Testing Information

Testing Status of Agents at NTP

IPD (3,3'-iminobis-1-propanol dimethanesulfonate (ester) hydrochloride)

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http://ntp.niehs.nih.gov/go/TS-C01547

CASRN: 3458-22-8

Formula: C8-H19-N-O6-S2.CL-H

Known Uses:

ANTICANCER DRUG

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C01547) Completed 
    • NTIS No. PB277455  (Peer Review 11/28/1977)
      Citation: Bioassay of 3,3'-Iminobis-1-propanol Dimethanesulfonate (Ester) Hydrochloride (IPD) for Possible Carcinogenicity (CAS No. 3458-22-8)
    • Rats: Sprague Dawley; Mice: B6C3F1
  • 13-Week (Intraperitoneal Injection)  (C01547) Completed 
    • NTIS No. PB277455  (Peer Review 11/28/1977)
      Citation: Bioassay of 3,3'-Iminobis-1-propanol Dimethanesulfonate (Ester) Hydrochloride (IPD) for Possible Carcinogenicity (CAS No. 3458-22-8)
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Dose: R: 0,24,192, M: 0,40,320 MG/KG/5 PER GROUP

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C01547) Report Complete 
    • TR-018 (NTIS No. PB277455)  (Peer Review 11/28/1977)
      Bioassay of 3,3'-Iminobis-1-propanol Dimethanesulfonate (Ester) Hydrochloride (IPD) for Possible Carcinogenicity (CAS No. 3458-22-8)
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Equivocal 
      • Male Mice Equivocal 
      • Female Mice Equivocal 
    • Dose: R: 0,12,24,48, M: 0,20,40 MG/KG/35 PER GROUP

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Web page last updated on January 22, 2009