National Toxicology Program

CASRN: 25265-71-8

Formula: C6-H14-03

Synonyms/Common Names:

• OXYBISPROPANOL - (9CI)

Known Uses:

INTERMEDIATE FOR POLYESTER RESINS, SOLVENT EXTRACTION OF AROMATIC HYDROCARBONS, STEAM SET PRINTING INKS, STABILIZER IN COSMETICS

Nomination Background

Short-Term Toxicity

• 2-WEEK (Dosed-Water)  (C88031) Completed 
  • NTIS No. PB2005100832
    Citation: Toxicology and Carcinogenesis Studies of Dipropylene Glycol (CAS No. 25265-71-8) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 0.5, 1.0, 2.0, 4.0, OR 8.0 % (5/S/S)
• 13-WEEK (Dosed-Water)  (C88031) Completed 
  • NTIS No. PB2005100832
    Citation: Toxicology and Carcinogenesis Studies of Dipropylene Glycol (CAS No. 25265-71-8) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 0.5, 1.0, 2.0, 4.0 OR 8.0 % (10/S/S)

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Water)  (C88031B) Report Complete 
  • TR-511 (NTIS No. PB2005100832)  (Peer Review 09/05/2002)
    Toxicology and Carcinogenesis Studies of Dipropylene Glycol (CAS No. 25265-71-8) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R: 0, 0.25, 1.0, OR 4.0% M: 0, 1.0, 2.0, OR 4.0%; 50/SEX/DOSE

Genetic Toxicology

• Micronucleus  (A31713) Completed 
  • Mice
  • Male Not Tested 
• Salmonella  (850639) Completed 
  •  Negative 

Organ Systems Toxicity

• GD 6-19 Conventional Teratology (Gavage)  (TER90014) Completed 
  • NTIS No. PB92-238294/AS
    Citation: Final Report on the Developmental Toxicity of Dipropylene Glycol in New Zealand White Rabbits
  • Rabbit: New Zealand White
  • Rabbits Maternal Negative 
  • Rabbits Fetal Negative 
  • Dose: 0,200,400,800,1200 MG/KG/DAY
• GD 6-15 Conventional Teratology (Gavage)  (TER91013) Completed 
  • NTIS No. PB92-196179
    Citation: Final Report on the Developmental Toxicity of Dipropylene Glycol in Sprague-Dawley (CD) Rats
  • Rats: Sprague Dawley
  • Rats Maternal Positive 
  • Rats Fetal Positive 
  • Dose: 0,800,2000,5000 MG/KG/DAY
• GD 6 THROUGH 15 Teratology Pilot Studies (Gavage)  (TRP90005) Completed 
  • F Rats: Sprague Dawley
  • Dose: 0, 800, 1500, 3000, 5000, OR 8000 MG/KG
• GD 6 THROUGH 19 Teratology Pilot Studies (Gavage)  (TRP90006) Completed 
  • F Rabbit: New Zealand White
  • Dose: 0, 200, 800, 1500, 3000, OR 5000 MG/KG