SULFONE (DDS) ADMINISTERED TO F-344 RATS
  • M Rats: F344/N
  • Dose: 10, 100, 1000 MG/KG
• Absorption Disposition Metabolism Elimination  (S0595) Completed 
  • Citation: MATHEWS, J.M., BLACK, S.L., MATTHEWS, H.B.: P,P'-DICHLORODIPHENYL SULPHONE METABOLISM AND DISPOSITION IN RATS. DRUG MET. AND DISP., V24:NO.5:P579-587, 1996.
  • M Rats: F344/N
  • Dose: IV:10 mg/kg
• Toxicokinetic Study (Intravenous)  (S0631) Completed 
  • Citation: PRELIMINARY ONLY, NO FULL TKS DONE
  • M Rats: F344/N
  • Dose: 1.0 mg/kg

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (133717) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Inconclusive 
• Micronucleus  (A64289) Completed 
  • Mice: B6C3F1
  • Male Positive 
• Salmonella  (147825) Completed 
  •  Negative