National Toxicology Program

CASRN: 91-17-8

Related: TETRALIN (CAS: 119-64-2)

Formula: C10-H18

Synonyms/Common Names:

• NAPHTHALENE, DECAHYDRO- (9CI)

Known Uses:

RESEARCH CHEMICAL, SOLVENT FOR NAPHTHALENE, FATS, RESINS, OILS, IN MOTOR FUEL & LUBRICANTS.

Nomination Background

Short-Term Toxicity

• 2-WEEK (Inhalation)  (C93026) Completed 
  • NTIS No. PB2005-107379  (Peer Review 09/05/2002)
    Citation: Toxicology and Carcinogenesis Studies of Decalin (CAS No. 91-17-8) in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Decalin in Male NBR Rats (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1; Rats: NCI Black Reiter (NBR)
  • Dose: R&M: 0, 25, 50, 100, 200, OR 400 PPM; 5/SEX/SPECIES/GROUP
• 13-WEEK (Inhalation)  (C93026) Completed 
  • NTIS No. PB2005-107379  (Peer Review 09/05/2002)
    Citation: Toxicology and Carcinogenesis Studies of Decalin (CAS No. 91-17-8) in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Decalin in Male NBR Rats (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 25, 50, 100, 200, OR 400 PPM R: 20/SEX/GROUP M: 10/SEX/GROUP MR: 5/GROUP RENAL TOX

Long-Term Carcinogenicity

• 2-YEAR (Inhalation)  (C93026) Report Complete 
  • TR-513 (NTIS No. PB2005-107379)  (Peer Review 09/05/2002)
    Toxicology and Carcinogenesis Studies of Decalin (CAS No. 91-17-8) in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Decalin in Male NBR Rats (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Clear Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice Equivocal Evidence 
  • Dose: M&F MICE AND FEMALE RATS: 0, 25, 100, OR 400 PPM MALE RATS: 0, 25, 50, 100, OR 400 PPM (20 MALES); 50/SEX/SPECIES/GROUP

Genetic Toxicology

• Micronucleus  (A40482) Completed 
  • Mice: B6C3F1
  • Male Weakly Positive 
  • Female Negative 
• Salmonella  (A08124) Completed 
  •  Negative 

Organ Systems Toxicity

• GD 7-14 Short-Term in vivo Repro. Tox. (Gavage)  (T0037) Completed 
  • NTIS No. PB83-257600
    Citation: Screening of Priority Chemicals for Reproductive Hazards
  • F Mice: Swiss
  • Dose: 2700 MG/KG BODY WEIGHT