Testing Information

Testing Status of Agents at NTP

Sodium nitrite

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http://ntp.niehs.nih.gov/go/TS-C02084

CASRN: 7632-00-0

Formula: NA N O2

Synonyms/Common Names:

  • DIAZOTIZING SALTS
  • NITROUS ACID, SODIUM SALT

Known Uses:

CHEM. INTERM., PRESERVATIVE IN FOOD, MANUF. AZO DYES, VASODILATOR, ANTIDOTE FOR CYANIDE POISONING (MERCK 1989)

Short-Term Toxicity

  • 13-WEEK (Dosed-Water)  (C88007) Completed 
    • NTIS No. PB2001-107676
      Citation: Toxicology and Carcinogenesis Studies of Sodium Nitrite (CAS No. 7632-00-0) IN F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 375 - 5000 PPM/10 PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Dosed-Water)  (C88007B) Report Complete 
    • TR-495 (NTIS No. PB2001-107676)  (Peer Review 05/18/2000)
      Toxicology and Carcinogenesis Studies of Sodium Nitrite (CAS No. 7632-00-0) IN F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: R&M: 0, 0.075, 0.15, OR 0.3%; 50/SEX/DOSE

Special Studies

  • Toxicokinetic Study (Gavage; Intravenous)  (S0548) Completed 
    • Citation: TOXICOKINETICS OF SODIUM NITRITE IN RODENTS. AMENDED REPORT. 03/10/04. [AMENDED FINAL REPORT CHEM00474. 03/10/04. AMENDED REPORTS OF CHEM00475 (PART 3) AND CHEM00474 (PART 2) ARE INCLUDED IN THIS REPORT].
    • M/F Rats: F344/N; M/F Mice: B6C3F1; M/F Rats: F344/N; M/F Mice: B6C3F1
    • Dose: RATS (M & F) IV=20MG/KG, ORALLY=40 OR 80MG/KG MICE (M & F) IV=20MG/KG, ORALLY=62.5 OR 125MG/KG

Genetic Toxicology

  • Micronucleus  (A10342) Completed 
    • Rats: F344
    • Male Negative 
  • Micronucleus  (A17282) Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A52858) Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (359703) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 

Organ Systems Toxicity

  • Continuous Breeding (Dosed-Water)  (RACB88071) Completed 
    • NTIS No. PB91-132027
      Citation: Final Report on the Reproductive Toxicity of Sodium Nitrite in Swiss CD-1 Mice
    • M/F Mice: Swiss
    • Dose: 0,.06,.12,.24,.36,.48%; 0,.06,.12,.24%; N/A; 0,.24%

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Web page last updated on January 22, 2009