Testing Information

Testing Status of Agents at NTP

Malonaldehyde, sodium salt

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http://ntp.niehs.nih.gov/go/TS-M20326

CASRN: 24382-04-5

Related: MALONALDEHYDE 542-78-9

Formula: C3-H3-O2.NA

Synonyms/Common Names:

  • PROPANEDIAL, ION(1-), SODIUM (9CI)

Known Uses:

INDICATOR OF FOOD FRESHNESS; NO COMMERCIAL USE

Short-Term Toxicity

  • 14-Day (Gavage)  (C54842) Completed 
    • NTIS No. PB89-204010  (Peer Review 03/04/1987)
      Citation: Toxicology and Carcinogenesis Studies of Malonaldehyde, Sodium Salt (3-Hydroxy-2-propenal, Sodium Salt) (CAS No. 24382-04-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C54842) Completed 
    • NTIS No. PB89-204010  (Peer Review 03/04/1987)
      Citation: Toxicology and Carcinogenesis Studies of Malonaldehyde, Sodium Salt (3-Hydroxy-2-propenal, Sodium Salt) (CAS No. 24382-04-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,43,714 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Gavage)  (C54842) Report Complete 
    • TR-331 (NTIS No. PB89-204010)  (Peer Review 03/04/1987)
      Toxicology and Carcinogenesis Studies of Malonaldehyde, Sodium Salt (3-Hydroxy-2-propenal, Sodium Salt) (CAS No. 24382-04-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0,50,100, M: 0,60,120 MG/KG/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (011163) Completed 
    • Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Positive 
  • Drosophila  (016951) Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Inconclusive 
  • Mouse Lymphoma  (398708) Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    •  Positive 
  • Salmonella  (151212) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

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Web page last updated on January 22, 2009