Testing Status of Agents at NTP
alpha-Methylstyrene
CASRN: 98-83-9
Formula: C9-H10
Synonyms/Common Names:
- BENZENE, (1-METHYLETHENYL)- (9CI)
- ISOPROPENYLBENZENE
Known Uses:
MONOMER FOR POLY(ALPHA-METHYLSTYRENE). (TDB)
Nomination Background
Short-Term Toxicity
- 2-WEEK (Inhalation)
(C88006) Completed
- Rats: F344/N; Mice: B6C3F1
- 13-WEEK (Inhalation)
(C88006B) Completed
- (Peer Review 06/12/2006) Citation: Toxicology and Carcinogenesis Studiies of ?-Methylstyrene (CAS No. 98-83-9) in F344/N Rats and B6C3F1 Mice (inhalation studies)
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 75, 150, 300, 600 OR 1000 PPM; R: 20/SEX M: 10/SEX
Long-Term Carcinogenicity
- 2-YEAR (Inhalation)
(C88006B) Report Review
- TR-543
(Peer Review 06/12/2006)
Toxicology and Carcinogenesis Studiies of ?-Methylstyrene (CAS No. 98-83-9) in F344/N Rats and B6C3F1 Mice (inhalation studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Some Evidence
- Female Rats No Evidence
- Male Mice Equivocal Evidence
- Female Mice Clear Evidence
- Dose: R: 0, 100, 300, OR 1000 PPM M: 0, 100, 300, OR 600 PPM; 50/SEX/SPECIES
- TR-543
(Peer Review 06/12/2006)
Special Studies
- Absorption Disposition Metabolism Elimination (Intravenous; Gavage; Inhalation)
(S0632) Completed
- M Rats: F344/N; M Rats: F344/N; M Rats: F344/N
- Dose: iv: 10 mg/kg gavage: 1000 mg/kg inhalation: 300 and 900 ppm
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(235924) Completed
- Chromosome Aberation Negative
- Sister Chromatid Exchange Positive
- Micronucleus
(A36497) Completed
- Mice: B6C3F1
- Male Negative
- Female Positive
- Salmonella
(338665) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
- Negative
Web page last updated on January 22, 2009