National Toxicology Program

CASRN: 75-34-3

Formula: C2-H4-CL2

Synonyms/Common Names:

• ETHYLIDENE DICHLORIDE

Known Uses:

SOLVENT. CLEANING AGENT. FUMIGANT. CHEMICAL INTERMEDIATE. (TDB)

Short-Term Toxicity

• 14-Day (Gavage)  (C04535) Completed 
  • NTIS No. PB283345  (Peer Review 01/18/1978)
    Citation: Bioassay of 1,1-Dichloroethane for Possible Carcinogenicity (CAS No. 75-34-3)
  • Rats: Osborne Mendel; Mice: B6C3F1
• 13-Week (Gavage)  (C04535) Completed 
  • NTIS No. PB283345  (Peer Review 01/18/1978)
    Citation: Bioassay of 1,1-Dichloroethane for Possible Carcinogenicity (CAS No. 75-34-3)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: R: 0,562,5620, M: 0,1000,10000 MG/KG/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Gavage)  (C04535) Report Complete 
  • TR-066 (NTIS No. PB283345)  (Peer Review 01/18/1978)
    Bioassay of 1,1-Dichloroethane for Possible Carcinogenicity (CAS No. 75-34-3)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Equivocal 
  • Male Mice Negative 
  • Female Mice Equivocal 
  • Dose: MR: 0,382,764 (AVG), FR: 0,475,950 (AVG), MM: 0,1442,2885 (AVG), FM: 0,1665,3331 (AVG) MG/KG/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (508873) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Salmonella  (777132) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
  •  Negative