National Toxicology Program

CASRN: 126-98-7

Formula: C4 H5 N

Synonyms/Common Names:

• MAN
• 2-PROPENENITRILE, 2-METHYL- (9CI)

Known Uses:

HOMO- AND CO-POLYMERS, ELASTOMERS, COATINGS AND PLASTICS. CHEMICAL INTERMEDIATE. REPLACEMENT FOR ACRYLONITRILE IN CERTAIN USES. (NTP EXECUTIVE SUMMARY)

Short-Term Toxicity

• 2-WEEK (Gavage)  (C88050) Completed 
  • TOX-47 (NTIS No. PB2000-106-406)  (Toxicity Peer Review 11/08/1999)
    Toxicity Studies of Methacrylonitrile Administered by Gavage to F344/N Rats and B6C3F1Mice (CAS No. 126-98-7)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 0.3, 0.6, 1.2, 2.4, 4.8 G/L; M: 0, 0.15, 0.3, 0.6, 1.2, 2.4 G/L; 5/GRP
• 13-WEEK (Gavage)  (C88050) Report Complete 
  • TOX-47 (NTIS No. PB2000-106-406)  (Toxicity Peer Review 11/08/1999)
    Toxicity Studies of Methacrylonitrile Administered by Gavage to F344/N Rats and B6C3F1Mice (CAS No. 126-98-7)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,7.5,15.0,30.0,60.0,120.0 MG/KG/DAY; M: 0,0.75,1.5,3.0,6.0,12.0 MG/KG/DAY; RATS: 20/GRP; MICE: 10/GRP

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C88050B) Report Complete 
  • TR-497 (NTIS No. PB2002-102199)  (Peer Review 05/03/2001)
    Toxicology and Carcinogenesis Studies of Methacrylonitrile (CAS No. 126-98-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: RATS: 0, 3, 10, OR 30 MG/KG MICE: 0, 1.5, 3, OR 6 MG/KG; 50/SEX/DOSE/SPECIES

Special Studies

• Absorption Disposition Metabolism Elimination (Gavage)  (S0679) Completed 
  • Citation: GHANAYEM, B.I., SANCHEZ, I.M., BURKA, L.T., EFFECTS OF DOSE, STRAIN & DOSING VEHICLE ON METHACRYLONITRILE DISPOSITION IN RATS & IDENTIFICATION OF A NOVEL-EXHALED METABOLITE: DRUG METAB & DISP. VOL 20, #5, 643-652, 1992
  • M Rats: F344/N; M Rats: Sprague Dawley
  • Dose: 1.15, 11.5, 115 mg/kg
• Absorption Disposition Metabolism Elimination  (S0730) Completed 
  • Citation: BURKA, L.T., SANCHEZ, I.M., AMED, A.E., GHANAYEM, B.I., COMPARATIVE METABOLISM AND DISPOSITION OF ACRYLONITRILE AND METHACRYLONITRILE IN RATS, ARCH TOXICOL 68: 611-618, 1994
  • M Rats: F344/N
• Metabolism  (S0727) Completed 
  • Citation: GHANAYEM, B. I., & BURKA, L.T., EXCRETION AND IDENTIFICATION OF METHACRYLONITRILE METABOLITES IN THE BILE OF MALE F344 RATS DRUG METABOLISM AND DISPOSITION , VOL 24, #4, 390-394, 1996
  • M Rats: F344/N
• Other  (S0728) Completed 
  • Citation: DEMBY, K.B., WHITE, T.C., GHANAYEM, B.I., DETERMINATION OF METHACRYLONITRILE IN SERUM USING GAS CHROMATOGRAPHY AND FLAME IONIZATION DETECTION, JRNL OF CHROMATOGRAPHY, 579, 1992, 153-157
• Toxicokinetic Study  (S0729) Completed 
  • Citation: DEMBY, K.B., SANCHEZ, I.M., & GHANAYEM, B.I., SINGLE DOSE BLOOD TOXICOKINETCS OF METHACRYLONITRILE IN THE F344 RAT, TOXICOLOGY & APPLIED PHARMACOLOGY 119, 115-121 (1993)
  • M Rats: F344/N

Genetic Toxicology

• Drosophila  (042416) Completed 
  • Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Micronucleus  (A05400) Completed 
  • Rats: F344
  • Male Negative 
• Micronucleus  (A38969) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Micronucleus  (A63179) Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (799133) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Negative 
• Salmonella  (926215) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Negative 

Organ Systems Toxicity

• 16 WEEKS Continuous Breeding (Gavage)  (RACB94019) Completed 
  • NTIS No. PB97-176390
    Citation: Reproductive Toxicity of Methacrylonitrile (CAS # 125-98-7) Administered in Diet to Sprague-Dawley Rats
  • M/F Rats: Sprague Dawley
  • Dose: 0, 2, 7, OR 20 MG/KG
• Conventional Teratology (Gavage)  (TER92117) Completed 
  • NTIS No. PB93-190072
    Citation: Final Report on the Developmental Toxicity of Methacrylonitrile in Sprague-Dawley Rats
  • Rats: Sprague Dawley
  • Rats Maternal Negative 
  • Rats Fetal Negative 
  • Dose: 0, 5, 25, 50 MG/KG GD: 6-15
• GESTATIONAL DAYS 6 - 19 Conventional Teratology (Gavage)  (TER92122) Completed 
  • NTIS No. PB93-196061
    Citation: Final Report on the Developmental Toxicity of Methacrylonitrile in New Zealand White Rabbits
  • Rabbit: New Zealand White
  • Rabbits Maternal Negative 
  • Rabbits Fetal Negative 
  • Dose: 0, 1, 3, 5 MG/KG/DAY
• Teratology Pilot Studies (Gavage)  (TRP91020) Completed 
  • Rabbit: New Zealand White
  • Dose: 0, 5, 10, 25, 50, 75 MG/KG
• GD 6 THROUGH 15 Teratology Pilot Studies (Gavage)  (TRP91021) Completed 
  • F Rats: Sprague Dawley
  • Dose: 0, 10, 50, 75, 100, 125 MG/KG
• GD 6 THROUGH 19 Teratology Pilot Studies (Gavage)  (TRP92058) Completed 
  • F Rabbit: New Zealand White
  • Dose: 0 OR 7.5 MG/KG