Testing Status of Agents at NTP
Isophosphamide
CASRN: 3778-73-2
Formula: C7-H15-CL2-N2-O2-P
Synonyms/Common Names:
- N,3-BIS(2-CHLOROETHYL)TETRAHYDRO-2H,1,3,2-OXAZAPHOSPHARIN-2-AMINE,2-OXIDE (9CI)
Known Uses:
ANTICANCER AGENT
Short-Term Toxicity
- 14-Day (Intraperitoneal Injection)
(C01638) Completed
- NTIS No. PB275677
(Peer Review 09/26/1977)
Citation: Bioassay of Isophosphamide for Possible Carcinogenicity (CAS No. 3778-73-2) - Rats: Sprague Dawley; Mice: B6C3F1
- NTIS No. PB275677
(Peer Review 09/26/1977)
- 13-Week (Intraperitoneal Injection)
(C01638) Completed
- NTIS No. PB275677
(Peer Review 09/26/1977)
Citation: Bioassay of Isophosphamide for Possible Carcinogenicity (CAS No. 3778-73-2) - Rats: Sprague Dawley; Mice: B6C3F1
- Dose: MR: 0,2.4,48, MM: 0,4,80 MG/KG/5 PER GROUP
- NTIS No. PB275677
(Peer Review 09/26/1977)
Long-Term Carcinogenicity
- 2-Year (Intraperitoneal Injection)
(C01638) Report Complete
- TR-032 (NTIS No. PB275677)
(Peer Review 09/26/1977)
Bioassay of Isophosphamide for Possible Carcinogenicity (CAS No. 3778-73-2) - Rats: Sprague Dawley; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Negative
- Female Rats Positive
- Male Mice Negative
- Female Mice Positive
- Dose: R: 0,6,12, M: 0,10,20 MG/KG/35 PER GROUP
- TR-032 (NTIS No. PB275677)
(Peer Review 09/26/1977)
Web page last updated on January 22, 2009