Testing Information

Testing Status of Agents at NTP

Isobutene

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http://ntp.niehs.nih.gov/go/TS-M88113

CASRN: 115-11-7

Formula: C4-H8

Synonyms/Common Names:

  • 2-METHYL-1-PROPENE

Known Uses:

PROD'N OF DIISOBUTYLENE, TRIMERS, BUTYL RUBBER, ANTIOXIDANTS FOR FOODS, PACKAGING, FOOD SUPPLEMENTS & PLASTICS, ISOOCTANE, HIGH-OCTANE AVIATION GASOLINE. POLYISOBUTENE RESINS. (NTP EXECUTIVE SUMMARY)

Short-Term Toxicity

  • 2-WEEK (Inhalation)  (C88070) Completed 
    • NTIS No. PB99-147670  (Peer Review 12/10/1997)
      Citation: Toxicology and Carcinogenesis Studies of Isobutene (CAS No. 115-11-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 4-DAY EXPOSURE, MAINTAIN ANIMALS FOR 1 WEEK FOLLOWING EXPOSURE. 0, 500, 1000, 2000, 4000, OR 8000 PPM (10/SEX/SPECIES/GROUP) 11 DAYS
  • 13-WEEK (Inhalation)  (C88070) Completed 
    • NTIS No. PB99-147670  (Peer Review 12/10/1997)
      Citation: Toxicology and Carcinogenesis Studies of Isobutene (CAS No. 115-11-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 500, 1000, 2000, 4000, OR 8000 PPM (10/SEX/SPECIES/GROUP)

Long-Term Carcinogenicity

  • 2-YEAR (Inhalation)  (C88070) Report Complete 
    • TR-487 (NTIS No. PB99-147670)  (Peer Review 12/10/1997)
      Toxicology and Carcinogenesis Studies of Isobutene (CAS No. 115-11-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R&M: 0, 500, 2000, OR 8000 PPM (50/SEX/SPECIES/GROUP)

Special Studies

  • Absorption Disposition Metabolism Elimination (Inhalation)  (S0137) Completed 
    • Citation: TOX. AND APPL. PHARM VOL 123:50-61 (1993) DISPOSITION OF INHALED ISOBUTENE IN F344/N RATS, HENDERSON, R.F., SABOURIN P.J., BECHTOLD, W.E, STEINBERG, B, AND CHANG I-Y.
    • M Rats: F344/N
    • Dose: 4, 40, 400 PPM

Genetic Toxicology

  • Micronucleus  (A91962) Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (295184) Completed 
    •  Negative 

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Web page last updated on January 22, 2009